CAS: 330628-04-1; (2R,3S,5R)-2-((Bis(4-Methoxyphenyl)(Phenyl)Methoxy)Methyl)-5-(2-(((Dimethylamino)Methylene)Amino)-6-Oxo-3H-Purin-9(6H)-yl)Tetrahydrofuran-3-Yl (2-Cyanoethyl) Diisopropylphosphoramidite

该化合物是一种受保护的脱氧guanosine衍生物,用于固态阶段的寡核糖核酸合成. 甲氧三丁基(DMT)组确保链长期间有选择性的去保护,而dmf(N,N-二甲基二甲基二甲基丙胺)保护组则稳定了guanine的外环环矿,防止侧面反应. 这种磷米地显示与标准的自动合成程序具有高度的结合效率和兼容性,确保可靠地融入DNA序列. 它在无水条件下的稳定性和精确的再活动使得它适合于生产高纯性寡氧核酸酸,用于研究,诊断和治疗应用.建议在惰性大气下进行适当处理以保持完整性.

英文名称(2R,3S,5R)-2-((Bis(4-Methoxyphenyl)(Phenyl)Methoxy)Methyl)-5-(2-(((Dimethylamino)Methylene)Amino)-6-Oxo-3H-Purin-9(6H)-yl)Tetrahydrofuran-3-Yl (2-Cyanoethyl) Diisopropylphosphoramidite
中文名称DMF-DG-CE亚磷酰胺单体
IUPAC名称(2R,3S,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(2-(((E)-(dimethylamino)methylene)amino)-6-oxo-3,6-dihydro-9H-purin-9-yl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite
其它别名N4-(Dimethylamino)Methylene)-5'-O-(Dimethoxytrityl)-2'-Deoxyguanosine-3'-N,N-Diisopropyl (Cyanoethyl) Phosphoramidite; Dmt-Dg(Dmf) Amidite; N2-(Dimethylamino)Methylene-Deoxyguanosine Phosphoramidite; (2R,3S,5R)-2-((Bis(4-Methoxyphenyl)(Phenyl)Methoxy)Methyl)-5-(2-((E)-(Dimethylamino)Methyleneamino)-6-Oxo-1H-Purin-9(6H)-yl)Tetrahydrofuran-3-Yl 2-Cyanoethyl Diisopropylphosphoramidite; Ref Dupl: Dmf-Dg-Ce-Phophoramidite; N4-(Dimethylamino) Methylene)-5'-O-(Dimethoxytrityl)-2'-Deoxyguanosine-3'-N,N-Diisopropyl(Cyanoethyl) Phosphoramidite; 2'-Deoxy-N2-Dmf-5'-O-Dmt-Guanosine 3'-Ce Phosphoramidite; Dmf-Dg-Ce Phosphoramidite
CAS编号330628-04-1
MFCD编号:MFCD00797420
分子式:C43H53N8O7P
分子量:824.9
产品CID: 1323958
产品分类有机原料→官能团→氰化物/腈

相似结构搜索
InChIKey: YRQAXTCBMPFGAN-UNHDIWNRSA-N
InChI=1S/C43H53N8O7P/c1-29(2)51(30(3)4)59(56-24-12-23-44)58-36-25-38(50-28-45-39-40(50)47-42(48-41(39)52)46-27-49(5)6)57-37(36)26-55-43(31-1…
计算化学: 氢键受体数13.0氢键供体数1.0可旋转键数19.0

相似化合物

141684-35-7 93183-15-4 149559-87-5

MSDS等安全信息

GHS符号GHS07
警示词Warning
危险描述H302-H315-H319-H335
防范说明P261-P280-P302+P352
UN编号NONH for all modes of transport
危险品标志Xi
安全声明24/25
WGK Germany3

上下游产品

5'-O-[bis(4-methoxyphenyl)phenylmethyl]-8-bromo-2'-deoxy-N-[(dimethylamino)methylene]guanosine N,N,N',N'-tetraisopropyl 2-cyanoethylphosphorodiamidite 4,4'-dimethoxytrityl chloride 2-dimethylaminomethylene-2'-deoxyguanosineN2-dimethylaminomethylene-2'-deoxyguanosine