CAS: 2444-46-4; N-(4-Hydroxy-3-Methoxybenzyl)Nonanamide

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CAS号764-85-2 壬酰氯 | CAS号1196-92-5 4-(氨基甲基)-2-甲氧基苯酚 | CAS号7149-10-2 香兰素胺盐酸盐 | CAS号112-05-0 正壬酸 | CAS号1120-07-6 壬醯胺 | CAS号4421-08-3 4-羟基-3-甲氧基苯甲腈 | CAS号90-05-1 愈创木酚 | CAS号102811-97-2 N-(4-benzyloxy-... | CAS号2426-87-1 4-苄氧基-3-甲氧基苯甲醛 | CAS号146690-24-6 sodium,2-[2-met... | CAS号143827-59-2 N-[[4-(2-hydrox... | CAS号1196-92-5 4-(氨基甲基)-2-甲氧基苯酚 | CAS号1731-84-6 壬酸甲酯

壬酸置于氯化亚砜,碳酸氢钠体系中,用 氯仿,水 用作溶剂,化学反应 5.75H,反应生成香草壬酰胺
参考文献:一锅中异质金属,有机催化和酶联级联反应从木质素衍生化合物完全合成辣椒素类似物
标题:一锅中异质金属,有机催化和酶联级联反应从木质素衍生化合物完全合成辣椒素类似物
摘要:从可以衍生自木质素的化合物开始,在一锅中进行辣椒素类似物的总合成.异质钯纳米颗粒用于将醇氧化为醛,然后通过包括胺转氨酶的酶级联系统将其进一步转化为胺.结果表明,钯催化剂和酶级联体系可以在同一罐中成功地结合使用,无需任何中间体纯化即可将醇类转化为胺类.用酶级联系统制备的中间体香草醛胺可以进一步转化为辣椒素类似物,而无需使用脂肪酸和脂肪酶或在schotten-Baumann条件下在同一罐中进行任何纯化.醛醇化合物(简单的木质素模型)也可以用作合成辣椒素类似物的原料.使用左旋丙氨酸作为有机催化剂,香兰素可通过逆向醛醇缩合反应获得.可以将其与酶级联系统结合使用,以一步一步反应将醛醇化合物转化为香草醛.
Doi:10.1002/adsc.201301148

专利信息

专利号:US-10308588-B2
优先权日:2014-12-15
标 题 :Synthesis of amides and amines from aldehydes or ketones by heterogeneous metal catalysis
发明人：CÓRDOVA ARMANDO; PALO-NIETO CARLOS; AFEWERKI SAMSON
权利人:ORGANOFUEL SWEDEN AB
摘要:A mild and efficient synthesis of primary amines and amides from aldehydes or ketones using a heterogeneous metal catalyst and amine donor is disclosed. The initial heterogeneous metal-catalyzed reaction between the carbonyl and the amine donor components is followed by the addition of a suitable acylating agent component in one-pot, thus providing a catalytic one-pot three-component synthesis of amides. Integration of enzyme catalysis allows for eco-friendly one-pot co-catalytic synthesis of amides from aldehyde and ketone substrates, respectively. The process can be applied to asymmetric synthesis or to the co-catalytic one-pot three-component synthesis of capsaicin and its analogues from vanillin or vanillyl alcohol. A co-catalytic reductive amination/dynamic kinetic resolution (dkr) relay sequence for the asymmetric synthesis of optically active amides from ketones is disclosed. Implementation of a catalytic reductive amination/kinetic resolution (kr) relay sequence produces the corresponding optically active amide product and optical active primary amine product with the opposite stereochemistry from the starting ketones.

专利号:US-11168050-B2
优先权日:2014-03-27
标 题 :Efficient synthesis of amines and amides from alcohols and aldehydes by using cascade catalysis
发明人：CÓRDOVA ARMANDO; BERGLUND PER; ANDERSON MATTIAS; AFEWERKI SAMSON
权利人:XP CHEMISTRIES AB
摘要:The present invention relates generally to an eco-friendly methodology for the conversion of alcohols and aldehydes to amines and amides using an integrated enzyme cascade system with metal- and organocatalysis. More specifically, the present invention relates to synthesis of capsaicinoids starting from vanillin alcohol and using a combination of an enzyme cascade system and catalysts. Furthermore, the method also relates to synthesis of capsaicinoids derivatives starting from vanillin alcohol derivatives and using a combination of an enzyme cascade system and catalysts.

专利号:US-2024229089-A1
优先权日:2021-04-30
标 题 :A process for enzymatic synthesis of amides from amines and carboxylic acids or esters
发明人：LIN SHUANGZHENG; CORDOVA ARMANDO; DEIANA LUCA; IBRAHEM ISMAIL
权利人:XP CHEMISTRIES AB
摘要:The present invention relates to A process for enzymatic synthesis of amides of formula (III) from amines of formula (I) and compounds of formula (II). characterized in that the lipase is immobilized on a rotary bed reactor or on a spin-fixed-bed reactor and a Dean-Stark apparatus is used for dehydration.

专利号:US-12188057-B2
优先权日:2017-10-20
标 题 :Primer-independent DNA polymerases and their use for DNA synthesis
发明人：SALAS FALGUERAS MARGARITA; REDREJO RODRIGUEZ MODESTO; KRUPOVIC MART; FORTERRE PATRICK
权利人:CONSEJO SUPERIOR INVESTIGACION; PASTEUR INSTITUT
摘要:The present invention provides an isolated peptide of SEQ ID NO: 1 needed for primase active as well as new replicative DNA polymerase enzymes, preferably that of SEQ ID NO: 2, comprising said peptide. Thus, these DNA polymerases are endowed with priming activity and do not require externally provided primers for initiating and performing DNA amplification. These polymerases are able to carry out a faithful and processive de novo DNA synthesis of DNA templates in the absence of pre-synthetized primers. Therefore, these enzymes of the invention act both as primases and DNA polymerases. Furthermore, they show translesion synthesis capacity, so that they may be useful not only for whole-genome amplification but also for the amplification of damaged DNAs. The invention further refers to methods for amplifying templates DNAs using these enzymes.

专利号:US-5094782-A
优先权日:1990-12-24
标 题:Synthesis of capsacin derivatives and their use as an analgesic drug and vessel dilation drug
发明人：CHEN ING-JUN; YEH JWU-LAI
权利人:NAT SCIENCE COUNCIL REPUBLIC CHINA
摘要:Nonanoyl vanillylamide succinate was synthesized from synthetic capsaicin (nonanoyl vanillylamide) and succinic anhydride. The antinociceptive and cardiovascular effects of nonanoyl vanillylamide and its derivatives were investigated. We found that nonanoyl vanillylamide and nonanoyl vanillylamide succinate strongly inhibited the writhing response, led to the vascular smooth muscle relaxation, produces bradycardia and a fall of blood pressure. The potency of nonanoyl vanillylamide succinate was found to be slight greater than that of nonanoyl vanillylamide, when compared with the same molar dose/kg of their administrations.

专利号:US-12325864-B2
优先权日:2021-05-06
标题:Recombinant virus vector (RVV) for inhibiting epidermal growth factor receptor (EGFR) activity and method of making an agent/target cell complex to increase cetuximab-like protein (CLP) production
发明人：THOMPSON BRADLEY G
权利人:KINASE PHARMA INC
摘要:The present disclosure relates to one or more agents, therapies, treatments, and methods of use of the agents and/or therapies and/or treatments for increasing production of a Cetuximab-like protein (CLP) by a subject that is administered the agent, therapy or treatment. Embodiments of the present disclosure can be used as a therapy or a treatment for a subject that has a condition that may benefit from reducing the DNA synthesis of genes that regulate cellular growth and proliferation.