专利号:US-6252105-B1 优先权日:1998-07-06 标题:Synthesis of low-fluoride organic compounds 发明人:BRAUN MAX; EICHER JOHANNES; JANSSENS FRANCINE; EICHHOLZ KERSTIN; PALSHERM STEFAN 权利人:SOLVAY FLUOR & DERIVATE 摘要:Organic compounds, e.g. fluorinated organic compounds such as fluorinated carboxylic acids or fluorinated carboxylic acid chlorides, may contain small amounts of carboxylic acid fluorides, hydrogen fluoride or hydrolyzable fluoride, which during the preparation of derivatives of the fluorinated organic compounds, for example by esterification, may yield corrosive fluorides or hydrogen fluoride. The invention is a method for the synthesis and/or purification of preferably fluorinated organic compounds such as carboxylic acids, carboxylic acid chlorides and derivatives such as esters thereof, starting from corresponding carboxylic acid chlorides containing acid fluorides or hydrolyzable fluoride, and alcohols under the catalytic action of 'onium' salts of carboxylic acids, to obtain products which have a low fluoride content. Alternatively, an inorganic oxide adsorbent is utilized. The method is especially suitable for the synthesis of esters of trifluoroacetic acid, chlorodifluoroacetic acid, trifluoroacetoacetic acid and/or difluoroacetoacetic acid.
专利号:US-2015239796-A1 优先权日:2014-02-19 标题:One pot synthesis of 18f labeledtrifluoromethylated compounds with difluoro(iodo)methane 发明人:RüHL THOMAS; RISS PATRICK; RAFIQUE WAQAS 权利人:UNIV OSLO 摘要:The present invention relates to compositions and methods for the synthesis of 18 F labeled compounds. In particular, the present invention relates to a copper (I) mediated one pot method for 18 F-trifluoromethylation of aromatic- or heteroaromatic halides with difluoro(iodo)methane (e.g., for use at PET imaging agents).
专利号:US-2005106689-A1 优先权日:2002-03-21 标 题:Synthesis of aminocrotonates 发明人:BRAUN MAX; BRAUKMUELLER SASKIA 权利人:SOLVAY FLUOR & DERIVATE 摘要:3-aminocrotonate compounds, e.g. diesters, which are substituted on the C-4 atom by at least two chlorine and/or fluorine atoms, are produced by reacting corresponding acetoacetate compounds with ammonia and primary and secondary amines while simultaneously or subsequently eliminating water. The reaction is carried out in the presence of onium salts formed from primary or secondary amines and carboxylic acids. Preferably, two phases are formed; one phase containing the crotonate compound product with a good degree of purity and the other phase containing the onium salt and water.
专利号:US-3625951-A 优先权日:1970-12-23 标 题 :Preparation of 3,4-disubstituted-delta-2-1,2,-triazoline-5-thiones 发明人:CEBALO TONY 权利人:AIR PROD & CHEM 摘要:The invention relates to the method of synthesis of certain 3,4disubstituted- Delta 2-1,2,4-triazoline-5-thiones by reacting the appropriate alkylthiosemicarbazide with certain fluoroalkylcarboxylic acids. The reaction in its preferred embodiment is carried out by azeotropic distillation of byproduct water.
专利号:US-8884051-B2 优先权日:2010-10-20 标题:Synthesis of methylene malonates using rapid recovery in the presence of a heat transfer agent 发明人:MALOFSKY BERNARD M; MALOFSKY ADAM G; DEY TANMOY; SULLIVAN JEFFREY M; CHEN YANGBIN; WOJCIAK STANLEY C; COCKREM MICHAEL C 权利人:MALOFSKY BERNARD M; MALOFSKY ADAM G; DEY TANMOY; SULLIVAN JEFFREY M; CHEN YANGBIN; WOJCIAK STANLEY C; COCKREM MICHAEL C; BIOFORMIX INC 摘要:The present invention provides a method of making a methylene malonate monomer that includes the steps of reacting a malonic acid ester with a source of formaldehyde optionally in the presence of an acidic or basic catalyst and optionally in the presence of an acidic or non-acidic solvent to form reaction complex. The reaction is optionally performed in the presence of or contacted with an energy transfer means such as a heat transfer agent, a heat transfer surface, a source of radiation or a laser such that reaction complex is substantially vaporized to produce a vapor phase comprising methylene malonate monomer which may be isolated. The present invention further provides methylene malonate monomers prepared by the method of the invention, as well as compositions and products formed from the methylene malonate monomers, including monomer-based products (e.g., inks, adhesives, coatings, sealants or reactive molding) and polymer-based products (e.g., fibers, films, sheets, medical polymers, composite polymers and surfactants).
专利号:US-2009264648-A1 优先权日:2008-01-14 标题:Synthesis of pyrazoles 发明人:CHEW WARREN; WANG ZHENG; CHEAL GLORIA; BERTRAND MARTIAL; POTOSKI JOHN; MIRMEHRABI MAHMOUD; NENCINI ARIANNA; ZANALETTI RICCARDO 权利人:WYETH CORP; SIENA BIOTECH SPA 摘要:The present invention provides compounds and compositions, methods of making them, and methods of using them to modulate α7 nicotinic acetylcholine receptors and/or to treat any of a variety of disorders, diseases, and conditions. Provided compounds can affect, among other things, neurological, psychiatric and/or inflammatory system.
摘要:Sharma, U.; Kumar, R.; Gupta, S. S.; Chandra, D., Science of Synthesis Knowledge Updates, (2022) 2, 261. 摘要:J. L. Kurz and J. M. Farrar, J. Am. Chem. Soc. 91, 6057 (1969). 摘要:Murai, T., Science of Synthesis: Knowledge Updates, (2024) 2, 405.