合成目标产物 3-Bromo-5-Methoxypyridine 主要起始原料 3,5-Dibromopyridine And Methanol
(文献来源)合成步骤主要原料 3,5-Dibromopyridine 和 Methanol
2,5-二溴吡啶置于sodium Methylate,碳酸氢钠体系中,用 甲醇,乙酸乙酯 作为反应溶剂,化学反应生成 3-溴-5-甲氧基吡啶 参考文献:Substituted 4H-Chromenes And Analogs As Activators Of Caspases And Inducers Of Apoptosis And The Use Thereof 标题:Substituted 4H-Chromenes And Analogs As Activators Of Caspases And Inducers Of Apoptosis And The Use Thereof 摘要:本发明涉及被一般式i表示的取代的4H-香豆素及其类似物: 1 其中r 1-R 5,A,Y和z在此处被定义.本发明还涉及发现具有式i的化合物是caspase的激活剂和凋亡诱导剂.因此,本发明的caspase激活剂和凋亡诱导剂可用于诱导在各种临床病况中发生细胞死亡,其中异常细胞的不受控制的生长和传播.
专利号:CN-113321668-A 优先权日:2021-06-21 标题:Synthesis of Serpatinib
专利号:US-6017926-A 优先权日:1997-12-17 标题 :Integrin receptor antagonists 发明人:ASKEW BEN C; COLEMAN PAUL J; DUGGAN MARK E; HALCZENKO WASYL; HUTCHINSON JOHN H; MEISSNER ROBERT S; PATANE MICHAEL A; WANG JIABING 权利人:MERCK & CO INC 摘要:The present invention relates to compounds and derivatives thereof, their synthesis, and their use as integrin receptor antagonists. More particularly, the compounds of the present invention are antagonists of the integrin receptors alpha v beta 3, alpha v beta 5 and/or alpha v beta 6 and are useful for inhibiting bone resorption, treating and preventing osteoporosis, and inhibiting vascular restenosis, diabetic retinopathy, macular degeneration, angiogenesis, atherosclerosis, inflammation, wound healing, viral disease, and tumor growth and metastasis.
专利号:EP-1040111-B1 优先权日:1997-12-17 标 题:Integrin receptor antagonists 发明人:DUGGAN MARK E; MEISSNER ROBERT S; HUTCHINSON JOHN H; HALCZENKO WASYL; ASKEW BEN C; COLEMAN PAUL J; PATANE MICHAEL A; WANG JIABING; PERKINS JAMES J 权利人:MERCK & CO INC 摘要:The present invention relates to compounds and derivatives thereof, their synthesis, and their use as integrin receptor antagonists. More particularly, the compounds of the present invention are antagonists of the integrin receptors alpha v beta 3, alpha v beta 5 and/or alpha v beta 6 and are useful for inhibiting bone resorption, treating and preventing osteoporosis, and inhibiting vascular restenosis, diabetic retinopathy, macular degeneration, angiogenesis, atherosclerosis, inflammation, wound healing, viral disease, and tumor growth and metastasis.
专利号:US-6268378-B1 优先权日:1997-12-17 标题 :Integrin receptor antagonists 发明人:DUGGAN MARK E; MEISSNER ROBERT S; PERKINS JAMES J 权利人:MERCK & CO INC 摘要:The present invention relates to compounds and derivatives thereof, their synthesis, and their use as vitronectin receptor antagonists. More particularly, the compounds of the present invention are antagonists of the vitronectin receptors alphavbeta3 and/or alphavbeta5 and are useful for inhibiting bone resorption, treating and preventing osteoporosis, and inhibiting vascular restenosis, diabetic retinopathy, macular degeneration, angiogenesis, atherosclerosis, inflammation, viral disease, and tumor growth.
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