CAS: 125-20-2; 3,3-Bis(4-Hydroxy-5-Isopropyl-2-Methylphenyl)Isobenzofuran-1(3H)-One

相似化合物

125-20-2 596-27-0 77-09-8

上下游产品

phthalic anhydride thymol3,3-bis-(4-acetoxy-5-isopropyl-2-methyl-phenyl)-phthalide

苯酐,百里酚置于niobium Pentachloride体系中,用 甲烷磺酸 用作溶剂,化学反应 1.33H,以70%的收率获得百里酚酞
参考文献:Nbcl 5促进酞菁衍生物的高效合成:光学表征和溶剂变色效应
标题:Nbcl 5促进酞菁衍生物的高效合成:光学表征和溶剂变色效应
摘要:衍生自酞菁的有机染料具有广泛的工业用途,可以使用路易斯酸通过friedel-Crafts酰化反应,然后将其与羰基化合物进行加成反应来合成.这项工作旨在调查nbcl 5的使用作为酰化反应的催化剂.研究了酞菁衍生物在几种溶剂中以及在不同ph条件下的行为.这些化合物根据ph和溶剂表现出变色效果,使其可用作指示剂.酞酸酯根据介质的状态改变其构象.这些化合物的光物理研究是通过它们的uv-Vis吸收光谱进行的.在这里,我们显示了取决于溶剂和介质ph值的酞菁衍生物的伞状构象变化.
Doi:10.1002/jhet.3664

专利信息

专利号:US-4041111-A
优先权日:1975-03-04
标题:Phosphonate monoesters and method of preparation
发明人：KELLY SUSAN J; BUTLER LARRY G
权利人:PURDUE RESEARCH FOUNDATION
摘要:Synthesis of phosphonate monoesters, as well as the use of such monoesters as substrates for enzymes which normally hydrolyze phosphodiester linkages, and a method for distinguishing between Type I and Type II phosphodiesterase enzymes using such monoesters as substrates are disclosed herein. Monoesters of phosphonic acids are prepared by the displacement of chloride from an appropriate phosphonic acid dichloride by a phenol or alcohol with pyridine as the solvent, reacting the same and then removing the solvent, after which the remaining ester chloride and dichloride are hydrolyzed by addition of water. The acid and ester are then separated and the acid-free ester is taken up in a polar organic solvent and precipitated as a salt by the addition of aqueous base, with the product then being filtered, washed with fresh acetone, dried and then stored until needed. The thus formed phosphonate monoesters are shown to be effective for use as substrate for phosphodiesterase of the Type I specificity and are shown to be ineffective for use as substrates for phosphodiesterase of the Type II specificity. The type of phosphodiesterase is therefore determined by the amount of activity against phosphonate monoesters.

专利号:US-3795666-A
优先权日:1969-08-01
标 题 :Method of synthesizing peptides in the presence of a carbodiimide and of 3-hydroxy-4-oxo-3,4-dihydro-1,2,3-benzotriazine
发明人：KONIG W; GEIGER R; WOLF E
权利人:HOECHST AG
摘要:IMPROVED SYNTHESIS OF PEPTIDES BY THE CARBODIIMIDE METHOD IN WHICH AN AMINO-PROTECTED AMINO ACID OR PEPTIDE HAVING A REACTIVE CARBOXY GROUP IS CONDENSED WITH A CARBOXY-PROTECTED AMINO ACID OR PEPTIDE HAVING A REACTIVE AMINO IN THE PRESENCE OF 3-HYDROXY-4-OXO3,4-DIHYDRO-1,2,3-BENZOTRIAZINE AS WELL AS IN THE PRESENCE OF A CARBODIIMIDE SUCH AS DICYCLOHEXYL CARBODIIMIDE.

专利号:US-3772339-A
优先权日:1971-10-26
标题 :Preparation of naphthalides
发明人：GREENWALD R
权利人:POLAROID CORP
摘要:THIS INVENTION RELATES TO THE SYNTHESIS OF CARBOXYSUBSTITUTED NAPHTHOL NAPHTHALIDE INDICATOR DYES BY REACTING A 3-(3''CARBOALKOXY-4''-HYDROXY NAPHTHYL)NAPHTHALIDE INTERMEDIATE AND A 1-NAPHTHOL IN THE PRESENCE OF A LEWIS ACID CATALYST AND CONVERTING THE 3''-CARBOALKOXY TO A 3''-CARBOXY GROUP TO YIELD THE DYE PRODUCT.

专利号:US-9976179-B2
优先权日:2011-03-30
标 题 :Nucleic acid sequencing technique using a pH-sensing agent
发明人：HAUSHALTER ROBERT C
权利人:PARALLEL SYNTHESIS TECH; PARALLEL SYNTHESIS TECH INC
摘要:The invention relates to a composition, method and apparatus for determining the sequence of a nucleic acid strand utilizing a pH-sensing agent.

专利号:US-2012149919-A1
优先权日:2009-08-26
标题 :Maleic anhydride synthesis catalyst precursor and process for its preparation
发明人：ALTWASSER STEFAN; DOBNER CORNELIA KATHARINA; WILMER HAGEN; ROSOWSKI FRANK
权利人:ALTWASSER STEFAN; DOBNER CORNELIA KATHARINA; WILMER HAGEN; ROSOWSKI FRANK; BASF SE
摘要:A process for preparing a vanadium, phosphorus, and oxygen comprising catalyst precursor for preparing maleic anhydride by heterogeneously catalyzed gas-phase oxidation of a hydrocarbon having at least four carbon atoms, which comprisesn (a) reacting vanadium pentoxide with 102% to 110% strength phosphoric acid in the presence of isobutanol and optionally of a primary or secondary, noncyclic or cyclic, unbranched or branched, saturated alcohol having 3 to 6 carbon atoms in a temperature range from 80 to 160° C.; (b) isolating the precipitate formed; (c) (i) drying the isolated precipitate down to a residual isobutanol content of less than 5% by weight;n (ii) then passing a gas which in addition to one or more inert gases comprises 0.1% to 9% by volume of oxygen through the dried precipitate, directly or after isolation, in the temperature range from 130° C. to 200° C.

专利号:US-6667161-B1
优先权日:1997-10-27
标 题 :Chromogenic substrates of sialidase of bacterial, viral, protozoa, and vertebrate origin and methods of making and using the same
发明人：JOHNSON STEPHEN C; LOU MING; YAN SHIJIA
权利人:IBBEX INC; UAB RESEARCH FOUNDATION
摘要:The current invention relates to the design, synthesis, and biochemical evaluation of chromogenic substrate compounds for sialidases of bacterial, viral, protozoa, and vertebrate (including human) origin. In particular, this invention provides a novel class of effective compounds as chromogenic substrates of these sialidases which yield chromogenic products after reactions catalyzed by sialidase take place. Also provided are methods of making these substrate compounds, methods of diagnosis and prognosis of sialidase related diseases using these substrate compounds.