CAS: 79-19-6; Thiosemicarbazide

相似化合物

4346-94-5 2231-57-4 142-46-1

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二硫化碳置于ammonium Hydroxide,肼体系中,化学反应生成 氨基硫脲
参考文献:设计,合成和生物学评估新型半碳水化合物-硒代色氮-4-酮杂化物作为有效的抗真菌剂.
标题:设计,合成和生物学评估新型半碳水化合物-硒代色氮-4-酮杂化物作为有效的抗真菌剂.
摘要:通过分子杂交的方法,设计合成了一系列新颖的2,3-二氢-4 H-1-苯并硒啉-4-酮(硫代)半碳zone酮衍生物.所有目标化合物均通过hrms和NMR进行了表征,并针对五种病原菌株评估了其体外抗真菌活性.与前体硒代苯并二氢吡喃-4-酮相比,本研究中的杂化分子显示出显着的抗真菌活性.值得注意的是,化合物b8对除烟曲霉以外的其他菌株均表现出显着的抗真菌活性(白色念珠菌为0.25μg/ Ml,新隐球菌为2μg/ Ml,玉米芽孢杆菌为8μg / Ml).氟康唑敏感菌株白色念珠菌(candida Albicans)的浓度为2μg/ Ml).此外,化合物b8,B9和c2还显示出对四种氟康唑耐药菌株的最有效活性.特别地,杂合分子b8对耐氟康唑的菌株的mic值在0.5-2μg/ Ml的范围内.因此,本研究中的分子杂交方法为抗真菌药物的开发提供了新思路.
DOI:10.1016/j.Bmcl.2019.126726

专利信息

专利号:US-2022411943-A1
优先权日:2021-06-23
标 题 :Process for the Electrochemical Synthesis of Green Urea, an Electrochemical Cell for the Electrochemical Synthesis of Green Urea and the Green Urea Produced Thereby
发明人：GHORAI UTTAM KUMAR; MUKHERJEE Jit; PAUL SOURAV; ADALDER ASHADUL
权利人:GHORAI UTTAM KUMAR; RAMAKRISHNA MISSION VIDYAMANDIRA
摘要:This invention relates to a process for the electrochemical synthesis of green urea, and the urea produced thereby. The electrochemical synthesis of urea involves the reduction of dual purging gases N 2 and CO 2 via six electron transfer process (N 2 +CO 2 +6H + +6e − →CO (NH 2 ) 2 +H 2 O) & reduction of the NO 3 − ions and CO 2 via sixteen electron transfer process (2NO 3 −+CO 2 +18H + +16e − →CO(NH 2 ) 2 +7H 2 O) under ambient condition using copper phthalocyanine (CuPc) catalyst. The binding of two intermediate products during dual reduction simultaneously, leads to the production of urea in water medium under ambient conditions.

专利号:US-11970456-B1
优先权日:2023-09-21
标题:Synthesis of thiosemicarbazide analogue as inhibitor of tyrosinase, skin hyperpigmentation, and fruit and/or vegetable browning
发明人：BARI AHMED MUHAMMAD; GHANI USMAN
权利人:UNIV KING SAUD
摘要:A 2-((1H-indazol-5-yl)methylene)hydrazinecarbothioamide compound, its synthesis, and its use as a tyrosine kinase inhibitor. In particular, the synthesis of the 2-((1H-indazol-5-yl)methylene)hydrazinecarbothioamide compound as shown below. This compound has a high efficacy of inhibiting mushroom tyrosinase enzyme, and is a potent inhibitor of tyrosinase that can be used as an inhibitor of skin hyperpigmentation as well as an inhibitor of fruit and vegetable browning.

专利号:US-6451543-B1
优先权日:1998-08-31
标题:Lipid matrix-assisted chemical ligation and synthesis of membrane polypeptides
发明人：KOCHENDOERFER GERD G; HUNTER CHRISTIE L; KENT STEPHEN B H; BOTTI PAOLO
权利人:GRYPHON SCIENCES
摘要:The present invention relates to methods and compositions for lipid matrix-assisted chemical ligation and synthesis of membrane polypeptides that are incorporated in a lipid matrix. The invention is exemplified in production of a prefolded membrane polypeptide embedded within a lipid matrix via stepwise chemoselective chemical ligation of unprotected peptide segments, where at least one peptide segment is embedded in a lipid matrix. Any chemoselective reaction chemistry amenable for ligation of unprotected peptide segments can be employed. Suitable lipid matrices include liposomes, micelles, cell membrane patches and optically isotropic cubic lipidic phase matrices. Prefolded synthetic and semi-synthetic membrane polypeptides synthesized according to the methods and compositions of the invention also permit site-specific incorporation of one or more detectable moieties, such as a chromophore, which can be conveniently introduced during synthesis. The methods and compositions of the invention have multiple uses. For example, they can be used to assay ligand binding to membrane polypeptides and domains comprising a receptor, and thus are extremely useful for structure/function studies, drug screening/selection/design, and diagnostics and the like, including high-throughput applications. The methods and compositions of the invention are particularly suited for FRET analyses of previously inaccessible membrane polypeptides.

专利号:US-6998484-B2
优先权日:2000-10-04
标 题:Synthesis of purine locked nucleic acid analogues
发明人：KOCH TROELS; JENSEN FLEMMING REISSIG
权利人:SANTARIS PHARMA AS
摘要:The present invention relates to a new method for the synthesis of purine LNA (Locked Nucleic Acid) analogues which provides a higher overall yield. The method comprising a regioselective 9-N purine glycosylation reaction followed by a one-pot nucleophilic aromatic substitution reaction of the 6-substituent in the purine ring and simultaneous nucleophile-induced intramolecular ring closure of the C-branched carbohydrate to form novel purine LNA analogues. The novel strategy is illustrated by the synthesis of the novel compound (1S,3R,4R,7S)-7-benzyloxy-1-methanesulfonylmethyl-3-(guanin-9-yl)-2,5-dioxabicyclo[2.2.1]heptane which is easily converted into (1S,3R,4R,7S)-7-hydroxy-1-hydroxymethyl-3-((2-N-isobutyrylguanin-9-yl)-2,5-dioxabicyclo[2.2.1]heptane after isobutyryl protection of the 2-amino purine group and subsequent substitution of 1-methanesulfonyl with benzoate, debenzoylation and debenzylation.

专利号:US-11292775-B2
优先权日:2017-12-21
标 题 :Efficient process for the synthesis of 2-[2-(1-chlorocyclopropyl)-3-(2-chlorophenyl)-2-hydroxypropyl]-2,4-dihydro-3H-1,2,4-triazole-3-thione(prothioconazole) and its intermediates
发明人：KADAM SUBHASH RAJARAM; JANI NILESH; SHINDE RAVINDRA; SHAH KENAL V; SHAH BHAVESH V; GUJRAL AJIT SINGH; BYREGOWDA GANGANARASAIAH; SIVAIAH GANADI; PAWAR JIVAN DHANRAJ; PATI HARI NARAYAN
权利人:GSP Crop Science Pvt Ltd
摘要:The present invention relates to an improved and efficient process for the synthesis of 2-[2-(1-chlorocyclopropyl)-3-(2-chlorophenyl)-2-hydroxypropyl]-2,4-dihydro-3H-1,2,4-triazole-3-thione, compound of formula (I) (Prothioconazole). The present invention more particularly relates to an improved process for manufacturing of 2-(1-chloro-cycloprop-1-yl)-3-(2-chloro phenyl)-2-hydroxy propyl-1-hydrazine (compound of formula III) and 2-[2-(1-chlorocyclopropyl)-3-(2-chlorophenyl)-2-hydroxypropyl]-1,2,4-triazolidine-3-thione (compound of formula II) which are mainly used for synthesis of Prothioconazole which is knows as an active compound with microbicidal fungicidal properties.

专利号:US-10793495-B2
优先权日:2015-08-14
标 题:Synthesis of polyaryl substituted aryl compounds
发明人：BOULOS RAMIZ; FEUTRILL JOHN
权利人:BOULOS & COOPER PHARMACEUTICALS PTY LTD
摘要:A method for the synthesis of a aryl compound of Formula (1).n nU T-W—R 1 ) n    (1)