CAS: 3842-86-2; Diethyl (2-(Dimethylamino)-2-Oxoethyl)Phosphonate

相似化合物

5464-68-6 124931-12-0 1067-74-9

亚磷酸三乙酯,2-氯-N,N-二甲基乙酰胺 反应 5.5H,以78%的收率获得(2-(二甲基氨基)-2-氧代乙基)膦酸二乙酯
参考文献:β,β-二取代 α,β-不饱和酰胺的去质子化-机理和立体化学结果
标题:β,β-二取代 α,β-不饱和酰胺的去质子化-机理和立体化学结果
摘要:详细研究了二烷基酰胺锂诱导 β,β-二取代 α,β-不饱和酰胺去质子化.γ-Z 碳原子上取代基的优先 γ-Z-去质子化和立体化学结果在循环八元过渡态方面被合理化,这得到了 Dft 计算的支持.亚环己基甲酰胺的类似去质子化揭示了对八元环状过渡态的偏好与环上现有取代基的影响和扭船过渡态的干预之间的微妙平衡. 关键词:二烯醇,酰胺,去质子化机制,过渡状态,烯醇化,区域选择性,立体选择性.
Doi:10.1139/v06-112

专利信息

专利号:US-4564477-A
优先权日:1982-02-19
标题 :Polyprenyl compounds and method of producing the same
发明人：TAKIGAWA TETSUO; IBATA KOICHI; OKADA MASAFUMI; MIZUNO MASAO; NISHIDA TAKASHI
权利人:KURARAY CO
摘要:There are provided polyprenyl compounds of the formula ##STR1## wherein ##STR2## represent a trans-isoprene unit and a cis-isoprene unit, respectively, n is an integer of 11-19, Z 1 and Z 2 combinedly represent â•?O, â•?CH--COOH,â•?CH--COOR 1 , â•?CH--CN, â•?C(CN)COOR 2 , â•?CH--CO--NH 2 , â•?CH--CO--N(R 3 ) (R 4 ), â•?CH--CO--NHR 5 , â•?CH--CH 2 --N(R 3 ) (R 4 ), â•?CH--CH 2 --NHR 5 or â•?CH--CHO or Z 1 is a hydrogen atom and Z 2 is --CH 2 COOH, --CH 2 COOR 6 , --CH(CN)COOR 2 , --CH 2 CN, --CH 2 --CO--NH 2 , --CHâ•?CH--N(R 3 ) (R 4 ) or --CH 2 --CHâ•?N--R 5 , R 1 , R 2 and R 6 each being a lower alkyl group, R 3 and R 4 each independently being a lower-alkyl, cycloalkyl, aryl or aralkyl group or R 3 and R 4 combinedly representing an alkylene group containing 2-5 carbon atoms, and R 5 being a lower-alkyl, cycloalkyl, aryl or aralkyl group. These polyprenyl compounds can be synthesized starting with a polyprenol obtainable from leaves of a plant such as Ginkgo biloba or Cedrus deodara by extraction and as necessary followed by hydrolysis, or a reactive derivative thereof. The polyprenyl compounds are useful as intermediates for the synthesis of dolichol without the ue of an expensive C 5 chain extender.