CAS: 1056459-37-0; 5-(5-Chloro-1-(2-Fluorophenyl)-2-Oxopentyl)-4,5,6,7-Tetrahydrothieno[3,2-C]Pyridin-2-Yl Acetate

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6,7-dihydro-4H-thieno[3,2-c]pyridine hydr°Chloride 1-cyclopropyl-2-(2-fluorophenyl)ethanone N-trityl-4,5,6,7-tetrahydrothieno[2,3-c]pyridine 5,6,7,7a-tetrahydro-4H-thieno[3,2-c]pyridine-2-one p-toluenesulfonate 2-acetoxy-5-[5-chIoro-1-(2-fluorophenyl)pentyl]-4,5,6,7-tetrahydro-4H-thieno[3,2-c] pyridine maleate 5-(5-chloro-1-(2-fluorophenyl)-2-oxopentyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridin-2-yl acetate hydr°Chloride

4,5,6,7-四氢噻吩[3,2-C]吡啶盐酸盐置于正丁基锂,N,N-二异丙基乙胺体系中,用 四氢呋喃,正己烷,N,N-二甲基甲酰胺,乙腈 用作溶剂,化学反应 14.0H,反应生成1-[2-(乙酰氧基)-6,7-二氢噻吩并[3,2-C]吡啶-5(4H)-基]-1-(3-氟苯基)-5-氯-2-戊酮
参考文献: Method For Preparing Pharmaceutically Active Ingredient And Intermediates Thereof[fr] Procédé De Préparation D'Une Substance Pharmaceutiquement Active Et De Ses Intermédiaires
标题: Method For Preparing Pharmaceutically Active Ingredient And Intermediates Thereof[fr] Procédé De Préparation D'Une Substance Pharmaceutiquement Active Et De Ses Intermédiaires
摘要:本发明涉及一种安全且适用于工业生产的方法,用于制备2-乙酰氧基-5-(2-氟-α-环丙基-羰基苄基)-4,5,6,7-四氢-4H-噻吩[3,2-C]吡啶,其质量适合用作药用活性成分,其中减少了公式(xxiv)或(xxiva)的杂质浓度.