CAS: 340-90-9; (S)-2-(1,3-Dioxoisoindolin-2-yl)Pentanedioic Acid

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CAS号1004761-79-8 diethyl (1-chlo... | CAS号56-86-0 L-谷氨酸 | CAS号85-44-9 苯酐 | CAS号22509-74-6 N-乙氧羰基邻苯二甲酰亚胺 | CAS号112710-87-9 Nγ,Nγ-diethyl-N... | CAS号25830-77-7 N-邻苯二甲酰-L-谷氨酸酐 | CAS号88-95-9 邻苯二甲酰氯 | CAS号112655-44-4 diethyl N,N-pht... | CAS号16450-41-2 谷氨酸二乙酯 | CAS号50-35-1 沙利度胺 | CAS号3130-75-4 4-苯二甲酰亚氨基丁酸 | CAS号3081-61-6 L-茶氨酸 | CAS号25830-77-7 N-邻苯二甲酰-L-谷氨酸酐 | CAS号2614-06-4 (R)-(+)-沙利度胺 | CAS号39739-04-3 dimethyl 2-(1,3...

Diethyl N,N-Phtaloyl-L-Glutamic Acid置于盐酸,水,溶剂黄146体系中,化学反应生成 Pht-谷氨酸
参考文献:N,N-Phthaloyl-L-Glutamic Acid And Some Derivatives
标题:N,N-Phthaloyl-L-Glutamic Acid And Some Derivatives
摘要:
DOI:10.1021/jo01118A004

专利信息

专利号:US-8193156-B1
优先权日:2006-05-18
标 题:Dipeptides incorporating selenoamino acids with enhanced bioavailability—synthesis, pharmaceutical and cosmeceutical applications thereof
发明人：MAJEED MUHAMMED; NAGABHUSHANAM KALYANAM; RAMANUJAM RAJENDRAN; CHANDRAMOULI RENUKESHWAR H
权利人:MAJEED MUHAMMED; NAGABHUSHANAM KALYANAM; RAMANUJAM RAJENDRAN; CHANDRAMOULI RENUKESHWAR H; SAMI LABS LTD
摘要:Disclosed is a novel synthetic method for isomeric peptides through an appropriate linkage of L-selenomethionine or Se-Methyl-L-selenocysteine with L-glutamic acid. The novel synthetic method produces isomeric peptides of L-selenomethionine or Se-Methyl-L-selenocysteine that exhibit (i) enhanced water solubility; (ii) enhanced rate of dissolution in water; (iii) enhanced bioavailability; (iv) excellent vascular endothelial growth factor promoting activity; (v) excellent anti-5-alpha-reductase activity; (vi) capabilities to prevent/reduce “hair fall†and promote “hair growth†, thereby maintaining a perfect homeostasis for “hair care†. Cosmeceutical and pharmaceutical compositions comprising the isomeric peptides obtained through an appropriate linkage of L-selenomethionine or Se-Methyl-L-selenocysteine with L-glutamic acid are also disclosed. Other dipeptides with several other amino acids and uses thereof are also disclosed.

专利号:WO-9729091-A1
优先权日:1996-02-09
标题:Balanol analogues
发明人：NIELSEN JOHN; LYNGSOE LARS OLE
权利人:AUDA PHARMACEUTICALS APS; NIELSEN JOHN; LYNGSOE LARS OLE
摘要:The present invention relates to a solid phase methodology for the preparation of a combinatorial library of structural analogues of the natural product balanol (ophiocordin, azepinostatin), which is a protein kinase C (PKC) and protein kinase A (PKA) inhibitor. The method comprises solid-phase synthesis of the analog variants of balanol whereby a high molecular diversity is introduced. The synthetic scheme is based on a retrosynthetic analysis of the native structure which revealed three main building blocks suitable as templates for modification. The dicarboxy-functional moiety can be immobilised to the polymer support either as the monoallyl ester or as the internal anhydride. The libraries produced by the method are especially suited for high throughput screening of potential drug candidates for the treatment of mammals, especially humans.

专利号:EP-1280780-A2
优先权日:2000-05-04
标 题:Asymmetric synthesis of piperazic acid and derivatives thereof

专利号:WO-0183458-A2
优先权日:2000-05-04
标 题:Asymmetric synthesis of piperazic acid and derivatives thereof

专利号:WO-9710263-A1
优先权日:1995-09-12
标 题 :Actinomycin d analogues
发明人：TONG GLENN; NIELSEN JOHN
权利人:AUDA PHARMACEUTICALS APS; TONG GLENN; NIELSEN JOHN
摘要:The present invention relates to new compounds being structurally and functionally similar to Actinomycin D and to combinatorial libraries of such compounds. The Actinomycin D analogues according to the present invention comprise two linear or cyclic peptide moieties constituted by α-amino acids, β-amino acids and/or longer chain φ-amino acids, and a difunctional group which preferably is a cyclic entity, in particular, an aromatic or heteroaromatic entity acting as an intercalator group. Specific compounds and a library of such compounds may be prepared using conventional solid phase peptide synthesis (SPPS) methodologies. The novel compounds are expected to have affinity for DNA and RNA, and libraries thereof may therefore advantageously be used for screening purposes. Furthermore, a novel double-combinatorial technique that may be used in the preparation of librairies of broader classes of compounds has been developed.

专利号:CN-114890988-A
优先权日:2022-04-28
标 题 :Chemical synthesis method of thalidomide