CAS: 2013-26-5; Sodium 2-Oxobutanoate

相似化合物

68-04-2 6132-05-4 600-18-0

上下游产品

CAS号5094-24-6 丁卡因碱

1-Carbopropane-1,2,2-Tricarboxylic Acid Triethyl Ester 在 盐酸,Sodium Hydroxide体系中,用 水,甲醇作为反应溶剂,反应 8.0H,以92%的收率获得sodium 2-Oxobutyrate
参考文献:一种制备2-丁酮酸钠盐的工艺方法
标题:一种制备2-丁酮酸钠盐的工艺方法
摘要:本发明公开了一种制备2‑丁酮酸钠盐的工艺方法,包括以下步骤:S1:以甲基丙二酸二乙酯或甲基丙二酸二甲酯为原料,与草酸二乙酯或草酸二甲酯在适量碱性化合物催化下反应得到1‑羰基丙烷‑1,2,2‑三羧酸酯中间体;S2:将所述s1中得到的1‑羰基丙烷‑1,2,2‑三羧酸酯中间体与水在适量酸性化合物催化下反应得到2‑丁酮酸;S3:将步骤s2中得到的2‑丁酮酸与碱性化合物反应得到2‑丁酮酸钠盐.其路线设计合理,安全可靠,成本较低,能够量化生产.

专利信息

专利号:US-6133018-A
优先权日:1997-06-02
标 题 :Enzymatic synthesis of chiral amines using -2-amino propane as amine donor
发明人：WU WEI; BHATIA MOHIT B; LEWIS CRAIG M; LANG WEI; WANG ALICE L; MATCHAM GEORGE W
权利人:CELGRO
摘要:2-Aminopropane is used as the amine donor in the stereoselective synthesis of a chiral amine from a ketone with a transaminase. In a typical embodiment, (S)-1-methoxy-2-aminopropane is prepared by bringing methoxyacetone into contact with a transaminase in the presence of 2-aminopropane as an amine donor until a substantial amount of methoxyacetone is converted to (S)-1-methoxy-2-aminopropane and 2-aminopropane is converted to acetone. In a second embodiment, L-alanine is prepared by bringing pyruvic acid into contact with a transaminase in the presence of 2-aminopropane as an amine donor.

专利号:EP-1075534-B8
优先权日:1998-03-11
标 题 :Improvements in the enzymatic synthesis of chiral amines
发明人：WU WEI; BHATIA MOHIT B; LEWIS CRAIG M; LANG WEI; WANG ALICE; MATCHAM GEORGE W
权利人:CELGRO
摘要:2-Aminopropane is used as the amine donor in the stereoselective synthesis of a chiral amine from a ketone with a transaminase. In a typical embodiment, (S)-1-methoxy-2-aminopropane is prepared by bringing methoxyacetone into contact with a transaminase in the presence of 2-aminopropane as an amine donor until a substantial amount of methoxyacetone is converted to (S)-1-methoxy-2-aminopropane and 2-aminopropane is converted to acetone. In a second embodiment, L-alanine is prepared by bringing pyruvic acid into contact with a transaminase in the presence of 2-aminopropane as an amine donor.

专利号:US-4079180-A
优先权日:1975-01-22
标题 :Process for preparing 7-aminocephalosporanic acid derivatives
发明人：SUZUKI NOBUYUKI; SOWA TSUNEO; MURAKAMI MASAHIRO
权利人:ASAHI CHEMICAL IND
摘要:7-Aminocephalosporanic acid derivatives represented by the general formula (III), (III) wherein X is hydrogen, hydroxyl, acetate or a nucleophilic residue, which are useful as a starting material for the synthesis of cephalosporin type antibiotics low in toxicity and broad in pharmacological effect can be easily prepared by allowing to react cephalosporin C or its derivative represented by the general formula (I), (I) wherein X is as defined above, or a salt thereof with an alpha -keto derivative represented by the general formula (II), (II) wherein R1 is carboxyl, aroyl or amide when R2 is hydrogen, and is carboxyl when R2 is alkyl or aryl, or its salt. In this case, the yield of the 7-aminocephalosporanic acid derivatives can be remarkably improved by carrying out the reaction in the presence of hydrogen peroxide. The yield can be further improved by adding thiosulfuric acid or a salt thereof after the completion of the reaction to decompose the unreacted hydrogen peroxide.

专利号:WO-9946398-A1
优先权日:1998-03-11
标题:Improvements in the enzymatic synthesis of chiral amines

专利号:US-7122578-B2
优先权日:2001-09-11
标 题:Method and composition for treating mammalian diseases and injuries which cause pain, erythema, swelling, crusting, ischemia scarring and excess white blood cell infiltration
发明人：MARTIN ALAIN
权利人:MARTIN ALAIN
摘要:A method for treating the disease state in mammals caused by mammalian cells involved in the inflammatory response is disclosed. Mammalian cells participating in the inflammatory response are contacted with an inflammatory suppressor selected from the group consisting of alpha-keto acids and their salts which reduce the undesired inflammatory response and is an antioxidant. The inflammatory suppressor may further provide a cellular energy source and be a building block in the cellular synthesis of other cellular components. Compositions for reducing and treating undesired inflammatory response such as pain, swelling, erythema, crusting, scarring, itching, also disclosed.

专利号:EP-1075534-A4
优先权日:1998-03-11
标 题 :IMPROVEMENT OF THE ENZYMATIC SYNTHESIS OF CHIRAL AMINES