CAS: 822-55-9; 4-(Hydroxymethyl)Imidazole

该化合物是一种有机化合物,其特点是其一丁二二甲环形结构,即由五人组成的含有两个氮原子的热循环化合物;该化合物在一硝二甲圆环的5处位置上具有氢氧化甲基组(-CH2OH),有助于其反应和潜在应用;该产品一般是白色的,非白色的固体,在水和各种有机溶剂中可溶解,使其适应不同的化学反应;该水氧化甲基组合的存在允许氢结合,这可能影响其物理特性和与其他分子的相互作用. 1H-Imidazole-5-甲醇在各个领域中都感兴趣,包括医药化学和生物化学,因为它作为制药和其他生物活性化合物合成的建筑块具有潜在作用,其独特的结构和功能组使它成为化学合成和药物发现研究与发展的宝贵化合物.

英文名称4-(Hydroxymethyl)Imidazole
中文名称4-(羟甲基)咪唑
IUPAC名称(1H-imidazol-4-yl)methanol
其它别名1H-Imidazol-4-Ylmethanol; 1H-Imidazol-4-Yl-Methanol; 1H-Imidazol-4-Ylmethanol; 4-(Hydroxymethyl)Imidazole; 4-Imidazolylmethanol; 4-Methylol-1H-Imidazole; 4(5)-(Hydroxymethyl)Imidazole; 4-Imidazolemethanol
CAS编号822-55-9
MFCD编号:MFCD00266718
EINECS号:628-579-0
FDA UNII编号:QD0132T507
分子式:C4H6N2O
分子量:98.1
产品CID: 1813806
产品分类有机原料 → 杂环化合物

相似结构搜索
InChIKey: QDYTUZCWBJRHKK-UHFFFAOYSA-N
InChI=1S/C4H6N2O/c7-2-4-1-5-3-6-4/h1,3,7H,2H2,(H,5,6)…
计算化学: 氢键受体数2.0氢键供体数2.0可旋转键数1.0

MSDS等安全信息

GHS象形图
GHS符号GHS07;
注释: Exclamation mark
危险类别特定目标器官毒性 - 单次接触类别3
皮肤腐蚀/刺激类别2
严重眼刺激类别2A
严重眼刺激类别2
警示词Warning(警告)
危险描述H335 |可能引起呼吸道刺激.
H315 |造成皮肤刺激.
H319 |造成严重眼刺激.
防范说明P261-P264-P271-P280-P302+P352-P305+P351+P338
UN编号NONH for all modes of transport
危险品标志Xi
风险等级Irritant
安全声明26-36
危险类别码36/37/38
WGK Germany3

欧盟法规

ECHA物质C&L通报

上下游产品

合成工艺路线路线简述

合成目标产物 Imidazole-4-Methanol 主要起始原料 1H-Imidazole-4-Carboxylic Acid
3034-50-2 = 822-55-9
反应条件:1.1 Reagents: Sodium Borohydride Solvents: Ethanol; 3 H,20 °C
标题:Oxidative Protein Folding Promotion By Imidazoyl-Conjugated Thiol
作者:Okada,Shunsuke; Et Al
参考文献:Chemistry Letters 日期:2023 卷标:52(3) 页码:202-205]

96-26-4 = 822-55-9
反应条件:1.1 Reagents: Cupric Acetate,Ammonium Hydroxide Solvents: Water
标题:Design And Synthesis Of New 1,4-Dihydropyridines Containing 4(5)-Chloro-5(4)-Imidazolyl Substituent As A Novel Calcium Channel Blocker
作者:Iman,Maryam; Et Al
参考文献:Archives Of Pharmacal Research 日期:2011 卷标:34(9) 页码:1417-1426]

822-55-9 = 822-55-9 [标题:Reaction Conditions
标题:Product Class 3: Imidazoles
作者:Grimmett,M. R.
参考文献:Science Of Synthesis 日期:2002 卷标:12 页码:325-528]

80304-50-3 = 822-55-9
反应条件:1.1 Reagents: Hydrogen Catalysts: Palladium
标题:The Chemical Simulation Of The "Atp-Imidazole" Cycle
作者:Ranganathan,Darshan; Et Al
参考文献:Tetrahedron 日期:1986 卷标:42(16) 页码:4481-92]

85102-99-4 = 822-55-9
反应条件:1.1 Reagents: Sodium Borohydride Solvents: Methanol2.1 Reagents: Hydrogen Catalysts: Palladium
标题:The Chemical Simulation Of The "Atp-Imidazole" Cycle
作者:Ranganathan,Darshan; Et Al
参考文献:Tetrahedron 日期:1986 卷标:42(16) 页码:4481-92]

23785-21-9 = 822-55-9
反应条件:1.1 Solvents: Diethyl Ether
标题:Imidazoles. Iii. 1-Substituted Analogs Of Histidine And Histamine
作者:Jones,Reuben G.; Et Al
参考文献:Journal Of The American Chemical Society 日期:1949 卷标:71 页码:2444-8]

57-48-7 = 822-55-9
反应条件:1.1 Reagents: Ammonia,Basic Copper Carbonate Solvents: Water; 30 Min,Reflux; 2 H,Reflux; 3 H,Reflux -> 0 °C1.2 Reagents: Thioacetamide Solvents: Water; 2 H,50 °C
标题:Solvents From Biorenewable Sources: Ionic Liquids Based On Fructose
作者:Handy,Scott T.; Et Al
参考文献:Organic Letters 日期:2003 卷标:5(14) 页码:2513-2515]

57-48-7 = 822-55-9
反应条件:1.1 Reagents: Copper Carbonate,Ammonia,Oxygen,Copper Hydroxide
标题:Formaldehyde
作者:Concepcion,Arnel B.; Et Al
参考文献:E-Eros Encyclopedia Of Reagents For Organic Synthesis 日期:2001 卷标:1 页码:1-6]

96-26-4 + 463-52-5 = 822-55-9 [标题:Reaction Conditions
标题:Preparation Of α,β-Dimethylhistamine And Stereoisomers As Selective Histaminic H3 Receptor Agonists
参考文献:European Patent Organization]

96-26-4 = 822-55-9
反应条件:1.1 Reagents: Cupric Acetate,Ammonia Solvents: Water; 15 Min,Rt; 5 H,Heated; Cooled1.2 Reagents: Hydrogen Sulfide Solvents: Water; 3 H,Rt
标题:Efficient Synthesis Of Imidazole Derivatives: An Important Synthon For The Preparation Of Biologically Active Compounds
作者:Davood,Asghar; Et Al
参考文献:Turkish Journal Of Chemistry 日期:2008 卷标:32(3) 页码:389-395]

14891-73-7 = 822-55-9 [标题:Reaction Conditions
标题:Product Class 3: Imidazoles
作者:Grimmett,M. R.
参考文献:Science Of Synthesis 日期:2002 卷标:12 页码:325-528]

503-66-2 + 463-52-5 = 822-55-9
反应条件:1.1 Reagents: Hydrochloric Acid,Ammonia Solvents: Isopropanol
标题:Preparation Of (Diarylethyl)Imidazole Derivatives As Antidepressants
参考文献:European Patent Organization]

96-26-4 + 463-52-5 = 822-55-9 [标题:Reaction Conditions
标题:Product Class 3: Imidazoles
作者:Grimmett,M. R.
参考文献:Science Of Synthesis 日期:2002 卷标:12 页码:325-528]

14891-73-7 = 822-55-9 [标题:Reaction Conditions
标题:Product Class 3: Imidazoles
作者:Grimmett,M. R.
参考文献:Science Of Synthesis 日期:2002 卷标:12 页码:325-528]

7164-98-9 = 822-55-9 [标题:Reaction Conditions
标题:Product Class 3: Imidazoles
作者:Grimmett,M. R.
参考文献:Science Of Synthesis 日期:2002 卷标:12 页码:325-528]

288-32-4 = 822-55-9 [标题:Reaction Conditions
标题:Product Class 3: Imidazoles
作者:Grimmett,M. R.
参考文献:Science Of Synthesis 日期:2002 卷标:12 页码:325-528

1H-咪唑-4-甲酸以硫酸作为反应溶剂,化学反应生成 4-(羟甲基)咪唑
参考文献:Process Of Reduction
标题:Process Of Reduction
摘要:一种用于制备4-(羟甲基)-咪唑的电化学过程,这些化合物可用作化学中间体.

海关参考信息

2905110000-甲醇
💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
详情请参考：📖 海关编码查询和海关进出口税则

专利信息

专利号:EP-1871745-B1
优先权日:2005-04-15
标题:Preparation of 2-substituted 4-chloro-5-formylimidazoles by vilsmeier reaction of the condensation product of glycine and an imido ester with a formamide in the presence of a triflate (trifluormethanesulphonate) catalyst
发明人：RAJNIKANT VYAS JANMEJAY; SATYA VARMA NIDADAVOLU VENKATA; PRAKASH SINGH ANAND
权利人:DISHMAN PHARMACEUTICALS AND CH
摘要:The invention relates to a preparation process for 2-substituted 5-formylimidazoles, wherein the intermediate high-pressurized synthesis of an 2-substituted 4-hydroxymethylimidazole as known in the art is conveniently avoided, and wherein much higher yields are obtained. Instead, it is proposed to prepare such 2-substituted 5-formylimidazoles via a one-pot synthesis involving 2-substituted 4-chloro-5-formylimidazole, thereby employing an additional hydrodehalogenation step. Moreover, it is found that the yield and purity of 2-substituted 4-chloro-5-formylimidazole itself can be significantly improved using a triflate catalyst in the preparation process.

专利号:US-11848117-B2
优先权日:2017-12-06
标题:Thin and uniform silver nanowires, method of synthesis and transparent conductive films formed from the nanowires
发明人：HU YONGXING; LI YING-SYI; YANG XIQIANG; ANG JING SHUN; VIRKAR AJAY
权利人:C3 NANO INC
摘要:Highly uniform and thin silver nanowires are described having average diameters below 20 nm and a small standard deviation of the diameters. The silver nanowires have a high aspect ratio. The silver nanowires can be characterized by a small number of nanowires having a diameter greater than 18 nm as well as with a blue shifted narrow absorption spectrum in a dilute solution. Methods are described to allow for the synthesis of the narrow uniform silver nanowires. Transparent conductive films formed from the thin, uniform silver nanowires can have very low levels of haze and low values of Î”L*, the diffusive luminosity, such that the transparent conductive films can provide little alteration of the appearance of a black background.

专利号:WO-2006038223-A1
优先权日:2004-10-06
标题:A process for preparation of 2-n-butyl -4-chloro - 1 - {[2`- (2-triphenylmethyl - 2h - tetrazole - 5- yl) - 1, 1â€™ - biphenyl-4-yl] methyl}-lh- imidazoie-5-methanol (intermediate of losartan)
发明人：CHAVA SATYANARYANA; VASIREDDY UMAMAHESWAR RAO; VELLANKI SIVA RAM PRASAD; BALUSU RAJABABU
权利人:MATRIX LAB LTD; CHAVA SATYANARYANA; VASIREDDY UMAMAHESWAR RAO; VELLANKI SIVA RAM PRASAD; BALUSU RAJABABU
摘要:The present invention relates to a process for preparation of N-substituted heterocyclic derivative,2-n-Butyl-4-chloro- 1 - { [2' -(2-triphenylmethyl-2H-tetrazole-5-yl)- 1,1' -biphenyl -4-yl] methyl} -lH-imidazole-5-methanol, an important intermediate in the synthesis of Losartan and its pharmaceutically acceptable salts using phase transfer catalyst and minimal number of solvents with improved yield.

专利号:US-2004053999-A1
优先权日:1997-09-17
标题 :Novel compounds and methods for synthesis and therapy
发明人：BISCHOFBERGER NORBERT W; DAHL TERRENCE C; HITCHCOCK MICHAEL J M; KIM CHOUNG U; LEW WILLARD; LIU HONGTAO; MILLS ROGER G; WILLIAMS MATTHEW A
摘要:Novel compounds are described. The compounds generally comprise an acidic group, a basic group, a substituted amino or N-acyl and a group having an optionally hydroxylated alkane moiety. Pharmaceutical compositions comprising the inhibitors of the invention are also described. Methods of inhibiting neuraminidase in samples suspected of containing neuraminidase are also described. Antigenic materials, polymers, antibodies, conjugates of the compounds of the invention with labels, and assay methods for detecting neuraminidase activity are also described.

专利号:US-6225341-B1
优先权日:1995-02-27
标题:Compounds and methods for synthesis and therapy
发明人：BISCHOFBERGER NORBERT W; KIM CHOUNG U; LEW WILLARD; LIU HONGTAO; WILLIAMS MATTHEW A
权利人:GILEAD SCIENCES INC
摘要:Novel compounds are described. The compounds generally comprise an acidic group, a basic group, a substituted amino or N-acyl and a group having an optionally hydroxylated alkane moiety. Pharmaceutical compositions comprising the inhibitors of the invention are also described. Methods of inhibiting neuraminidase in samples suspected of containing neuraminidase are also described. Antigenic materials, polymers, antibodies, conjugates of the compounds of the invention with labels, and assay methods for detecting neuraminidase activity are also described.

专利号:WO-9310106-A1
优先权日:1991-11-18
标题 :Tetrazolylphenylboronic acid intermediates for the synthesis of aii receptor antagonists