CAS: 1075240-43-5; (4S,4As,5Ar,12As)-4,7-Bis(Dimethylamino)-3,10,12,12A-Tetrahydroxy-9-((Neopentylamino)Methyl)-1,11-Dioxo-1,4,4A,5,5A,6,11,12A-Octahydrotetracene-2-Carboxamide 4-Methylbenzenesulfonate

反应生成奥马环素
参考文献:Tetrahedron. Lett. 2008,49,6095-6100
标题:Tetrahedron. Lett. 2008,49,6095-6100

专利信息

专利号:US-2023357135-A1
优先权日:2020-06-11
标 题:Crystalline forms of omadacycline, methods of synthesis thereof and methods of use thereof
发明人：WARCHOL TADEUSZ; JOHNSTON SEAN M
权利人:PARATEK PHARM INNC
摘要:The present invention provides omadacycline crystalline freebase and methods of synthesis thereof. The present invention also provides pharmaceutical compositions comprising omadacycline crystalline freebase and methods of use thereof for treating bacterial infections. The present invention also provides methods of purifying crude omadacycline freebase that comprise crystallization to produce crystalline omadacycline freebase. The omadacycline crystalline freebase may also be used to prepare salts of omadacycline, e.g., a tosylate salt.

专利号:EP-4165016-A1
优先权日:2020-06-11
标题:Crystalline forms of omadacycline, methods of synthesis thereof and methods of use thereof

专利号:CA-3179596-A1
优先权日:2020-06-11
标 题:Crystalline forms of omadacycline, methods of synthesis thereof and methods of use thereof

专利号:CN-117616008-A
优先权日:2021-05-26
标题 :Synthesis method of 9-aminomethyl tetracycline compound

专利号:CN-119751291-A
优先权日:2025-01-07
标题 :A synthesis method of omadacycline and its application in preparations