专利号:US-12383499-B2 优先权日:2018-01-01 标题:Scale up synthesis of silicasome nanocarriers 发明人:NEL ANDRE E; MENG HUAN; LIU XIANGSHENG 权利人:UNIV CALIFORNIA 摘要:In order to facilitate the approval and commercialization of silicasome drug delivery systems (e.g. irinotecan silicasomes) it is necessary to scale up synthesis of the drug-loaded silicasomes. In this regard, it was discovered that the synthesis protocols used for laboratory synthesis of drug-loaded silicasomes (e.g., 500 mg/batch) do not scale to large scale silicasome production, because the resulting products were too heterogeneous for use as pharmaceuticals. Accordingly, new methods are provided herein that effectively afford the large-scale production of mesoporous silica nanoparticles (MSNPs) and lipid bilayer coated MSNPs (silicasomes).
专利号:US-5110929-A 优先权日:1986-08-07 标题 :Process for the preparation of N-alkylated quaternary nitrogen containing aromatic heterocycles 发明人:PARADIES HENRICH H 权利人:MEDICE CHAM PHARM FABRIK PUTTE 摘要:The synthesis of 4-, 4-(1,1)-and 3,5-substituted N-alkyl-pyridinium salts as well as of 2-carboxamide substituted N(1,4)diazinium compounds are described. The N-surfactants obtained have a small critical micelle concentration (CMC) of 10-5 -10-7 Mol/Liter. These surfactants produce micells of different size and form depending on the nature of the anions. 4-(1,1)-substituted and 3,5-substituted N-alkyl-pyridinium components are capable of forming vesicles in equeous solutions of different forms and sizes. The N-surfactants synthesized can be used as pharmaceuticals.
专利号:WO-2014047807-A1 优先权日:2012-09-26 标 题 :Sapo-44 molecular sieves and synthesis method thereof 发明人:TIAN PENG; FAN DONG; LIU ZHONGMIN; SU XIONG; ZHANG YING; YANG YUE 权利人:DALIAN CHEMICAL PHYSICS INST 摘要:The present invention relates to SAPO-44 molecular sieves and to a synthesis method thereof. The invention is characterized in that the micropores of the molecular sieves contain a hexamethyleneimine template agent, the surface of the molecular sieve crystal body is slightly silicon-rich, and the ratio of external surface silicon contents to the bulk silicon contents of the crystal body is 1.50 to 1.01. Said molecular sieves, following calcination in air at 400〜700°C, can be used as a catalyst for acid-catalyzed reactions and oxygenate-to-olefin reactions.
专利号:US-2009054649-A1 优先权日:2005-09-22 标题 :Bridged Organosilane and Production Method Thereof 发明人:SHIMADA TOYOSHI; GOTO YASUTOMO; INAGAKI SHINJI; MIZOSHITA NORIHIRO; IKAI MASAMICHI 权利人:TOYOTA CHUO KENKYUSHO KK; TOYOSHI SHIMADA 摘要:Provided is a bridged organosilane, which has a large complex organic group, and which is useful in the synthesis of a mesoporous silica and a light-emitting material, and a production method of the bridged organosilane. The bridged organosilane is expressed by the following general formula (1): n n n n n n n n n n [in the formula (1), q represents an integer in a range from 2 to 4, X 1 — represents a substituent selected from the group consisting of substituents expressed by the following general formulae (2) to (5): n n n n n n n n n n (in the formulae (2) to (5), R 1 represents alkyl group having 1 to 5 carbon atoms, R 2 represents an allyl group, and n represents an integer in a range from 0 to 3, and m represents an integer in a range from 0 to 6), and A 1 represents an organic group expressed by, for example, the following general formula (6): n n n n n n n n n n (in the formula (6), Y 1 < represents a substituent expressed by, for example, Oâ•?<)].
专利号:EP-3567040-B1 优先权日:2013-06-24 标 题 :Method for the preparation of intermediates useful for the synthesis of [1,2,4]-triazolo[4,3-a]pyridines
专利号:US-2008214386-A1 优先权日:2004-03-01 标题:Catalyst for Cyclic Carbonate Synthesis 发明人:TAKAHASHI TOSHIKAZU; WATAHIKI TSUTOMU; YASUDA HIROYUKI; SAKAKURA TOSHIYASU 权利人:TAKAHASHI TOSHIKAZU; WATAHIKI TSUTOMU; YASUDA HIROYUKI; SAKAKURA TOSHIYASU 摘要:Provided are a solid catalyst which gives a cyclic carbonate at a high yield and a high selectivity, which is stable and which may be readily separated after reaction; and a method of industrially advantageous, inexpensive and safe production of a cyclic carbonate by the use of the catalyst. The catalyst contains an inorganic solid substance having a surface modified with an ionic substance containing a Group 15 element; or contains an ionic substance containing a Group 15 element, and an inorganic solid substance. The modifying group for surface modification of an inorganic solid substance is an ionic substance containing a Group 15 element. The ionic substance containing a Group 15 element is at least one substance selected from organic phosphonium salts, organic ammonium salts, organic arsonium salts and organic antimonium salts.
参考文献:10.1016/j.bmcl.2004.03.096|10.1016/s0960-894x(04)00470-6 摘要:Hill TA, Odell LR, Quan A, Abagyan R, Ferguson G, Robinson PJ, McCluskey A. Long chain amines and long chain ammonium salts as novel inhibitors of dynamin GTPase activity. Bioorganic & Medicinal Chemistry Letters. 2004 Jun;14(12):3275–8. doi: 10.1016/j.bmcl.2004.03.096.