CAS: 158966-92-8; (R,E)-2-(1-(((1-(3-(2-(7-Chloroquinolin-2-yl)Vinyl)Phenyl)-3-(2-(2-Hydroxypropan-2-yl)Phenyl)Propyl)Thio)Methyl)Cyclopropyl)Acetic Acid

上下游产品

CAS号866923-62-8 2-(1-((((R)-1-(... | CAS号1015076-80-8 (1-{1-(R)-(3-br... | CAS号177748-00-4 7-氯-2-乙烯喹啉 | CAS号1124196-05-9 phenylhydrazine... | CAS号1100021-03-1 1-(((1(R)-(3-(2... | CAS号287930-77-2 2-[3-(S)-[3-(2-... | CAS号162515-68-6 1-巯甲基环丙基乙酸 | CAS号855473-51-7 Montelukast Met... | CAS号151767-02-1 孟鲁司特钠 | CAS号577953-88-9 孟鲁司特二环己胺 | CAS号577953-88-9 孟鲁司特二环己胺 | CAS号151767-02-1 孟鲁司特钠

2-[2-[3(S)-[3-(7-氯-2-喹啉基)乙烯基]苯基]-3-羟基丙基]苯基-2-丙醇置于sodium Methylate,溶剂黄146,N,N-二异丙基乙胺体系中,用 甲醇,甲基叔丁基醚,重水,乙酸乙酯,乙腈 用作溶剂,化学反应 25.0H,反应生成孟鲁司特
参考文献: Processes For Preparation Of Montelukast Sodium And Purification Of Diol Intermediate[fr] Méthodes De Préparation De Montélukast De Sodium Et De Purification D'Un Intermédiaire Diol
标题: Processes For Preparation Of Montelukast Sodium And Purification Of Diol Intermediate[fr] Méthodes De Préparation De Montélukast De Sodium Et De Purification D'Un Intermédiaire Diol
摘要:提供一种通过新颖的蒙特鲁卡斯特胺盐制备蒙特鲁卡斯特钠的方法,其中所选的胺来自1-(1-萘基)乙胺,S-甲基-L-半胱氨酸,二烯基胺或其异构体.还提供了一种用卤代烃和腈作用作溶剂的纯化2-(2-(3-(S)-(3-(7-氯-2-喹啉基)-乙烯基)苯基)-3-羟基丙基)-苯基-2-丙醇的方法.

专利信息

专利号:US-2012215002-A1
优先权日:2009-10-09
标 题:Synthesis of optically active intermediate for the preparation of montelukast
发明人：LEFORT LAURENT
权利人:LEFORT LAURENT
摘要:The present invention relates to the synthesis of optically active alcohols by means of enantioselective hydrogenation of ketones in biphasic systems. In particular the present invention relates to the synthesis of an optically active alcohol of general formula (1).

专利号:WO-2004099229-A1
优先权日:2003-05-06
标题:Process for the synthesis of base addition salts of 2,3-0-isopropylidene-1-0-substituted-5,6-dideoxy-5-n- (4-(2-hydroxy-2-oxoethyl)-phenylaminocarbonyl) amino-l-gulofuranosides
发明人：KHANNA JAG MOHAN; YADAV GYAN CHAND; RAY ABHIJIT; KRISHNA NARUGANAHALLI SIDDARAN
权利人:RANBAXY LAB LTD; KHANNA JAG MOHAN; YADAV GYAN CHAND; RAY ABHIJIT; KRISHNA NARUGANAHALLI SIDDARAN
摘要:The present invention relates to processes for the synthesis of base addition salts of particular ß-L- gulofuranosides. More specifically, the invention relates to synthetic processes for making base addition salts of 2,3-O-isopropylidene-1-O-substituted-5,6-dideoxy-5-N-[4-(2-hydroxy-2-oxoethy)-phenylaminocarbony]amino-ß-L-gulofuranosides.

专利号:WO-2008035086-A3
优先权日:2006-09-22
标 题:Synthesis of leukotriene compounds
发明人：WIFFEN JONATHAN; WILSON IAN
权利人:ALMAC SCIENCES LTD; WIFFEN JONATHAN; WILSON IAN
摘要:The present invention relates to the synthesis of leukotriene receptor agonist compounds and to novel intermediates employed in their preparation. Leukotriene agonists are used in the treatment of asthma, as well as other conditions mediated by leukotrienes such as inflammation and allergies. A compound of particular interest is montelukast and the present invention describes an improved process for making montelukast and similar compounds.

专利号:WO-2023169082-A1
优先权日:2022-10-24
标 题:Synthesis method and application of benzothiadiazole-1-ketone compound and derivative thereof
发明人：YI WEI; ZHOU ZHI; WU LIEXIN
权利人:UNIV GUANGZHOU MEDICAL
摘要:Disclosed in the present invention are a synthesis method and application of a benzoselenazole-1-ketone compound and a derivative thereof. Sulfoximine and the element selenium are used as raw materials, and by means of a rhodium catalysis direct C-H functionalization reaction, synthesis of a series of benzoselenazole-1-ketone compounds is achieved. The solution has the advantages of strong functional group compatibility, wide substrate universality, mild conditions, simple operations, and high efficiency and universality. Meanwhile, sulfoximine and the element selenium are used as initial raw materials, a direct C-H functionalization reaction is carried out, and by means of chiral phosphoric acid, synthesis of the chiral benzoselenazole-1-ketone compound is achieved. The application prospect is good, and a sulfydryl structure in biomacromolecules such as polypeptides, saccharides, drug molecules and proteins can be specifically marked. Good anti-SARS-CoV-2 virus activity is exhibited, a trastuzumab biological conjugate can effectively image HER 2 receptors on the cell surface, displays strong fluorescence, and can be applied to the preparation of an imaging reagent for the HER 2 receptor on the cell surface.

专利号:US-2025206743-A1
优先权日:2022-03-25
标 题:Tyk2 inhibitor synthesis and intermediates thereof
发明人：MASSE CRAIG E; PHADKE AVINASH S; LAWSON JON P; LEVY STUART; YANG XIAOWEI; WU GUISHENG; FAN SHUFENG
权利人:TAKEDA PHARMACEUTICALS CO
摘要:Described herein are methods of synthesis of a tyrosine-protein kinase 2 (TYK2) inhibitor and to intermediate compounds of the synthesis and methods of making the intermediates. Also provided are pharmaceutically acceptable compositions including compounds prepared by the synthetic method and methods of treating disorders using the same.

专利号:US-8263755-B2
优先权日:2006-11-20
标题:Synthesis of compounds useful as modulators of amyloid-beta production
发明人：FINDEIS MARK A
权利人:FINDEIS MARK A; SATORI PHARMACEUTICALS INC
摘要:As described herein, the present invention provides methods for preparing compounds useful for treating or lessening the severity of a neurodegenerative disorder. The present invention also provides methods of treating or lessening the severity of such disorders wherein said method comprises administering to a patient a compound of the present invention, or composition thereof. Said method is useful for treating or lessening the severity of, for example, Alzheimer's disease.