CAS: 784-04-3; 9-Acetylanthracene

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CAS号120-12-7 蒽 | CAS号75-36-5 乙酰氯 | CAS号64-19-7 冰醋酸 | CAS号13752-40-4 9-炔基蒽 | CAS号108-24-7 乙酸酐 | CAS号1564-64-3 9-溴蒽 | CAS号66398-74-1 9-(1-hydroxy-1-... | CAS号24100-41-2 Ethanone,1-(9-a... | CAS号24100-41-2 Ethanone,1-(9-a... | CAS号68941-23-1 9-(α-Bromvinyla... | CAS号90-44-8 蒽酮 | CAS号84-65-1 蒽醌 | CAS号10210-32-9 2-乙酰基蒽 | CAS号120-12-7 蒽 | CAS号10210-34-1 1-(5-acetylanth...

9-乙炔基蒽置于ferric Sulfate Heptahydrate,溶剂黄146体系中,化学反应 24.0H,以54%的收率获得产物9-乙酰基蒽
参考文献:硫酸铁(iii)水合物在无氯条件下水合芳烃末端炔烃
标题:硫酸铁(iii)水合物在无氯条件下水合芳烃末端炔烃
摘要:在催化水合硫酸铁iii铁,Fe 2(so 4)3 . N H 2的存在下,在乙酸中进行芳族末端炔的水合反应o(4-9 Mol%),可反应生成衍生的芳基甲基酮,收率好至极好.在可比较的条件下(18 Mol%,95°C,24小时),根据芳族二炔的结构,将双功能底物转化为单乙酰基或二乙酰基衍生物.该反应与具有不同性质和环位置的芳基取代基相容,包括羟基,羰基和累积的烃.非亲核硫酸根阴离子的柔软特性可以使三键在布朗斯台德酸性介质中朝形成碳氧键的方向活化.所提出的方案基于容易获得且无毒的材料,在溶剂或金属催化剂中均不存在氯原子.
DOI:10.1016/j.Tetlet.2014.01.083

专利信息

专利号:EP-1730108-B1
优先权日:2004-03-18
标 题:Stereoselective synthesis of vitamin d analogues
发明人：SABROE THOMAS PETER; CALVERLEY MARTIN JOHN
权利人:LEO PHARMA AS
摘要:The present invention relates to intermediates useful for the synthesis of calcipotriol or calcipotriol monohydrate, to methods of producing said intermediates, and to methods of stereoselectively reducing said intermediates.

专利号:EP-1735276-B1
优先权日:2004-04-02
标题:Novel method for the preparation of intermediates useful for the synthesis of vitamin d analogues
发明人：HANSEN ERIK TORNGAARD; SABROE THOMAS PETER; CALVERLEY MARTIN JOHN; PEDERSEN HENRIK; DEUSSEN HEINZ-JOSEF WILHELM
权利人:LEO PHARMA AS
摘要:The present invention relates to novel methods for the preparation of intermediates which are useful in the synthesis of cacipotriol. The present invention relates further to the use of intermediates produced with said methods for making calcipotriol or calcipotriol monohydrate.

专利号:US-8759555-B2
优先权日:2004-03-18
标 题:Stereoselective synthesis of vitamin D analogues
发明人：SABROE THOMAS PETER; CALVERLEY MARTIN JOHN
权利人:SABROE THOMAS PETER; CALVERLEY MARTIN JOHN; LEO PHARMA AS
摘要:The present invention relates to intermediates useful for the synthesis of calcipotriol or calcipotriol monohydrate, to methods of producing said intermediates, and to methods of stereoselectively reducing said intermediates.

专利号:RU-2378252-C2
优先权日:2004-04-02
标题 :Novel method for synthesis of intermediate compounds, used in synthesis of vitamin d analogues

专利号:US-2007027333-A1
优先权日:2004-03-18
标题 :Stereoselective synthesis of vitamin d analogues

专利号:CA-2555260-C
优先权日:2004-03-18
标 题 :Stereoselective synthesis of vitamin d analogues