CAS: 60022-62-0; H-Ser-Obzl.Hcl

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CAS号56-45-1 L-丝氨酸 | CAS号100-51-6 苯甲醇 | CAS号73724-45-5 Fm°C-L-丝氨酸 | CAS号145362-72-7 BENZYL N-(DIPHE...

N-叔丁氧羰基-L-丝氨酸置于盐酸体系中,用 甲醇 作为反应溶剂,化学反应 3.0H,以69%的收率获得产物l-丝氨酸苄酯盐酸盐
参考文献:含有脱氢丙氨酸,脱氢苯丙氨酸和恶唑的四肽的合成作为构建折叠体和仿生催化剂的构件
标题:含有脱氢丙氨酸,脱氢苯丙氨酸和恶唑的四肽的合成作为构建折叠体和仿生催化剂的构件
摘要:将脱氢氨基酸或恶唑片段掺入肽链伴随着扭曲的三维结构,并且还能够引入非典型的侧链取代基.因此,这些化合物可以成为获得新折叠体和/或人工酶(artzymes)的构件.在本文中,描述了产生这种结构单元的有效合成程序--含有甘氨酰脱氢丙氨酸,甘氨酰脱氢苯丙氨酸和甘氨酰恶唑亚基的四肽.含有丝氨酸的肽被用作底物,用于将它们转化为含有脱氢丙氨酸和氨基甲基恶唑-4-羧酸的肽,同时考虑在合成的最后步骤将这些片段引入长链肽的可能要求.
DOI:10.3390/molecules27092611

专利信息

专利号:US-8153100-B2
优先权日:2007-01-11
标题 :Methods and compositions for F-18 labeling of proteins, peptides and other molecules
发明人：MCBRIDE WILLIAM J; D SOUZA CHRISTOPHER A; GOLDENBERG DAVID M
权利人:MCBRIDE WILLIAM J; D SOUZA CHRISTOPHER A; GOLDENBERG DAVID M; IMMUNOMEDICS INC
摘要:The present application discloses compositions and methods of synthesis and use of 18 F or 19 F labeled molecules of use in PET or MRI imaging. The labeled molecules may be peptides or proteins, although other types of molecules may be labeled. Preferably, the 18 F or 19 F is conjugated to a targeting molecule by formation of a metal complex and binding of the 18 F- or 19 F-metal complex to a chelating moiety. Alternatively, the metal may first be conjugated to the chelating group and subsequently the 18 F or 19 F bound to the metal. In other embodiments, the 18 F or 19 F labeled moiety may comprise a targetable construct used in combination with a bispecific antibody to target a disease-associated antigen. The 18 F or 19 F labeled targetable construct peptides are stable in serum at 37° C. for a sufficient time to perform PET or MRI imaging.

专利号:US-8147800-B2
优先权日:2007-01-11
标 题 :Methods and compositions for F-18 labeling of proteins, peptides and other molecules
发明人：MCBRIDE WILLIAM J; D SOUZA CHRISTOPHER A; GOLDENBERG DAVID M
权利人:MCBRIDE WILLIAM J; D SOUZA CHRISTOPHER A; GOLDENBERG DAVID M; IMMUNOMEDICS INC
摘要:The present application discloses compositions and methods of synthesis and use of F-18 labeled molecules of use, for example, in PET imaging techniques. The labeled molecules may be peptides or proteins, although other types of molecules may be labeled by the described methods. Preferably, the F-18 may be conjugated to a targeting molecule by formation of a metal complex and binding of the F-18-metal complex to a chelating moiety. Alternatively, the metal may first be conjugated to the chelating group and subsequently the F-18 bound to the metal. In other embodiments, the F-18 labeled moiety may comprise a targetable construct used in combination with a bispecific or multispecific antibody to target F-18 to a disease-associated antigen, such as a tumor-associated antigen. The F-18 labeled targetable construct peptides are stable in serum at 37° C. for a sufficient time to perform PET imaging analysis.

专利号:CN-103524595-A
优先权日:2013-10-14
标 题:A new method for the synthesis of pseudo-dipeptide Fmoc-Gly-Thr(ψMe, Me pro)-OH at the kilogram level

专利号:WO-2007055698-A1
优先权日:2005-11-10
标 题:Improved method for making amino acid clycosides and glycopeptides
发明人：POLT ROBIN
权利人:UNIV ARIZONA; POLT ROBIN
摘要:The invention relates to an improved method of preparing amino glycosides and glycopeptides. The method involves reacting an diarylketimine with an amino acid having a hydroxal side chain to produce an imino-bound intermediate compound. This intermediate is then reacted with an acetylated sugar residue under suitable conditions to yield amino glycoside. The synthetic amino glycoside may be incorporated into a peptide chain under conditions compatible with standard glycopeptide synthesis reactions.