CAS: 39978-14-8; Methyl 4-Aminothiophene-3-Carboxylate Hydrochloride

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CAS号2689-68-1 4-氧四氢噻酚-3-羧酸甲酯 | CAS号58230-46-9 4-hydroxyimino-... | CAS号69363-85-5 4-氨基噻吩-3-羧酸甲酯 | CAS号108180-63-8 4-叔丁氧羰基氨基-3-噻吩甲酸 | CAS号161940-20-1 4-((叔丁氧羰基)氨基)噻吩... | CAS号53826-78-1 4-甲酰基氨基噻吩-3-羧酸甲酯

4-氧四氢噻酚-3-羧酸甲酯置于盐酸,盐酸羟胺,Barium Carbonate体系中,用 甲醇,乙醚,水 用作溶剂,化学反应 36.0H,反应生成3-氨基噻吩-4-羧酸甲酯盐酸盐
参考文献:天然产物evodiamine启发的脚手架多样性:高强度和多靶点抗肿瘤药物的发现
标题:天然产物evodiamine启发的脚手架多样性:高强度和多靶点抗肿瘤药物的发现
摘要:基于天然产物的药物发现中的一个关键问题是如何将产物转化为具有最佳药理特性的类药物分子.天然产物启发的支架多样性的产生是一种有效但具有挑战性的策略,用于研究更广阔的化学空间并确定有前途的药物线索.将我们的工作扩展到天然产物evodiamine,设计并合成了一个包含11个evodiamine启发的新型支架及其衍生物的多样化文库.它们中的大多数显示出对各种人类癌细胞系的非常好至优异的抗肿瘤活性.特别地,3-氯-10-羟基硫代吴茱萸碱(66C)显示出优异的体外和体内抗肿瘤功效,耐受性好,毒性低.抗肿瘤机制和靶标分析研究表明,化合物66C是同类中的第一个三重拓扑异构酶i /拓扑异构酶ii /微管蛋白抑制剂.总的来说,这项研究为基于天然产物的药物发现提供了有效的策略.
Doi:10.1021/acs.Jmedchem.5B00910

专利信息

专利号:US-4670560-A
优先权日:1986-04-28
标 题:Thienopyrimidine-2,4-dione derivatives and intermediates thereof
发明人：PRESS JEFFERY B; RUSSELL RONALD K
权利人:ORTHO PHARMA CORP
摘要:The synthesis of thienopyrimidine-2,4-dione derivatives and their urea intermediates is described. The novel urea intermediates and thienopyrimidine-2,4-dione derivatives are generally vasodilating agents and anti-hypertensive agents. The compounds are useful as cardiovascular agents.

专利号:US-4707550-A
优先权日:1986-04-28
标题 :N-(substituted thienyl)-N'-(substituted piperazinyl)-ureas
发明人：PRESS JEFFERY B; RUSSELL RONALD K
权利人:ORTHO PHARMA CORP
摘要:The synthesis of thienopyrimidine-2,4-dione derivatives and their urea intermediates is described. The novel urea intermediates and thienopyrimidine-2,4-dione derivatives are general vasodilating agents and anti-hypertensive agents. The compounds are useful as cardiovascular agents.

专利号:US-4939137-A
优先权日:1989-06-28
标 题:Ring-fused thienopyrimidinedione derivatives
发明人：RUSSELL RONALD K; RAMPULLA RICHARD A
权利人:ORTHO PHARMA CORP
摘要:The synthesis of ring-fused thienopyrimidinedione derivatives is described. The novel ring-fused thienopyrimidinedione derivatives are generally vasodilating agents and antihypertensive agents and as such are useful as cardiovascular agents.