CAS: 40957-83-3; 7-Hydroxy-3-(4-Hydroxyphenyl)-6-Methoxy-4H-Chromen-4-One

该化合物是一种富稀类植物衍生的化合物,具有抗氧化性特性,在调节细胞活动方面具有潜力,并可能有助于增强皮肤健康,减少氧化性压力和稳定细胞膜完整性. 研究表明,它在化妆品配方中的应用可以产生有利于产品效率和消费者福祉的有利结果.

结构式图片

上下游产品

4’,6,7-三羟异黄酮 6,7,4'-Trihydroxyisoflavone 17817-31-1
大豆甙元 Daidzein 486-66-8
染料木素 5,7-Dihydroxy-3-(4-Hydroxy-Phenyl)-Chromen-4-On 446-72-0
大豆异黄酮 Isoflavone 574-12-9
Glycitein 4'-O-β-D-Glucoside 1237605-01-4
黄豆黄苷 Glycitin 40246-10-4

合成工艺路线路线简述

  • 合成目标产物 Glycitein 主要起始原料 Isovanillin
  • (文献来源)合成步骤主要原料 Isovanillin
3,3-二甲氧基-1-[5-甲氧基-1,4-二(苯基甲氧基)苯基]-2-[4-(苯基甲氧基)苯基]-1-丙酮置于palladium On Activated Charcoal 盐酸,氢气体系中,用 甲醇,丙酮 作为反应溶剂,化学反应 0.25H,反应生成 黄豆黄素
参考文献:Nogradi,Mihaly; Szoellosy,Aron,Liebigs Annalen,1996,# 10,P. 1651-1652
标题:Nogradi,Mihaly; Szoellosy,Aron,Liebigs Annalen,1996,# 10,P. 1651-1652

海关参考信息

专利信息


专利号:US-7598291-B2
优先权日:2004-09-02
标题 :Methods and compositions for enhancing collagen and proteoglycan synthesis in the skin
发明人:NIMNI MARCEL; HAN BO
权利人:NIMNI MARCEL; HAN BO
摘要:A composition for application to the skin can stimulate the in vivo synthesis of collagen and proteoglycans and improve the appearance of the skin, increasing its elasticity and fullness. In general, a composition according to the present invention comprises: (1) an antioxidant compound in a quantity sufficient to enhance collagen synthesis in the skin; (2) an organic penetrant in which the antioxidant compound is soluble in a sufficient quantity that a concentration of the antioxidant compound sufficient to enhance collagen synthesis can be applied topically and penetrate the skin; (3) a mixture of essential amino acids; (4) a supplemental source of sulfur; and (5) a topical pharmaceutically acceptable carrier. The antioxidant compound can be lipoic acid, a lipoic acid analogue or derivative, a bioflavonoid, a constituent of ginkgo, or an isoflavone. The organic penetrant is preferably benzyl alcohol. Other ingredients, such as esters of tocopherol and ascorbic acid, can be included.

专利号:US-2010160244-A1
优先权日:2004-09-02
标 题 :Methods and compositions for enhancing collagen, proteoglycan, and glutathione synthesis in the skin
发明人:NIMNI MARCEL; HAN BO
权利人:NIMNI MARCEL; HAN BO
摘要:A composition for application to the skin can stimulate the in vivo synthesis of collagen and proteoglycans and improve the appearance of the skin, increasing its elasticity and fullness. In general, a composition according to the present invention comprises: (1) an antioxidant compound in a quantity sufficient to enhance collagen synthesis in the skin; (2) an organic penetrant in which the antioxidant compound is soluble in a sufficient quantity that a concentration of the antioxidant compound sufficient to enhance collagen synthesis can be applied topically and penetrate the skin; (3) a mixture of essential amino acids or hydrolyzed whey protein; (4) a supplemental source of sulfur; and (5) a topical pharmaceutically acceptable carrier. The antioxidant compound can be lipoic acid or a lipoic acid analogue or derivative. The organic penetrant is preferably benzyl alcohol. Other ingredients, such as esters of tocopherol and ascorbic acid, can be included.

专利号:US-2009062555-A1
优先权日:2007-08-28
标 题 :Synthesis of Isoflavone
发明人:HARMS ARTHUR E
权利人:HARMS ARTHUR E
摘要:The invention provides a process of manufacturing an isoflavone of the general formula 7 n n n n n n n n n n wherein R 1 , R 2 , R 3 , and R 4 each independently are H, OH, or an alkoxy, provided at least one of R 1 , R 2 , R 3 , and R 4 being OH, and one being alkoxy, or at least 2 groups being OH, comprising providing ketone (3) n n n n n n n n n n wherein R 1 , R 2 , R 3 , and R 4 are as stated above, combining (3) with trialkylortho formate, and a Lewis or Bronsted acid to produce the isoflavone, precipitating the isoflavone.

专利号:US-6849701-B2
优先权日:2001-03-02
标 题:Droplet polymerization method for synthesis of molecularly imprinted polymers
发明人:NORTON TUCKER
权利人:DU PONT
摘要:A droplet polymerization process is provided to create efficacious molecularly imprinted polymers (MIPs). Such imprinted polymers have increased surface area for adsorptive or catalytic reactions. This method provides for monomer-template interactions in the absence of a suspending medium, thereby permitting formation of MIPs with increased template selectivity and substantial processing advantages. The process is particularly useful for separating isoflavones from soy whey.

专利号:US-2014357576-A1
优先权日:2013-05-31
标题:Methods for enhancement of muscle protein synthesis
发明人:BREUILLE DENIS; STELLINGWERFF TRENT; MOORE DANIEL RYAN; OFFORD CAVIN ELIZABETH ANN; PHILLIPS STUART MARTIN
权利人:NESTEC SA
摘要:The present disclosure provides methods for enhancing muscle protein synthesis in an individual in need of same. Specifically, the present disclosure provides methods for enhancing muscle protein synthesis by enhancing myofibrillar muscle protein synthesis. The method includes administering to the individual a mixed macronutrient composition having (i) an amount of whey protein that is not capable of enhancing myofibrillar protein synthesis when ingested by itself and (ii) free leucine. The composition comprises at least about 5.0 g total leucine per dose.

专利号:WO-2015040533-A1
优先权日:2013-09-19
标题:Methods for enhancing muscle protein synthesis during energy deficit
发明人:BAILEY DAVID MARK; ZALTAS ERIC SCOTT; STELLINGWERFF TRENT; MOORE DANIEL RYAN; HAWLEY JOHN ALAN; BURKE LOUISE MARY
权利人:PREMIER NUTRITION CORP
摘要:The present disclosure provides methods for enhancing muscle protein synthesis in an individual in need of same. Specifically, the present disclosure provides methods for enhancing muscle protein synthesis during periods of negative energy balance, or energy deficit. The methods include administering to an individual suffering from energy deficit a composition comprising protein in an amount from about 15 g to about 30 g during a time period selected from the group consisting of during exercise, post-exercise, and combinations thereof. The methods also include administering to an individual suffering from energy deficit a composition comprising protein during a time period selected from the group consisting of during exercise, post-exercise, and combinations thereof, wherein the protein is administered in a dose that is higher than doses typically recommended for individuals experiencing energy balance.
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✅ COA系统入驻 | 共享模式

主要参考文献


1: Zhang B, Su JP, Bai Y, Li J, Liu YH. Inhibitory effects of O-methylated isoflavone glycitein on human breast cancer SKBR-3 cells. Int J Clin Exp Pathol. 2015 Jul 1;8(7):7809-17. eCollection 2015.
2: Hu YJ, Gao KG, Zheng CT, Wu ZJ, Yang XF, Wang L, Ma XY, Zhou AG, Jiang ZJ. Effect of dietary supplementation with glycitein during late pregnancy and lactation on antioxidative indices and performance of primiparous sows. J Anim Sci. 2015 May;93(5):2246-54. doi: 10.2527/jas.2014-7767. Erratum in: J Anim Sci. 2015 Jun;93(6):3226. doi: 10.1007/s11033-013-2526-2. Epub 2013 May 22. doi: 10.1016/j.foodchem.2012.03.135. Epub 2012 May 22. doi: 10.3390/biom4041093.
6: Winzer M, Rauner M, Pietschmann P. Glycitein decreases the generation of murine osteoclasts and increases apoptosis. Wien Med Wochenschr. 2010 Sep;160(17-18):446-51. doi: 10.1007/s10354-010-0811-4. Epub 2010 Aug 16. doi: 10.3390/molecules15085153. doi: 10.1016/j.cbi.2010.02.037. Epub 2010 Feb 25.

合成参考文献


参考文献:10.1371/journal.pone.0021781
摘要:Kim Y, Hollenbaugh JA, Kim D, Kim B. Novel PI3K/Akt Inhibitors Screened by the Cytoprotective Function of Human Immunodeficiency Virus Type 1 Tat. PLoS ONE. 2011 Jul 12;6(7):e21781. doi: 10.1371/journal.pone.0021781.
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