CAS: 69922-28-7; 5-Isocyanatobenzo[d][1,3]Dioxole

上下游产品

CAS号32315-10-9 三光气 | CAS号14268-66-7 3,4-亚甲二氧基苯胺 | CAS号75-44-5 光气 | CAS号70156-94-4 N-hydroxy-1,3-b... | CAS号94-53-1 胡椒酸 | CAS号25054-53-9 胡椒酸酰氯 | CAS号503-38-8 氯甲酸三氯甲酯 | CAS号698984-83-7 4-Morpholinecar...

胡椒酸 反应生成 3,4-(甲二氧基)异氰酸苯酯
参考文献:三丁基氢化锡自由基反应合成与硅环己烷环稠合的n-甲基菲啶酮衍生物
标题:三丁基氢化锡自由基反应合成与硅环己烷环稠合的n-甲基菲啶酮衍生物
摘要:(N-Methyl-7-Bromo-2,2-Dimethyl-2-Silatetralin-6-Ylamino)Veratraamide (8A) 和-Piperonamides (8B) 在沸腾的苯中使用氢化三丁基锡和 Aibn 进行自由基反应,得到两种 N-甲基菲啶酮衍生物(15 和 16),它们在芳酸部分的 6 位和 2 位环化.另一方面,N-甲基-N-(2-溴代甲基和2-溴哌啶基)-2,2-二甲基-2-Silatetralin-6-Carboxamides (14) 的类似反应分别产生 N-甲基菲啶酮衍生物 (17)唯一的产物,其中环化发生在 2-Silatetralin 部分的 5 位.
DOI:10.3987/com-05-S(K)64

专利信息

专利号:US-9879050-B2
优先权日:2013-08-30
标 题 :Substituted urea depsipeptide analogs as activators of the CLPP endopeptidase
发明人：LEE RICHARD E; ZHAO YING; GRIFFITH ELIZABETH; ZHENG ZHONG; SINGH AMAN P
权利人:ST JUDE CHILDREN'S RES HOSPITAL
摘要:In one aspect, the invention relates to substituted urea depsipeptide analogs, derivatives thereof, and related compounds, which are useful as activators the ClpP endopeptidease; synthesis methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating infectious disease using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

专利号:US-9833457-B2
优先权日:2008-01-25
标题:Tricyclic compounds as modulators of TNF-α synthesis and as PDE4 inhibitors
发明人：MJALLI ADNAN M M; GADDAM BAPU; POLISETTI DHARMA RAO; KOSTURA MATTHEW J; GUZEL MUSTAFA
权利人:VTV THERAPEUTICS LLC
摘要:The present invention relates to chemical compounds of Formula (I) are as herein defined, pharmaceutical compositions, and methods of use in the treatment of conditions or disorders mediated by TNF-α or by PDE4, including but not limited to psoriatic arthritis.

专利号:US-2015038591-A1
优先权日:2002-05-31
标 题:Compounds, compositions and methods for the treatment of tauopathies
发明人：SNOW ALAN D; CAM JUDY A; CASTILLO GERARDO; HU QUBAI; LAKE THOMAS
权利人:PROTEOTECH INC
摘要:Bis- and tris-dihydroxyaryl compounds and their methylenedioxy analogs and pharmaceutically acceptable esters, their synthesis, pharmaceutical compositions containing them, and their use in the treatment of tauopathies, such as Alzheimer's disease and Parkinson's disease, and the manufacture of medicaments for such treatment.

专利号:US-7919530-B2
优先权日:2002-05-31
标 题 :Compounds, compositions, and methods for the treatment of synucleinopathies
发明人：ESPOSITO LUKE A; CUMMINGS JOEL; HUDSON F MICHAEL; SNOW ALAN D
权利人:PROTEOTECH INC
摘要:Bis- and tris-dihydroxyaryl compounds and their methylenedioxy analogs and pharmaceutically acceptable esters, their synthesis, pharmaceutical compositions containing them, and their use in the treatment of synucleinopathies, such as Parkinson's disease, and the manufacture of medicaments for such treatment.

专利号:US-10570179-B2
优先权日:2016-09-02
标 题:Substituted urea depsipeptide analogs as activators of the CLPP endopeptidase
发明人：LEE RICHARD E; ZHAO YING
权利人:ST JUDE CHILDRENS RES HOSPITAL
摘要:In one aspect, the invention relates to substituted urea depsipeptide analogs, derivatives thereof, and related compounds, which are useful as activators the ClpP endopeptidease; synthesis methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating infectious disease using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

专利号:US-7601876-B2
优先权日:2002-05-31
标题 :Compounds, compositions and methods for the treatment of amyloid diseases such as systemic AA amyloidosis
发明人：SNOW ALAN D; NGUYEN BETH P; CASTILLO GERARDO M; SANDERS VIRGINIA J; LAKE THOMAS P; LARSEN LESLEY; WEAVERS REX T; LORIMER STEPHEN D; LARSEN DAVID S; COFFEN DAVID L; COFFEN CHARLOTTE
权利人:PROTEOTECH INC
摘要:Bis- and tris-dihydroxyaryl compounds and their methylenedioxy analogs and pharmaceutically acceptable esters, their synthesis, pharmaceutical compositions containing them, and their use in the treatment of amyloid diseases, especially Aβ amyloidosis, such as observed in Alzheimer's disease, IAPP amyloidosis, such as observed in type 2 diabetes, AA/SAA amyloidosis, such as observed in systemic AA amyloidosis and synucleinopathies, such as observed in Parkinson's disease, and the manufacture of medicaments for such treatment.