CAS: 513-49-5; (S)-(+)-2-Aminobutane

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CAS号78-93-3 甲乙酮 | CAS号108-05-4 乙酸乙烯酯 | CAS号33966-50-6 丁胺 | CAS号108-22-5 醋酸异丙烯酯 | CAS号141-78-6 乙酸乙酯 | CAS号13250-12-9 (R)-(-)-2-氨基丁烷 | CAS号37143-54-7 1-甲氧基-2-丙胺 | CAS号1149605-19-5 N-[(2S)-2-Butan...

丁酮置于glucose Dehydrogenase,L-丙氨酸,葡萄糖,ω-Transaminase Ata-113,磷酸吡哆醛,Nicotinamide Adenine Dinucleotide,L-Lactate Dehydrogenase体系中,化学反应 24.0H,反应生成 (S)-(+)-2-氨基丁烷
参考文献:使用ω-转氨酶的光学纯胺相关的不对称合成
标题:使用ω-转氨酶的光学纯胺相关的不对称合成
摘要:测试了各种ω-转氨酶,以d-或l-丙氨酸为氨基供体和乳酸脱氢酶从相应的酮合成对映体纯的胺,以除去副产物丙酮酸,从而将不利的反应平衡转移至产物侧.(R)-和(S)-胺这两种对映异构体均可以在50 Mm底物浓度下于24小时内以高达99%ee和> 99%的转化率制备.胺化反应的活性和立体选择性取决于所用的ω-转氨酶和底物.此外,助溶剂显着影响转氨酶的立体选择性和活性.通过使用ata-117获得(r对映体和ata-113或ata-103,以15%v V-1 Dmso进入(S)对映体.
DOI:10.1002/adsc.200800496

专利信息

专利号:US-6133018-A
优先权日:1997-06-02
标 题 :Enzymatic synthesis of chiral amines using -2-amino propane as amine donor
发明人：WU WEI; BHATIA MOHIT B; LEWIS CRAIG M; LANG WEI; WANG ALICE L; MATCHAM GEORGE W
权利人:CELGRO
摘要:2-Aminopropane is used as the amine donor in the stereoselective synthesis of a chiral amine from a ketone with a transaminase. In a typical embodiment, (S)-1-methoxy-2-aminopropane is prepared by bringing methoxyacetone into contact with a transaminase in the presence of 2-aminopropane as an amine donor until a substantial amount of methoxyacetone is converted to (S)-1-methoxy-2-aminopropane and 2-aminopropane is converted to acetone. In a second embodiment, L-alanine is prepared by bringing pyruvic acid into contact with a transaminase in the presence of 2-aminopropane as an amine donor.

专利号:EP-1075534-B8
优先权日:1998-03-11
标 题 :Improvements in the enzymatic synthesis of chiral amines
发明人：WU WEI; BHATIA MOHIT B; LEWIS CRAIG M; LANG WEI; WANG ALICE; MATCHAM GEORGE W
权利人:CELGRO
摘要:2-Aminopropane is used as the amine donor in the stereoselective synthesis of a chiral amine from a ketone with a transaminase. In a typical embodiment, (S)-1-methoxy-2-aminopropane is prepared by bringing methoxyacetone into contact with a transaminase in the presence of 2-aminopropane as an amine donor until a substantial amount of methoxyacetone is converted to (S)-1-methoxy-2-aminopropane and 2-aminopropane is converted to acetone. In a second embodiment, L-alanine is prepared by bringing pyruvic acid into contact with a transaminase in the presence of 2-aminopropane as an amine donor.

专利号:US-7109377-B2
优先权日:1996-10-16
标 题:Synthesis of combinatorial libraries of compounds reminiscent of natural products
发明人：SCHREIBER STUART L; SHAIR MATTHEW D; TAN DEREK S; FOLEY MICHAEL A; STOCKWELL BRENT R
权利人:HARVARD COLLEGE
摘要:The present invention provides complex compounds reminiscent of natural products and libraries thereof, as well as methods for their production. The inventive compounds and libraries of compounds are reminiscent of natural products in that they contain one or more stereocenters, and a high density and diversity of functionality. In general, the inventive libraries are synthesized from diversifiable scaffold structures, which are synthesized from readily available or easily synthesizable template structures. In certain embodiments, the inventive compounds and libraries are generated from diversifiable scaffolds synthesized from a shikimic acid based epoxyol template. In other embodiments, the inventive compounds and libraries are generated from diversifiable scaffolds synthesized from the pyridine-based template isonicotinamide. The present invention also provides a novel ortho-nitrobenzyl photolinker and a method for its synthesis. Furthermore, the present invention provides methods and kits for determining one or more biological activities of members of the inventive libraries. Additionally, the present invention provides pharmaceutical compositions containing one or more library members.

专利号:US-11717498-B2
优先权日:2013-12-31
标题 :Methods of treatment using amphetamine controlled release, prodrug, and abuse deterrent dosage forms
发明人：POPP KARL; MECKLER HAROLD
权利人:Chemapotheca LLC; PHARMAPOTHECA A INC
摘要:The invention also relates to pharmaceutical compositions comprising highly pure amphetamine and amphetamine-class compounds resulting from the synthesis of chiral and racemic amphetamine derivatives by stereospecific, regioselective cuprate addition reaction with aziridine phosphoramidate compounds, and to methods of manufacturing, delivering, and using the amphetamine compounds resulting from the synthesis of chiral and racemic amphetamine derivatives by stereospecific, regioselective cuprate addition reaction with aziridine phosphoramidate compounds.

专利号:US-5321143-A
优先权日:1988-05-26
标题 :Ruthenium-catalyzed production of cyclic sulfates
发明人：SHARPLESS K BARRY; GAO YUN
权利人:MASSACHUSETTS INST TECHNOLOGY
摘要:A ruthenium catalyzed method to synthesize cyclic sulfate compounds from the corresponding cyclic sulfites, and the cyclic sulfate reaction products obtained by this method. These cyclic sulfates further react with selected nucleophiles to give various substituted products. The method is an efficient means for the synthesis of chiral building blocks from tartaric acid enantiomers in high yields using an overall two-stage, one-pot reaction procedure. The chiral compounds can be transformed by nucleophilic reactions into chiral building blocks useful for the synthesis of natural biologically active products, such as antibiotics and pheromones.

专利号:US-5112990-A
优先权日:1988-05-26
标 题 :Ruthenium-catalyzed production of cyclic sulfates
发明人：SHARPLESS K BARRY; GAO YUN
权利人:MASSACHUSETTS INST TECHNOLOGY
摘要:A ruthenium catalyzed method to synthesize cyclic sulfate compounds from the corresponding cyclic sulfites, and the cyclic sulfate reaction products obtained by this method. These cyclic sulfates further react with selected nucleophiles to give various substituted products. The method is an efficient means for the synthesis of chiral building blocks from tartaric acid enantiomers in high yields using an overall two-stage, one-pot reaction procedure. The chiral compounds can be transformed by nucleophilic reactions into chiral building blocks useful for the synthesis of natural biologically active products, such as antibiotics and pheromones.