CAS: 20893-30-5; 2-(Thiophen-2-yl)Acetonitrile

相似化合物

1918-77-0 4461-29-4 872-55-9

上下游产品

CAS号765-50-4 2-氯甲基噻吩 | CAS号143-33-9 氰化钠 | CAS号139109-61-8 2-hydroxyimino-... | CAS号4461-29-4 噻酚-2-乙酰胺 | CAS号81745-84-8 chlorozinc(1+),... | CAS号590-17-0 溴乙腈 | CAS号151-50-8 氰化钾 | CAS号30807-46-6 2-(2-nitroethyl... | CAS号15022-15-8 噻吩-2-乙醛 | CAS号107112-93-6 6,7-Dihydrothie... | CAS号39098-97-0 2-噻吩乙酰氯 | CAS号144061-57-4 6-methoxy-3-met... | CAS号4461-29-4 噻酚-2-乙酰胺 | CAS号30433-78-4 4-甲基噻吩并[3,2-c]吡啶 | CAS号81820-65-7 2-(苯并[b]噻吩-4-基)吡啶 | CAS号1918-77-0 2-噻吩乙酸 | CAS号71637-32-6 3-羟基-2-(2-噻吩)丙烯腈 | CAS号57382-97-5 2-噻吩乙酸乙酯 | CAS号100058-72-8 1-(Thiophen-2-y...

2-噻吩乙酸置于光气,氯化亚砜,氨体系中,用 四氢呋喃,水,甲苯 用作溶剂,化学反应 5.0H,反应生成2-噻吩乙腈
参考文献:从相应的酰胺或腈合成 1-芳基-2-氨基链烷醇衍生物的一锅法
标题:从相应的酰胺或腈合成 1-芳基-2-氨基链烷醇衍生物的一锅法
摘要:我们已经确定了一种用于合成 β-氨基醇的新型一锅法,该方法基于苄基 α-碳原子上的 C-H 键羟基化,随后腈或酰胺官能团还原.这种级联过程使用分子氧作为氧化剂和双(2-甲氧基乙氧基)氢化铝钠作为还原剂.对 30 个条目检查了底物范围,尽管相应产品仅以中等产率提供,但上述简单方案可作为其他难以制备的空间拥挤 1,2-氨基醇的直接且有力的入口路线.给出了观察结果的合理机械原理,并将反应应用于潜在生物活性靶标的合成.
Doi:10.1039/d0Ra04359A

专利信息

专利号:EP-0439404-B1
优先权日:1990-01-25
标题 :Preparation of 2-(2'-thienyl) alkylamines and derivatives thereof and synthesis of 4,5,6,7- thieno [3,2-c] pyridine derivatives therefrom
发明人：KHATRI HIRALAL N; DEHOFF BRADLEY S
权利人:SANOFI SA
摘要:An improved process for the synthesis of 2-(2 min -thienyl)ethylamine from suitably functionalized derivatives of 2-(2 min -thienyl)ethanol employing ammonia gas in the presence of a metal salt or liquid ammonia and alkyl ketone as a solvent. The 2-(2 min -thienyl)ethylamine produced by this process is advantageously converted to the carbamic acid salt, which is suitably reconverted to 2-(2 min -thienyl)ethylamine, a useful intermediate in the synthesis of ticlopidine.

专利号:US-5068360-A
优先权日:1990-01-25
标题 :Preparation of 2-(2'-thienyl)ethylamine derivatives and synthesis of thieno(3,2-C)pyridine derivatives therefrom
发明人：DEHOFF BRADLEY S
权利人:SYNTEX INC
摘要:An improved process for the synthesis of 2-(2'-thienyl)ethylamine from suitably functionalized derivatives of 2-(2'-thienyl)ethanol employing ammonia gas in the presence of a metal salt or liquid ammonia and alkyl ketone as a solvent. The 2-(2'-thienyl)ethylamine produced by this process is advantageously converted to ticlopidine.

专利号:US-5191090-A
优先权日:1990-01-25
标题:Preparation of 2-(2'-thienyl)ethylamine derivatives and synthesis of thieno[3,2-c]pyridine derivatives therefrom
发明人：DEHOFF BRADLEY S
权利人:SYNTEX INC
摘要:An improved process for the synthesis of 2-(2'-thienyl)ethylamine from suitably functionalized derivatives of 2-(2'-thienyl)ethanol employing ammonia gas in the presence of a metal salt or liquid ammonia and alkyl ketone as a solvent. The 2-(2'-thienyl)ethylamine produced by this process is advantageously converted to ticlopidine.

专利号:US-6107495-A
优先权日:1996-07-24
标题:Thienylcyclohexane derivatives for thienylcyclohexyl synthesis
发明人：CAZAUX JEAN-BERNARD; DAFNIET MICHEL; KAMENKA JEAN-MARC; MANGINOT ERIC
权利人:EXPANSIA SA
摘要:PCT No. PCT/FR97/01382 Sec. 371 Date Jan. 19, 1999 Sec. 102(e) Date Jan. 19, 1999 PCT Filed Jul. 24, 1997 PCT Pub. No. WO98/03498 PCT Pub. Date Jan. 29, 1998Novel thienylcyclohexane derivatives of general formula (I), wherein R' is the 2-thienyl or 3-thienyl radical, R is the cyano radical or a radical of formula -C(O)A, and R2'' is a saturated or unsaturated optionally cyclic hydrocarbon radical, or an aryl radical, are disclosed. Methods for preparing said compounds, and the use thereof as novel industrial products for the synthesis of thienylcyclohexyl derivatives, are also disclosed.

专利号:US-5516910-A
优先权日:1991-01-31
标题:N--2--chlorobenzyl--2--oxo and n--2--chlorobenzyl--2,2--dioxo--1,2,3--oxathiazolidine derivatives, their preparation and synthesis of thieno[3,2--c]pyridine derivatives therefrom
发明人：COOPER GARY F; MCCARTHY KEITH E
权利人:SYNTEX INC
摘要:Compounds of the formula: ##STR1## wherein: A is oxo or dioxo; n R 1 , R 2 and R 3 are independently hydrogen or lower alkyl of one to six carbon atoms; n R 4 , R 5 , R 6 and R 7 are independently hydrogen, lower alkyl of one to six carbon atoms, alkoxy, acyl or halo; n are advantageously converted to thieno[3,2-c]pyridine derivatives and the pharmaceutically acceptable salts thereof, particularly ticlopidine hydrochloride.

专利号:EP-0522956-B1
优先权日:1991-07-08
标 题 :Preparation of 2-(2-thienyl) ethylamine and synthesis of thieno [3,2-C] pyridine derivatives therefrom
发明人：HARRINGTON PETER J; SANCHEZ IGNACIO H
权利人:SANOFI SA
摘要:Compounds of the formulae: and wherein: R<1>, R<2>, R<3> and R<4> are independently hydrogen, lower alkyl of one to six carbon atoms, aryl or substituted aryl; are advantageously converted to isocyanurate compounds, 2-(2-thienyl)ethylamine compounds and thieno[3,2-c]pyridine derivatives and the pharmaceutically acceptable salts thereof, particularly ticlopidine hydrochloride.