CAS: 27469-60-9; 4,4-Difluorobenzhydrylpiperazine

上下游产品

CAS号110-85-0 哌嗪 | CAS号27064-94-4 双(4-氟苯基)氯甲烷 | CAS号365-24-2 4,4'-二氟二苯甲醇 | CAS号345-92-6 4,4'-二氟二苯甲酮 | CAS号142-64-3 哌嗪二盐酸盐单水合物 | CAS号345-90-4 双(4-氟苯基)溴甲烷 | CAS号104690-91-7 1-[bis(4-fluoro... | CAS号143759-79-9 1-benzylsulfany... | CAS号52468-60-7 氟桂利嗪 | CAS号27469-53-0 阿米君 | CAS号101477-47-8 1-[bis(4-fluoro... | CAS号101477-54-7 盐酸洛美利嗪

4,4'-二氟二苯甲醇置于哌啶,氯化亚砜体系中,用 二氯甲烷,环己烷 用作溶剂,化学反应 20.0H,反应生成4,4'-二氟苯甲哌嗪
参考文献:芳氧基乙酰胺衍生物作为神经保护剂的合成及生物学评价.
标题:芳氧基乙酰胺衍生物作为神经保护剂的合成及生物学评价.
摘要:设计并合成了一系列新的芳氧基乙酰胺衍生物10A-S和14A-M.在分化的大鼠嗜铬细胞瘤细胞(pc12细胞)中研究了它们对谷氨酸诱导的细胞死亡的保护活性.大多数化合物表现出神经保护作用,尤其是对10M,10R,14B和14C表现出神经保护作用,在三种剂量(0.1,1.0,10μm)下,Pc12细胞都有潜在的保护作用.Mtt分析,Hoechst 33342 / Pi双重染色和高含量筛选(hcs)显示,用10M,10R,14B和14C预处理细胞以剂量依赖的方式显着降低了细胞凋亡的程度.蛋白质印迹分析的结果表明,这些化合物通过caspase-3途径抑制了谷氨酸诱导的pc12细胞凋亡.这些化合物可以是用于进一步发现用于治疗脑缺血性中风的神经保护剂的先导化合物.还介绍了基本的结构-活性关系.
Doi:10.1016/j.Bmcl.2016.03.094

专利信息

专利号:US-2005019747-A1
优先权日:2002-08-07
标 题 :Nanoliter-scale synthesis of arrayed biomaterials and screening thereof
发明人：ANDERSON DANIEL G; LEVENBERG SHULAMIT; LANGER ROBERT S
摘要:A method of screening cell-polymer interactions. The method includes depositing monomers as a plurality of discrete elements on a substrate, causing the deposited monomers to polymerize, thereby creating an array of discrete polymer elements on the substrate, incubating the substrate in a cell-containing culture medium, and characterizing a predetermined cell behavior on each polymer element.

专利号:US-7511141-B2
优先权日:2001-03-02
标题 :Piperidine-piperazine ligands for neurotransmitter receptors
发明人：PERSONS PAUL E; RADEKE HEIKE
权利人:SEPRACOR INC
摘要:One aspect of the present invention relates to piperidine-piperazine compounds. A second aspect of the present invention relates to the use of the piperidine-piperazine compounds as ligands for various mammalian cellular receptors or transporters or both, including dopamine, serotonin or norepinephrine receptors or transporters, any combination of them, or all of them. The compounds of the present invention will find use in the treatment of numerous ailments, conditions and diseases which afflict mammals, including but not limited to addiction, anxiety, depression, sexual dysfunction, hypertension, migraine, Alzheimer's disease, obesity, emesis, psychosis, analgesia, schizophrenia, Parkinson's disease, restless leg syndrome, sleeping disorders, attention deficit hyperactivity disorder, irritable bowel syndrome, premature ejaculation, menstrual dysphoria syndrome, urinary incontinence, inflammatory pain, neuropathic pain, Lesche-Nyhane disease, Wilson's disease, and Tourette's syndrome. An additional aspect of the present invention relates to the synthesis of combinatorial libraries of the piperidine-piperazine compounds, and the screening of those libraries for biological activity, e.g., in assays based on dopamine receptors or transporters or both.

专利号:CA-2539670-A1
优先权日:2003-09-15
标 题:Nanoliter-scale synthesis of arrayed biomaterials and screening thereof

专利号:US-6417195-B1
优先权日:1999-02-22
标题 :Isoquinoline derivatives and isoquinoline combinatorial libraries
发明人：LEBL MICHAL
权利人:LION BIOSCIENCE AG
摘要:The present invention provides the synthesis of heterocyclic compounds based on the isoquinoline ring. More specifically, the invention provides novel isoquinoline derivatives as well as novel libraries comprised of such compounds.

专利号:WO-2005028619-A2
优先权日:2003-09-15
标题:Nanoliter-scale synthesis of arrayed biomaterials and screening thereof

专利号:EP-1675943-A4
优先权日:2003-09-15
标 题 :SYNTHESIS OF BIOMATERIALS ARRANGED IN AN ARRAY IN THE NANOLITE ASSEMBLY AND SCREENING THEREOF