CAS: 501-30-4; 5-Hydroxy-2-(Hydroxymethyl)-4H-Pyran-4-One

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6269-25-6 15771-06-9 54620-67-6

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5-Acetoxy-2-Acetoxymethyl-4H-Pyran-4-One置于sodium Methylate体系中,用 甲醇 作为反应溶剂,化学反应 1.0H,以95%的收率获得产物曲酸
参考文献:将葡萄糖化学酶促三步转化为曲酸.
标题:将葡萄糖化学酶促三步转化为曲酸.
摘要:曲酸是一种重要的生物分子,目前通过发酵生产,具有广泛的潜在应用.一条更快,更直接的化学路线可能为其大规模生产和在生物精炼厂中更广泛的利用打开大门.在这里,我们描述了一种有效的方法,该方法通过三步化学酶法路线,通过葡糖酮从d-葡萄糖制备曲酸.
DOI:10.1039/c9Cc07405H

专利信息

专利号:US-11970456-B1
优先权日:2023-09-21
标题:Synthesis of thiosemicarbazide analogue as inhibitor of tyrosinase, skin hyperpigmentation, and fruit and/or vegetable browning
发明人：BARI AHMED MUHAMMAD; GHANI USMAN
权利人:UNIV KING SAUD
摘要:A 2-((1H-indazol-5-yl)methylene)hydrazinecarbothioamide compound, its synthesis, and its use as a tyrosine kinase inhibitor. In particular, the synthesis of the 2-((1H-indazol-5-yl)methylene)hydrazinecarbothioamide compound as shown below. This compound has a high efficacy of inhibiting mushroom tyrosinase enzyme, and is a potent inhibitor of tyrosinase that can be used as an inhibitor of skin hyperpigmentation as well as an inhibitor of fruit and vegetable browning.

专利号:US-6083976-A
优先权日:1998-01-12
标 题 :Method of synthesis of derivatives of aloesin
发明人：PADMAPRIYA ABEYSINGHE; JONES KENNETH N
权利人:UNIVERA PHARM INC
摘要:The present invention discloses a method for the synthesis of derivatives of aloesin, alkylated at the C-7 hydroxyl group. The present invention includes the modified aloesins produced by the method of this invention and the use of these compounds as skin whitening agents.

专利号:US-7662401-B2
优先权日:2002-04-08
标 题 :Administration of extracts of nonfruiting nonphotosynthetic filamentous bacteria for increasing the endogenous synthesis of superoxide dismutase
发明人：MAHE YANN; MEYBECK ALAIN
权利人:OREAL
摘要:The present invention relates to the cosmetic or pharmaceutical use of an extract of a nonfruiting nonphotosynthetic filamentous bacterium in a composition containing a cosmetically or pharmaceutically acceptable medium, as an agent increasing the endogenous synthesis of superoxide dismutase, in particular for preventing and/or limiting the formation of free radicals and/or removing the free radicals present in cells; in addition, the invention relates to a composition comprising at least one extract of Vitreoscilla filiformis and lycopene.

专利号:US-6123959-A
优先权日:1998-04-24
标题:Aqueous composition comprising active ingredients for the de-pigmentation of the skin
发明人：JONES KENNETH; PADMAPRIYA ABEYSINGHE; TEICHMUELLER ERNST E; BLUME GABRIELE
权利人:UNIVERA PHARM INC; ROVI GMBH
摘要:The present invention discloses aqueous compositions comprising liposomes of phospholipids, and at least one competitive inhibitor of an enzyme for the synthesis of melanin, in combination with at least one non-competitive inhibitor of an enzyme for the synthesis of melanin. The invention also includes the use of the compositions of this invention for the de-pigmentation of skin.

专利号:US-2024009104-A1
优先权日:2021-02-09
标 题:Process for extraction and hemi-synthesis of pyranoanthocyanins and skincare cosmetic formulations containing them
发明人：REIS FERNANDES IVA LUZIA; DA SILVA OLIVEIRA PINTO DA SILVA JOANA ALEXANDRA; DA CRUZ BATISTA MATEUS NUNO FILIPE; PEREIRA DE FREITAS VICTOR ARMANDO; COUTO OLIVEIRA HELDER JOSÉ; CARNEIRO ARAUJO PAULA ALEXANDRA; RODRIGUES CORREIA PATRICIA; MARTINS PEREIRA ANA RITA
权利人:UNIV DO PORTO; REQUIMTE REDE DE QUIM E TECNOLOGIA
摘要:A process of extraction of anthocyanins from different foodstuffs or by-products, and their conversion into pyranoanthocyanins compounds, which can be used as pigments having new colors and improved stability to be incorporated into skincare formulations in particular anti-ageing and sun-protection formulations. Cosmetic formulations having the pigments with improved properties of UV protection and moisturizing, anti-dark spots, anti-wrinkles and wound-healing, which can be associated with interesting colors ranging from red to blue depending on the selected pigments in the composition and in the formula composition. The present invention is in the area of organic chemistry, biochemistry, pharmacology and cosmetics for skincare.

专利号:US-6264962-B1
优先权日:1997-12-19
标 题:Use of cinnamic acid or of at least one of its derivatives in a cosmetic composition
发明人：BRETON LIONEL; GIRERD FLORENCE; RENAULT BEATRICE
权利人:OREAL
摘要:The invention relates to the use of cinnamic acid, or of at least one of its derivatives, in a cosmetic composition as an agent for promoting the synthesis of the skin's total lipids. n The invention also relates to a cosmetic composition comprising an effective amount of cinnamic acid or of at least one of its derivatives.