CAS: 961-69-3; Potassium (R)-2-((4-Ethoxy-4-Oxobut-2-En-2-yl)Amino)-2-Phenylacetate

专利信息

专利号:US-9126896-B2
优先权日:2012-06-01
标题:Synthesis of diamido gellants by using Dane salts of amino acids
发明人：BINDL MARTIN; HERRMANN ROLAND; KNAUP GUNTER
权利人:EVONIK INDUSTRIES AG
摘要:The invention relates to a method for the synthesis of a compound according to formula I comprising the following steps: a) reacting a Dane salt according to formula II and a Dane salt according to formula III with a coupling reagent; b) adding a diamine according to formula IV to the reaction mixture; and c) adding an acid to the reaction mixture to adjust the pH value of the reaction to <7; wherein L represents a C 2 -C 20 alkyl group, a C 6 -C 20 aryl group, or a C 7 -C 20 alkylaryl group; R 1 and R 2 can be identical or different and represent a hydrogen atom, a C 1 -C 4 alkyl group, a C 1 -C 4 hydroxyalkyl group, a C 1 -C 4 thioether group, a C 6 -C 20 aryl group, a C 7 -C 20 alkylaryl group, a C 7 -C 20 alkylhydroxyaryl group, a C 4 -C 20 alkylheteroaryl group with 1 to 4 heteroatoms; or a C 1 -C 4 alkylcarboxylic moiety, which may be an acid, an amide, or which may be esterified with a C 1 -C 6 alkyl group or a C 7 -C 20 alkylaryl group; R 3 represents a C 1 -C 4 alkyl group; R 4 represents a hydrogen atom, or a C 1 -C 4 alkyl group; R 5 represents a C 1 -C 4 alkyl group; and X represents an alkali metal.

专利号:US-2003044884-A1
优先权日:2000-10-11
标题:Synthesis of beta-lactam antibacterials using soluble side chain esters and enzyme acylase
发明人：USHER JOHN J; ROMANCIK GUNA
摘要:Disclosed is a process for the synthesis of β-lactam antibacterials using soluble side chain esters in the presence of enzyme acylase. Also disclosed are novel esters useful as reactants in said process.

专利号:US-4440682-A
优先权日:1981-04-06
标 题:Stereospecific synthesis of isocephalosporins and 2-oxa isocephalosporins
发明人：BOSE AJAY K; FERNANDEZ ISABEL F; GALA KANTI J
权利人:LAFARQUIM
摘要:A process is described whereby a synthetically produced 4-styryl-cis-3,4-azetidinone is converted to an isocephalosporin or its 2-oxa analog. The process is based upon the condensation of enamine and imine synthons. Novel intermediate azetidinones are also disclosed. Control of the stereochemical course of the process allows economical, high yield preparation of the racemic form of the product or when a single enantiomer of the imine synthon derived from the β-hydroxy-α-amino acid starting material is used, both enantiomers of the product may be prepared and separated without optical resolution.

专利号:WO-8800941-A1
优先权日:1986-08-08
标 题:ASYMETRIC SYNTHESIS OF ENANTIOMERICALLY PURE MONOCLYCLIC beta-LACTAM INTERMEDIATES
发明人：THOMAS RICHARD C
权利人:UPJOHN CO
摘要:Monocyclic beta-lactam intermediates and process for their preparation. The compounds of the present invention are of formula (I), and are useful as intermediate for preparing highly active C-4 substituted monobactams.

专利号:WO-8302942-A1
优先权日:1982-02-19
标 题 :Process for preparing 2-azetidinone-1-sulfonic acids, and starting materials therefor
发明人：YOSHIOKA KOUICHI; OCHIAI MICHIHIKO
权利人:TAKEDA CHEMICAL INDUSTRIES LTD
摘要:Compounds having the general formula: $ (4,) $ (in which R represents an organic residue linked by a carbon atom, and Z + represents an oleophilic quaternary ammonium group), and process for the preparation of a 2-azetidinone-1 acid -sulfonic, advantageous intermediate in the synthesis of an antibacterial agent having excellent antibacterial and inhibitory effects of beta-lactamase, represented by the general formula: $ (5,) $ (in which R and Z + have the same definition as above, and R1 represents a protected or acylated amino group or an azido group), which consists in reacting the compound (II) with a reactive derivative of a carboxylic acid represented by the general formula: $ (3,) $ (in which R1 has the same definition as above).

专利号:CA-2253521-A1
优先权日:1996-07-26
标 题:Synthesis of .beta.-lactam antibacterials using soluble side chain esters and enzyme acylase