CAS: 108-37-2; 1-Bromo-3-Chlorobenzene

上下游产品

bromobenzene 3-chlorobenzenediazonium m-nitrobromobenzene 3-chloro-aniline 1-bromo-5-chloro-2,4-dinitro-benzene m-chlorophenyltrimethylsilane 1,3-Dichlorobenzene (E)-1-(m-Chlorphenyl)but-1-en-3-in

3-Chlorobenzenediazonium Tetrafluoroborate置于四丁基溴化铵,对甲苯磺酸,Potassium Bromide体系中,用 甲酸 用作溶剂,化学反应 1.5H,反应生成间氯溴苯
参考文献:芳烃重氮盐的光化学 Sandmeyer 型卤化
标题:芳烃重氮盐的光化学 Sandmeyer 型卤化
摘要:在它被发现一百四十年后,桑德迈尔反应的关键限制被克服了.使用三卤化物盐作为介体能够将重氮盐光化学转化为相应的芳基卤化物,而无需使用有环境问题的过渡金属介体.形成多种芳基溴化物,氯化物和碘化物,对卤化的选择性优于氢化二重氮化,避免了从非卤化类似物中分离卤化产物的费力.@ruhrunibochum
Doi:10.1002/chem.202103669

专利信息

专利号:WO-2024153752-A1
优先权日:2023-01-20
标 题 :Stereoselective synthesis of intermediates and synthesis of quinagolids
发明人：RYBERG PER; PINESCHI MAURO; COMPARINI LUCREZIA
权利人:FERRING BV
摘要:Disclosed is a method for preparing compounds with improved stereoselectivities. The described compounds are useful intermediates and may find particular application in the synthesis of compounds containing an octahydrobenzoquinoline moiety (e.g. an octahydrobenzo[g]quinoline moiety), such as quinagolide and its derivatives. Also disclosed is a method for stereoselectively (e.g. enantioselectively) preparing an intermediate used in the existing manufacturing process for the synthesis of quinagolide this intermediate also finding utility in the synthesis of other compounds containing an octahydrobenzo[g]quinoline moiety, in particular those having a substituent at the 3- position on the octahydrobenzo[g]quinoline.

专利号:US-2025179012-A1
优先权日:2022-03-04
标 题:Synthesis of sulfur(vi) compounds and reagents for same
发明人：LOPCHUK JUSTIN MATTHEW; SHULTZ ZACHARY
权利人:H LEE MOFFITT CANCER CT & RES
摘要:This disclosure provides reagents and processes for the synthesis of organic compounds, more particularly reagents and processes for the asymmetric synthesis of sulfur (VI) containing organic compounds.

专利号:US-6958420-B2
优先权日:2002-07-19
标题:Synthesis of aminoarylboronic esters and substituted anilines from arenes via catalytic C-H activation/borylation/amination and uses thereof
发明人：MALECZKA JR ROBERT E; SMITH III MILTON R; HOLMES DANIEL
权利人:UNIV MICHIGAN STATE
摘要:A process is described for synthesizing aminoarylboronic esters of the general formula n n nwherein R, R 2 , and R 3 are each an alkyl, aryl, vinyl, alkoxy, carboxylic esters, amides, or halogen; Ar is any variety of phenyl, naphthyl, anthracyl, heteroaryl; and R 1 is alkyl, hydrogen, or aryl. The aminoarylboronic esters are produced via the metal-catalyzed coupling of arylboronic esters of the general formula n n nwherein R and R 1 are any non-interfering group and X is chloro, bromo, iodo, triflates, or nonaflates to amines (primary and secondary). In particular, a process is described for the synthesis of the aminoarylboronic esters via a step-wise or tandem process in which one catalytic event is a metal-catalyzed borylation and the other catalytic event is a metal-catalyzed amination.

专利号:EP-1314727-B1
优先权日:2001-11-23
标题 :Direct synthesis of quaternary phenanthridinium salts
发明人：CAPELLE NICOLAS; GALLO ROGER
权利人:MERIAL SAS
摘要:Process for the preparation of phenanthridinium quaternary salts (I) comprises reacting a halo-aromatic compound (II) with a phenyl boronic derivative (III) in a basic medium, in the presence of a palladium catalyst. Process for the preparation of phenanthridinium quaternary salts of formula (I) comprises reacting a halo-aromatic compound of formula (II) with a phenyl boronic derivative of formula (III) in a basic medium, in the presence of a palladium catalyst. R<3>, R<8> = an electro-attractor group having an electronegativity at last equal to that of nitro; R<5> = a non-chemically labile group; R<6> = aryl or 5-12C heteroaryl, which my be condensed and may have one or more hetero atoms; X<-> = a halide or hydrogen sulfate anion or a base joined to a mineral acid; X = halogen; R = H; R+R = a group of formula (i); n, n' = 0-4; R<9>, R<10> = H or 1-5C alkyl. Independent claims are also included for: (1) intermediates of formula (VI); and (2) the preparation of (VI). X1 = halogen.

专利号:US-2016073631-A1
优先权日:2013-03-04
标 题 :Process for the preparation of dihydropyrrole derivatives
发明人：EL QACEMI MYRIEM; SMITS HELMARS; CASSAYRE JEROME YVES; MULHOLLAND NICHOLAS PHILLIP; RENOLD PETER; GODINEAU EDOUARD; PITTERNA THOMAS
权利人:SYNGENTA PARTICIPATIONS AG; SYNGENTA LTD
摘要:The present invention provides stereoselective processes for the preparation of compounds of formula (I) n n n n n n n n n n n n wherein n P is phenyl, naphthyl, a 6-membered heteroaryl group containing one or two nitrogen atoms as ring members, or a 10-membered bicyclic heteroaryl group containing one or two nitrogen atoms as ring members, and wherein the phenyl, naphthyl and heteroaryl groups are optionally substituted; n R 1 is chlorodifluoromethyl or trifluoromethyl; n R 2 is optionally substituted aryl or optionally substituted heteroaryl; n n is 0 or 1; n including the process comprising n (a-i) reacting a compound of formula II n n n n n n n n n n n n n n n n wherein P, R 1 and R 2 are as defined for the compound of formula I; n with nitromethane in the presence a chiral catalyst to give a compound of formula III n n n n n n n n n n n n n n n n wherein P, R 1 and R 2 are as defined for the compound of formula I; and n (a-ii) reductively cyclising the compound of formula III to give the compound of formula I. n n n n n The invention also provides intermediates useful for processes for the synthesis of compounds of formula (I).

专利号:US-8003831-B1
优先权日:2007-12-18
标 题:Process for the synthesis of dihalodinitrobenzenes
发明人：RITTER JOACHIM C
权利人:DU PONT
摘要:A process is provided for the preparation of 1,3-dihalo-4,6-dinitrobenzene by the nitration of 1,3-dihalobenzene. The direct isolation of highly pure 1,3-dihalo-4,6-dinitrobenzene is accomplished without a water or ice quench, and involves the use of at least one equivalent of SO 3 during the reaction, slow crystallization, and isolation of product from a cold crystal slurry.