CAS: 78068-85-6; 3-Chloro-4-Fluorobenzotrifluoride

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CAS号328-84-7 3,4-二氯三氟甲苯 | CAS号39885-50-2 3-氯-4-氨基三氟甲苯 | CAS号129931-45-9 3-氯-2-氟-5-(三氟甲基)苯甲酸 | CAS号80175-36-6 5-[2-chloro-4-(... | CAS号78747-70-3 3-[2-chloro-4-(... | CAS号89634-76-4 1-chloro-2-fluo... | CAS号55407-28-8 4-[2-chloro-4-(...

3,4-二氯三氟甲苯置于potassium Fluoride,四苯基氯化膦体系中,用 N,N-二甲基乙酰胺 作为反应溶剂,以90%的收率获得产物3-氯-4-氟三氟甲苯
参考文献:一种无金属催化剂制备氟胺氰菊酸的方法
标题:一种无金属催化剂制备氟胺氰菊酸的方法
摘要:本发明公开了一种无金属催化剂制备氟胺氰菊酸的方法,包括以下步骤:3,4-二氯-三氟甲苯,氟化钾在有机溶剂中,在0-200oc下加入催化剂进行选择性氟化反应制备3-氯-4-氟-三氟甲苯;得到的3-氯-4-氟-三氟甲苯与d-缬氨酸在有机溶剂进行脱氟偶联反应,最终得到氟胺氰菊酸.本发明制备氟胺氰菊酸的方法,催化剂为季铵盐,季膦盐或冠醚等无金属催化剂,是一种先选择性氟化,再脱氟偶联制备氟胺氰菊酸的方法,其中第二步偶联产生的氟化钾套用回下一批第一步的氟化中以降低三废,使生产,储运等各环节更加安全,方便,且生产成本较低,总收率>85%及含量>95%,原料均无毒或低毒,有利于工业化.

专利信息

专利号:US-6156922-A
优先权日:1995-12-28
标题 :Method for the synthesis of an aromatic derivative ortho-disubstituted by a halogen atom other than fluorine and by a cyano group
发明人：RUSSELL JAMES; GILBERT LAURENT; MAESTRO JEAN PIERRE
权利人:RHODIA CHIMIE SA
摘要:PCT No. PCT/FR96/02100 Sec. 371 Date Sep. 15, 1998 Sec. 102(e) Date Sep. 15, 1998 PCT Filed Dec. 27, 1996 PCT Pub. No. WO97/24318 PCT Pub. Date Jul. 10, 1997The present invention relates to a method for the synthesis of a halogen substituted aryl nitrile, where the halogens are selected from Cl, Br, or I, by reacting an aryl dihalide with a halogen/fluoride exchange reactant to produce a halogen substituted aryl fluoride which is then reacted with a fluoride/cyanide exchange reactant to produce the halogen substituted aryl nitrile.

专利号:US-4575571-A
优先权日:1983-06-23
标题:Process for the simultaneous halogenation and fluorination of aromatic derivatives
发明人：DESBOIS MICHEL; DISDIER CAMILLE
权利人:RHONE POULENC SPEC CHIM
摘要:A process for the stimulaneous halogenation and fluorination of aromatic derivatives substituted by at least one group containing a halogenoalkyl unit. The aromatic derivative is reacted with the halogen in liquid hydrofluoric acid. The products obtained are useful as intermediates for the synthesis of compounds having a plant-protecting or pharmaceutical activity.