CAS: 92-88-6; [1,1'-Biphenyl]-4,4'-Diol

• 英文名称[1,1'-Biphenyl]-4,4'-Diol
• 中文名称4,4'-二羟基联苯
• IUPAC名称[1,1'-biphenyl]-4,4'-diol
• 其它别名联苯-4,4'-二醇; 44联苯酚
• CAS编号92-88-6
• MFCD编号:MFCD00002348
• EINECS号:202-200-5
• FDA UNII编号:R8994A0904
• 分子式:C12H10O2
• 分子量:186.21
• 产品CID: 1967644
• 产品分类有机原料→分子砌块→芳环类化合物→苯类化合物

• 相似结构搜索
• 产品信息参考
• InChIKey: VCCBEIPGXKNHFW-UHFFFAOYSA-N
• InChI=1S/C12H10O2/c13-11-5-1-9(2-6-11)10-3-7-12(14)8-4-10/h1-8,13-14H…
• 计算化学: 氢键受体数2.0氢键供体数2.0可旋转键数1.0

物理性质

• 熔点280-282°C
• 沸点280.69 °C at 760 mmHg
• 闪点176.1±15.5 °C
• 密度1.2±0.1 g/cm3
• pKa:9.74±0.26(预测)
• PSA:40.46
• LogP:2.7648
• 折射率1.640
• 蒸汽压0.0±0.8 mmHg at 25°C
• 溶解性Sparingly Soluble
• 敏感性1.白色片状结晶，本品无毒。2.易溶于乙醚、乙醇、乙酸乙酯、丙酮和氢氧化钠，微溶于苯和氯甲烷，不溶于汽油、四氯化碳和水。
• 外观形态类白色至浅米色或浅灰色粉末
• 储存条件密封, 常温干燥保存
• 产品应用(1)用做液晶聚合物的中间体原料.(2)合成高聚物方面,由于其耐热性能极佳,故用作聚酯,聚氨酯,聚碳酸酯,聚砜及环氧树脂的改性单体,用以制造优良的工程塑料和复合材料.(3)用作橡胶防老剂和塑料抗氧剂.(4)染料中间体或石油制品的稳定剂.
• 性质描述白色片状结晶,易溶于乙醚,乙醇,乙酸乙酯,丙酮和氢氧化钠,不溶于汽油,四氯化碳和水.

MSDS等安全信息

• GHS象形图
• GHS符号GHS07;
  注释: Exclamation mark
• 危险类别皮肤致敏 类别1
  水生慢性毒性 类别3
  急性毒性 类别4(经皮)
  特定目标器官毒性 - 单次接触 类别3
  皮肤腐蚀/刺激 类别2
  严重眼刺激 类别2
  水生慢性毒性 类别2
  致突变性 类别2
  严重眼损伤 类别1
  自热物质 类别2
• 警示词Warning(警告)
• 危险描述H317 |可能引起皮肤过敏反应.
  H412 |对水生生物有害并具有长期持续影响.
  H312 |皮肤接触有害.
  H335 |可能引起呼吸道刺激.
  H315 |造成皮肤刺激.
  H319 |造成严重眼刺激.
  H411 |对水生生物有毒并具有长期持续影响.
  H341 |怀疑导致遗传缺陷.
  H318 |造成严重眼损伤.
  H252 |大量自热;可能着火.
• 防范说明P261-P272-P273-P280-P302+P352-P363-P407-P420-P501
• 危险等级4.2
• UN编号3088.0
• 危险品标志Xn
• 包装等级Ⅲ
• 安全声明26-36-24/25-36/37
• 危险类别码21-36/37/38-37/38/68-36
• WGK Germany2

欧盟法规

上下游产品

合成工艺路线路线简述

• 合成目标产物 4,4'-Biphenol 主要起始原料 3,3',5,5'-Tetra(Tert-Butyl)[1,1'-Biphenyl]-4,4'-Diol
• 22726-67-6 = 92-88-6
  反应条件:1.1 Reagents: Hydrogen Peroxide Catalysts: Hydrogen Ion
  标题:N-Hydroxyphthalimide
  作者:Gambarotti,Cristian; Punta,Carlo; Recupero,Francesco; Zlotorzynska,Maria; Sammis,Glenn
  参考文献:E-Eros Encyclopedia Of Reagents For Organic Synthesis 日期:2013 卷标:1 页码:1-9]
  
  = 92-88-6
  反应条件:1.1 Reagents: Styrene,Potassium Carbonate Catalysts: Iron Oxide (Fe3O4) (Core@shell Hybrid With Mg/al-Ldh And Support For Pdau-Pvp Nanoclusters),Poly(Vinylpyrrolidone) (Protection For Palladium-Gold Alloy Nanoclusters),Gold Alloy,Nonbase,Au,Pd (Immobilized On Fe3O4@mgal-Ldh And Pvp Protected) Solvents: Dimethylformamide,Water; 1 H,120 °C
  标题:Facile Synthesis Of Magnetic Recyclable Palladium-Gold Alloy Nanoclusters Catalysts Pdaur/fe3O4@ldh And Its Catalytic Applications In Heck Reaction
  作者:Li,Jin; Wang,Yajuan; Jiang,Shunwang; Zhang,Hui
  参考文献:Journal Of Organometallic Chemistry 日期:2018 卷标:878 页码:84-95]
  
  1094-86-6 = 92-88-6
  反应条件:1.1 Catalysts: 1H-Imidazolium,1,3-Disulfo-,Sulfate (1:1) Solvents: Methanol; 5 Min,Rt
  标题:Preparation,Characterization And Use Of 1,3-Disulfonic Acid Imidazolium Hydrogen Sulfate As An Efficient,Halogen-Free And Reusable Ionic Liquid Catalyst For The Trimethylsilyl Protection Of Hydroxyl Groups And Deprotection Of The Obtained Trimethylsilanes
  作者:Shirini,Farhad; Khaligh,Nader Ghaffari; Akbari-Dadamahaleh,Somayeh
  参考文献:Journal Of Molecular Catalysis A: Chemical 日期:2012 卷标:365 页码:15-23]
  
  = 92-88-6
  反应条件:1.1 Reagents: Indium,Lithium Chloride Catalysts: Palladium Solvents: Dimethylformamide; 2.5 H,100 °C1.2 Reagents: Sodium Thiosulfate Solvents: Water
  标题:Palladium-Catalyzed Inter- And Intramolecular Coupling Reactions Of Aryl And Vinyl Halides Mediated By Indium
  作者:Lee,Phil Ho; Seomoon,Dong; Lee,Kooyeon
  参考文献:Organic Letters 日期:2005 卷标:7(2) 页码:343-345]
  
  = 92-88-6
  反应条件:1.1 Reagents: Toluene Catalysts: Nafion 117
  标题:Catalysis By Solid Superacids. 21. Nafion-H Catalyzed De-Tert-Butylation Of Aromatic Compounds
  作者:Olah,George A.; Prakash,G. K. Surya; Iyer,Pradeep S.; Tashiro,Masashi; Yamato,Takehiko
  参考文献:Journal Of Organic Chemistry 日期:1987 卷标:52(9) 页码:1881-4]
  
  92-86-4 = 92-88-6
  反应条件:1.1 Reagents: Sodium Hydroxide Catalysts: Copper Oxide (Cu2O) Solvents: Ethanol,Water
  标题:The Copper-Catalyzed Hydrolysis Of 4,4'-Dibromobiphenyl Derivatives
  作者:Hanaoka,Takaaki; Yoshihiro,Sugi; Uchi,Kazutaka; Abe,Yoshimoto; Misono,Takahisa
  参考文献:Sekiyu Gakkaishi 日期:1994 卷标:37(3) 页码:328-32]
  
  71597-85-8 = 92-88-6
  反应条件:1.1 Reagents: Oxygen Catalysts: Cupric Acetate,Palladium Diacetate Solvents: Dimethyl Sulfoxide,Water; 14 H,Rt
  标题:"Benchtop" Biaryl Coupling Using Pd/cu Cocatalysis: Application To The Synthesis Of Conjugated Polymers
  作者:Minus,Matthew B.; Moor,Sarah R.; Pary,Fathima F.; Nirmani,L. P. T.; Chwatko,Malgorzata; Et Al
  参考文献:Organic Letters 日期:2021 卷标:23(8) 页码:2873-2877]
  
  71597-85-8 = 92-88-6
  反应条件:1.1 Reagents: Potassium Carbonate Catalysts: Palladium (Complexes With Superparamagnetic Iron Oxide Nanoparticle-Supported Schiff Base Of Diethylenetriamine And Diacetyl Monooxime) Solvents: Dimethylformamide; 30 Min,90 °C
  标题:Facile And Efficient Protocols For C-C And C-N Bond Formation Reactions Using A Superparamagnetic Palladium Complex As Reusable Catalyst
  作者:Karimi Zarchi,Mohammad Ali; Darbandizadeh Mohammad Abadi,Seyed Shahab Addin
  参考文献:Research On Chemical Intermediates 日期:2019 卷标:45(5) 页码:2605-2639]
  
  = 92-88-6
  反应条件:1.1 Reagents: Sodium Tetraphenylborate,Sodium Carbonate Catalysts: Palladium (Complexes With Fe3O4 Magnetic Nanoparticle Supported S-(3-Trimethoxysilylpropyl)-2-Aminothiobenzamide),S-[3-(Trimethoxysilyl)Propyl] 2-Aminobenzenecarbothioate (Fe3O4 Magnetic Nanoparticle Supported; Palladium Complexes) Solvents: Water; 15 Min,80 °C
  标题:Palladium-S-Propyl-2-Aminobenzothioate Immobilized On Fe3O4 Magnetic Nanoparticles As Catalyst For Suzuki And Heck Reactions In Water Or Poly(Ethylene Glycol)
  作者:Ghorbani-Choghamarani,Arash; Tahmasbi,Bahman; Moradi,Parisa
  参考文献:Applied Organometallic Chemistry 日期:2016 卷标:30(6) 页码:422-430]
  
  128-38-1 = 92-88-6
  反应条件:1.1 Catalysts: P-Toluenesulfonic Acid Solvents: Diethylbenzene
  标题:Preparation Of 4,4'-Biphenols As Materials For Heat-Resistant Engineering Plastics
  参考文献:Japan]
  
  71597-85-8 = 92-88-6
  反应条件:1.1 Reagents: Oxygen Catalysts: Methyl α-D-Glucopyranoside,Cupric Acetate Solvents: Dimethylformamide; 90 Min,40 °C
  标题:Cu(Ii)-Catalyzed Homocouplings Of (Hetero)Arylboronic Acids With The Assistance Of 2-O-Methyl-D-Glucopyranose
  作者:Yuan,Chunling; Zheng,Li; Zhao,Yingdai
  参考文献:Molecules 日期:2019 卷标:24(20)]
  
  = 92-88-6
  反应条件:1.1 Reagents: Sodium Methoxide Catalysts: Tetrabutylammonium Bromide,Palladium,Basolite Z 1200 Solvents: Water; 20 H,80 °C
  标题:A Highly Active Heterogeneous Palladium Catalyst For The Suzuki-Miyaura And Ullmann Coupling Reactions Of Aryl Chlorides In Aqueous Media
  作者:Yuan,Bizhen; Pan,Yingyi; Li,Yingwei; Yin,Biaolin; Jiang,Huanfeng
  参考文献:Angewandte Chemie 日期:2010 卷标:49(24) 页码:4054-4058]
  
  128-38-1 = 92-88-6
  反应条件:1.1 Catalysts: Methanesulfonic Acid; 2 H,150 °C
  标题:Preparation Of Biphenols By Oxidative Coupling Of Alkylphenols Using A Recyclable Copper Catalyst
  参考文献:World Intellectual Property Organization]
  
  128-38-1 = 92-88-6
  反应条件:1.1 Reagents: Methanesulfonic Acid Solvents: Toluene; 2 H,150 °C
  标题:Preparation Of Tetraalkylbiphenols By The Oxidative Coupling Of Dialkylphenols Using A Recyclable Cuprous Halide-Diamine Complex Catalyst
  参考文献:United States]
  
  3432-00-6 = 92-88-6
  反应条件:1.1 Catalysts: Methanesulfonic Acid Solvents: 2,2,4-Trimethylpentane; 4 H,166 °C
  标题:Preparation Of Tetraalkylbiphenols By The Oxidative Coupling Of Dialkylphenols Using A Copper-Amino Complex Catalyst
  参考文献:United States]
  
  = 92-88-6
  反应条件:1.1 Reagents: Sodium Nitrite,Hydrochloric Acid,Sulfuric Acid Solvents: Water
  标题:Steroid Analogs Lacking Ring C. Iii. Synthesis Of 4-(Trans-4-Hydroxycyclohexyl)Cyclohexanone
  作者:Wilds,A. L.; Shunk,Clifford H.; Hoffman,Carl H.
  参考文献:Journal Of The American Chemical Society 日期:1954 卷标:76 页码:1733-6]
  
  = 92-88-6
  反应条件:1.1 Reagents: Zinc Catalysts: Choline Chloride,Zinc Chloride,Stannous Chloride; 35 - 40 °C; 3 H,35 - 40 °C
  标题:Green Method For Synthesis Of 4,4-Biphenol
  参考文献:China]
  
  71597-85-8 = 92-88-6
  反应条件:1.1 Reagents: Potassium Hydroxide Catalysts: Palladium Solvents: Water; 0.5 H,150 °C; 150 °C -> Rt1.2 Reagents: Hydrochloric Acid Solvents: Water; Acidified
  标题:Suzuki-Miyaura Coupling Of Halophenols And Phenol Boronic Acids: Systematic Investigation Of Positional Isomer Effects And Conclusions For The Synthesis Of Phytoalexins From Pyrinae
  作者:Schmidt,Bernd; Riemer,Martin
  参考文献:Journal Of Organic Chemistry 日期:2014 卷标:79(9) 页码:4104-4118]
  
  = 92-88-6
  反应条件:1.1 Reagents: Sodium Acetate,Potassium Hydroxide,Tetrabutylammonium Bromide Catalysts: Palladium Solvents: Ethanol,Water; 2 H,100 °C
  标题:Microwave-Assisted Aqueous Carbon-Carbon Cross-Coupling Reactions Of Aryl Chlorides Catalysed By Reduced Graphene Oxide Supported Palladium Nanoparticles
  作者:Zhang,Qingxiao; Mao,Zhan; Wang,Kaixuan; Phan,Nam Thanh Son; Zhang,Fang
  参考文献:Green Chemistry 日期:2020 卷标:22(10) 页码:3239-3247]
  
  71597-85-8 = 92-88-6
  反应条件:1.1 Reagents: Sodium Hydroxide Solvents: Water; 45 - 60 Min,120 - 130 °C
  标题:Organic Synthesis Via Magnetic Attraction: Benign And Sustainable Protocols Using Magnetic Nanoferrites
  作者:Nasir Baig,R. B.; Varma,Rajender S.
  参考文献:Green Chemistry 日期:2013 卷标:15(2) 页码:398-417]
  
  25839-81-0 = 92-88-6 + 80-09-1
  反应条件:1.1 Reagents: 1,3-Dimethyl-2-Imidazolidinone,Calcium Hydride,Cesium Hydroxide; 19 H,150 °C; 150 °C -> Rt1.2 Reagents: Hydrochloric Acid Solvents: Water; Rt
  标题:Hydroxylation-Depolymerization Of Oxyphenylene-Based Super Engineering Plastics To Regenerate Arenols
  作者:Minami,Yasunori; Et Al
  参考文献:Jacs Au 日期:2023 卷标:3(8) 页码:2323-2332

海关参考信息

• 2908199090-其他酚的卤化衍生物
  2908999090-其他酚的硝化衍生物
  2918290000-其他含酚基羧酸
  2905199090-其他饱和一元醇
• 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
• 详情请参考：📖 海关编码查询和海关进出口税则

专利信息

其他信息查阅

• ➥ 象形图和危险代码
• ➥ 防范代码详解
• ➥ 危险代码说明
• ➥ Globally Harmonized System
• ➥ REACH监管