4-氟-3-甲基苯胺 反应生成 5-氯-2-氟甲苯 参考文献:Varma; Raman; Nilkantiah,Journal Of The Indian Chemical Society,1944,Vol. 21,P. 112,114 标题:Varma; Raman; Nilkantiah,Journal Of The Indian Chemical Society,1944,Vol. 21,P. 112,114
专利号:US-9771356-B2 优先权日:2012-09-21 标题 :Inhibitors of beta-hydroxylase for treatment of cancer 发明人:WANDS JACK R; DE LA MONTE SUZANNE; AIHARA ARIHIRO; OLSEN MARK JON; THOMAS JOHN-MICHAEL 权利人:RHODE ISLAND HOSPITAL; UNIV MIDWESTERN 摘要:The present invention relates to compounds which modulate (e.g., inhibit) the activity of beta-hydroxylase (e.g., Asparatyl (asparaginyl) β-hydroxylase (ASPH)), including novel 2-aryl-5-amino-3(2H)-furanone and 2-heteroaryl-5-amino-3(2H)-furanone compounds, pharmaceutical compositions thereof, methods for their synthesis, and methods of using these compounds to modulate the activity of ASPH in an a cell-free sample, a cell-based assay, and in a subject. Other aspects of the invention relate to use of the compounds disclosed herein to ameliorate or treat cell proliferation disorders.
专利号:US-4369322-A 优先权日:1978-12-15 标 题 :Process for the production of substituted acetonitriles 发明人:SCHALKE PETER; KLEEMANN AXEL 权利人:DEGUSSA 摘要:The known synthesis for the production of aromatic substituted acetonitriles by reaction of aromatic substances with cyanogen chloride in the gas phase is improved by feeding the starting materials in gaseous form and separated from each other into the reactor. The process can be used to synthesize in general aromatic and especially hetero-aromatic substituted acetonitrile.
专利号:EP-3210987-A1 优先权日:2007-08-06 标 题:Process for the synthesis of proteasome inhibitors
专利号:EP-2826772-A1 优先权日:2010-01-26 标题 :Intermediates for the synthesis of oxygen-substituted 3-heteroaroylamino-propionic acid derivatives
专利号:CN-114751882-B 优先权日:2022-03-10 标题:A kind of synthesis method of benzofuran
[参考文献]: Dorus Heijnen, Et Al. Palladium-Catalyzed C(Sp(3))-C(Sp(2)) Cross-Coupling Of (Trimethylsilyl)Methyllithium With (Hetero)Aryl Halides. Org Lett. 2015 May 1;17(9):2262-5. [参考文献]: K L Shepard, Et Al. Topically Active Carbonic Anhydrase Inhibitors. 4. [(Hydroxyalkyl)Sulfonyl]Benzene And [(Hydroxyalkyl)Sulfonyl]Thiophenesulfonamides. J Med Chem. 1991 Oct;34(10):3098-105.