专利号:EP-1108724-B1 优先权日:1996-01-16 标题 :Synthesis of methoxy nucleosides and enzymatic nucleic acid molecules 发明人:WINCOTT FRANCINE; BEIGELMANN LEONID; MATULIC-ADAMIC JASENKA; USMAN NASSIM; HAEBERLI PETER; KARPEISKY ALEXANDER; SWEEDLER DAVID; JARVIS THALE; DIRENZO ANTHONY 权利人:SIRNA THERAPEUTICS INC 摘要:This invention relates to chemical synthesis of 2'-O-methyl, 3'-O-methyl and 5'-O-methyl nucleosides, incorporation of novel chemical modifications in enzymatic nucleic acid molecules and improved methods for the synthesis of enzymatic nucleic acid molecules.
专利号:US-6972330-B2 优先权日:1996-02-13 标题:Chemical synthesis of methoxy nucleosides 发明人:BEIGELMAN LEONID; HAEBERLI PETER; KARPEISKY ALEXANDER; SWEEDLER DAVID 权利人:SIRNA THERAPEUTICS INC 摘要:Process for chemical synthesis of methoxy nucleosides.
专利号:US-6413957-B1 优先权日:1998-04-21 标题:Methods of inhibiting cell proliferation using indeno [1,2-c]pyrazol-4-ones 发明人:NUGIEL DAVID A; CARINI DAVID J; DI MEO SUSAN V; YUE EDDY W 权利人:BRISTOL MYERS SUIBB PHARMA COM 摘要:The present invention relates to the synthesis of a new class of indeno[1,2-c]pyrazol-4-ones of formula (I): n that are potent inhibitors of the class of enzymes known as cyclin dependent kinases, which relate to the catalytic subunits cdk1-7 and their regulatory subunits know as cyclins A-G. This invention also provides a novel method of treating cancer or other proliferative diseases by administering a therapeutically effective amount of one of these compounds or a pharmaceutically acceptable salt form thereof. Alternatively, one can treat cancer or other proliferative diseases by administering a therapeutically effective combination of one of the compounds of the present invention and one or more other known anti-cancer or anti-proliferative agents.
专利号:US-8642798-B2 优先权日:2004-12-07 标 题:Silacycle compounds and methods of use thereof 发明人:LEIGHTON JAMES LINCOLN; BERGER RICHARD; SHIRAKAWA SEIJI; NOTTE GREGORY T 权利人:LEIGHTON JAMES LINCOLN; BERGER RICHARD; SHIRAKAWA SEIJI; NOTTE GREGORY T; TRUSTEE OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK 摘要:The present invention relates to a diastereomeric mixture of Silacycle Compounds and methods for using the diastereomeric mixture of Silacycle Compounds for stereoselective synthesis.
专利号:US-9395371-B2 优先权日:2010-09-24 标题:Synthesis of fluorescent noble metal nanoparticles 发明人:CHAN WARREN; PERRAULT STEVEN; CHOU LEO 权利人:CHAN WARREN; PERRAULT STEVEN; CHOU LEO 摘要:A process for the production of fluorescent nanoparticles selected from noble metal or silica nanoparticles. Noble metals or silica nanoparticles provide a platform to which fluorophores and other detection molecules can be added. The fluorescent nanoparticles can be used as regents, diagnostic assays and in the tracking or targeting of tumors.
专利号:US-3983120-A 优先权日:1974-11-06 标 题 :Process for the preparation of optionally substituted 1,2,3,5-tetrahydroimidazo[2,1-b]quinazolin-2-ones 发明人:BEVERUNG WARREN NEIL; PARTYKA RICHARD ANTHONY 权利人:BRISTOL MYERS CO 摘要:A new process has been developed for the synthesis of optionally substituted 1,2,3,5-tetrahydroimidazo[2,1-b]quinazolin-2-ones.
参考标题:Heterogeneously Catalyzed Direct Ch Thiolation Of Heteroarenes 作者:Suhelen Vásquez-Céspedes,Angélique Ferry,Lisa Candish,Frank Glorius |发布日期:2015.5.4 摘要:The First General Methodology For The Direct Thiolation Of Electron‐rich Heteroarenes Was Developed By Employing Pd/al2O3, A Recoverable And Commercially Available Heterogeneous Catalyst, And Cucl2. This Method Represents An Operationally Simple Approach For The Synthesis Of These Valuable Compounds. Preliminary Mechanistic Studies Indicate A Heterogeneous Catalytic System, In Which Both Metals Play
合成参考文献
摘要:Schatz, J.; Seler, M., Science of Synthesis Knowledge Updates, (2011) 2, 409. 摘要:Schatz, J.; Seler, M., Science of Synthesis Knowledge Updates, (2011) 2, 382. 摘要:Schatz, J.; Seler, M., Science of Synthesis Knowledge Updates, (2011) 2, 381. 摘要:Schatz, J.; Seler, M., Science of Synthesis Knowledge Updates, (2011) 2, 396. 摘要:Ipaktschi, J.; Saidi, M. R., Science of Synthesis Knowledge Updates, (2012) 4, 410.