CAS: 1074-89-1; 6-Methoxy-9H-Purine

相似化合物

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CAS号124-41-4 甲醇钠 | CAS号87-42-3 6-氯嘌呤 | CAS号19765-64-1 6-methoxypurine... | CAS号555-16-8 对硝基苯甲醛 | CAS号65-85-0 苯甲酸 | CAS号85110-40-3 9-(1-ethoxyethy... | CAS号37109-88-9 2′-Deoxy-6-O-me... | CAS号5746-29-2 Inosine, 6-O-methyl | CAS号21802-76-6 7-benzyl-6-meth... | CAS号6937-62-8 9-benzyl-6-meth... | CAS号578-76-7 7-甲基鸟嘌呤 | CAS号5746-29-2 Inosine, 6-O-methyl | CAS号38917-24-7 6-methoxy-7-met... | CAS号3324-66-1 6-methoxy-3-met...

9-<2-Deoxy-β-D-Erythro-Pentofuranosyl>-6-Methoxy-9H-Purine 以 盐酸,水 用作溶剂,化学反应生成6-甲氧基嘌呤
参考文献:6-取代的9-(2-脱氧-β-D-异戊-呋喃呋喃糖基)嘌呤及其9-(1-烷氧乙基)对应部分的酸性水解:动力学和机理.1个
标题:6-取代的9-(2-脱氧-β-D-异戊-呋喃呋喃糖基)嘌呤及其9-(1-烷氧乙基)对应部分的酸性水解:动力学和机理.1个
摘要:已经在不同浓度的氧离子下测量了几种6-取代的9-(2-脱氧-β-D-赤-戊呋喃糖基)嘌呤和9-(1-烷氧基乙基)嘌呤的水解速率常数.解释了改变烷氧基极性性质对未取代的9-(1-烷氧基乙基)嘌呤水解的影响,这表明该反应通过质子化碱部分的限速离去并伴随形成一个烷氧基乙基氧碳鎓离子.通过比较6-取代基对这些化合物及其9-(1-烷氧基乙基)反应剂的反应性的影响,将相同的机理应用于9-(2-脱氧-β-D-赤-戊呋喃糖基)嘌呤的水解.-部分.当2'-脱氧腺苷水解后进行1 H NMR光谱.
Doi:10.1016/s0040-4020(01)90052-3

专利信息

专利号:US-6818633-B2
优先权日:2001-06-29
标题:Antiviral compounds and methods for synthesis and therapy
发明人：BALZARINI JAN M R; DE CLERCQ ERIK D A; HOLY ANTONIN
权利人:ACAD OF SCIENCE CZECH REPUBLIC; REGA STICHTING
摘要:Novel compounds are provided having formula (I)whereR1, R2, R3, R4, Z, X and * are defined herein. Also provided are antiviral methods for use and processes for synthesis of the compounds of formula (I).

专利号:US-4849513-A
优先权日:1983-12-20
标 题 :Deoxyribonucleoside phosphoramidites in which an aliphatic amino group is attached to the sugar ring and their use for the preparation of oligonucleotides containing aliphatic amino groups
发明人：SMITH LLOYD M; FUNG STEVEN; KAISER ROBERT J
权利人:CALIFORNIA INST OF TECHN
摘要:The invention consists of compounds and methods for the synthesis of oligonucleotides which contain one or more free aliphatic amino groups attached to the sugar moieties of the nucleoside subunits. The synthetic method is versatile and general, permitting amino groups to be selectively placed at any position on oligonucleotides of any composition or length which is attainable by current DNA synthetic methods. Fluorescent dyes or other detectable moieties may be covalently attached to the amino groups to yield the corresponding modified oligonucleotide.

专利号:US-5118802-A
优先权日:1983-12-20
标 题:DNA-reporter conjugates linked via the 2' or 5'-primary amino group of the 5'-terminal nucleoside
发明人：SMITH LLOYD M; FUNG STEVEN; KAISER JR ROBERT J
权利人:CALIFORNIA INST OF TECHN
摘要:The invention consists of compounds and methods for the synthesis of oligonucleotides which contain one or more free aliphatic amino groups attached to the sugar moieties of the nucleoside subunits. The synthetic method is versatile and general, permitting amino groups to be selectively placed at any position on oligonucleotides of any composition or length which is attainable by current DNA synthetic methods. Fluorescent dyes or other detectable moieties may be covalently attached to the amino groups to yield the corresponding modified oligonucleotide.

专利号:US-2012149888-A1
优先权日:2009-02-22
标 题:Synthesis of ara-2'-o-methyl-nucleosides, corresponding phosphoramidites and oligonucleotides incorporating novel modifications for biological application in therapeuctics, diagnostics, g- tetrad forming oligonucleotides and aptamers
发明人：SRIVASTAVA SURESH C; PANDEY DIVYA; SRIVASTAVA NAVEEN P; SRIVASTAVA ALOK
权利人:SRIVASTAVA SURESH C; PANDEY DIVYA; SRIVASTAVA NAVEEN P; SRIVASTAVA ALOK
摘要:The present invention relates to synthesis, purification and methods to obtain high purity novel 2′-arabino-O-methyl nucleosides and the corresponding phosphoramidites of various arabinonucleoside bases and introduction of such units into defined sequence synthetic DNA and RNA. Various synthetic oligonucleotides, such as HIV integrase inhibitor 14-mer and thrombin binding oligonucleotide, thrombin-1, bearing ara-2′-omethyl modification have been synthesized. It is anticipated the oligonucleotides incorporating these monomers will exhibit biological activities related to antisense approach approach, design of better SiRNA's, diagnostic agents. Similarly, it is anticipated that oligonucleotides incorporating such novel nucleosides will be useful to develop therapeutic candidates designing stable G-quadruplexes and Aptamers for oligonucleotide structure, folding topology, evaluation of biochemical properties and design and develop as therapeutic agents. It is further anticipated that the nucleosides, phosphates and triphosphates of this invention could develop as therapeutic agents.

专利号:US-5118800-A
优先权日:1983-12-20
标 题 :Oligonucleotides possessing a primary amino group in the terminal nucleotide
发明人：SMITH LLOYD M; FUNG STEVEN; KAISER JR ROBERT J
权利人:CALIFORNIA INST OF TECHN
摘要:The invention consists of compounds and methods for the synthesis of oligonucleotides which contain one or more free aliphatic amino groups attached to the sugar moieties of the nucleoside subunits. The synthetic method is versatile and general, permitting amino groups to be selectively placed at any position on oligonucleotides of any composition or length which is attainable by current DNA synthetic methods. Fluorescent dyes or other detectable moieties may be covalently attached to the amino groups to yield the corresponding modified oligonucleotide.

专利号:US-7115592-B2
优先权日:2003-06-16
标题:Phosphonate substituted pyrimidine compounds and methods for therapy
发明人：BALZARINI JAN M R; DE CLERCQ ERIK D A; HOLY ANTONIN; HOCKOVA DANA
权利人:BIOCHEMISTRY OF THE ACADEMY OF
摘要:Novel compounds are provided having formula (I) n nwheren n R 1 , R 2 , R 3 , R 4 , Z, X and * are defined herein. Also provided are antiviral methods for use and processes for synthesis of the compounds of formula (I).