CAS: 114-49-8; Scopolamine Hydrobromide

该化合物是一种来自索拉塞埃家族植物,特别是来自贝勒多纳工厂的三氯丁二烯藻类;一种在水和酒精中溶解的白到白的结晶粉,可溶于水和酒精,适合各种药物配方;该物质主要作为一种抗胆碱剂作用,阻断...

结构式图片

欧盟法规

REACH注册ECHA物质ECHA物质C&L通报REACH预注册

上下游产品

CAS号24676-80-0 Norscopolamine ... | CAS号30286-75-0 氧托溴铵 | CAS号55869-99-3 山莨菪碱 | CAS号126371-43-5 (-)-Anisodamine | CAS号101-31-5 天仙子胺 | CAS号4684-28-0 去甲东莨菪碱

合成工艺路线路线简述

    9-Methyl-3-Oxa-9-Azatricyclo[3.3.1.0(2,4)]Non-7-Yl-3'-(Acetyloxy)-2'-Phenyl Propanoate置于盐酸,氢溴酸体系中,用 水,乙醇 用作溶剂,以15.4 G的收率获得东莨菪碱氢溴酸盐
    参考文献:Cn116731007
    标题:Cn116731007

    海关参考信息

    专利信息


    专利号:WO-9217496-A1
    优先权日:1991-03-18
    标题 :Isolation and sequence of the acetyl coa:deacetylcephalosporin acetyltransferase gene
    发明人:MATHISON LORILEE; SOLIDAY CHARLES L; RAMBOSEK JOHN A
    权利人:PANLABS INC
    摘要:The invention relates to a DNA sequence with a nucleotide sequence encoding a polypeptide in a host cell having Cephalosporin C synthetase (DAC acetyltransferase) activity which is the last enzyme in the synthesis of cephalosporins. Embodiments of the invention relate to methods and compositions for detecting the gene or its product, mutants and hybrids of the gene, replicative cloning and expression vectors, and processes for preparing recombinant DAC acetyltransferase polypeptide useful for host cell synthesis of, as well as cell-free synthesis of natural and synthetic cephalosporin antibiotics.

    专利号:US-2010105111-A1
    优先权日:2007-02-28
    标 题 :Method for production of optically active amino acid
    发明人:ASANO YASUHISA; TANAKA AKINORI; HASEMI RYUJI
    权利人:MITSUBISHI GAS CHEMICAL CO
    摘要:An optically active amino acid is useful as food or feed, agrochemicals, chemical products for industrial use, intermediates for synthesis of cosmetics or medicines and the like and is also important as optical resolving agents or chiral building blocks for use in organic synthesis. Thus, the object is to provide an industrially practical method for producing the optically active amino acid simply and at low cost. The method comprises the step of reacting an aminonitrile composed of a mixture of a D-aminonitrile and an L-aminonitrile with a biocatalyst which is one derived from a newly isolated microorganism belonging to the genus Rhodococcus and has an activity of converting the two aminonitriles into a D-amino acid amide and an L-amino acid amide respectively, a biocatalyst which has an activity of racemizing the D-amino acid amide and the L-amino acid amide to each other, and a biocatalyst which has an activity of converting one of the D-amino acid amide and the L-amino acid amide into the corresponding D- or L-amino acid.

    专利号:US-2008300418-A1
    优先权日:2004-11-08
    标 题:Synthesis of Cardiolipin Analogues and Uses Thereof
    发明人:AHMAD MOGHIS U; UKKALAM MURALI K; ALI SHOUKATH M; AHMAD IMRAN
    权利人:AHMAD MOGHIS U; UKKALAM MURALI K; ALI SHOUKATH M; AHMAD IMRAN
    摘要:The invention provides novel synthetic methodologies for preparing cardiolipin, migrated caridiolipin (1,2-positional isomer of cardiolipin) and their analogues having varying fatty acids and/or alkyl chains with varying length and degrees of saturation/unsaturation. The method comprises (a) reacting an optically pure 1,2-O-dialkyl-sn-glycerol or 1,2-O-dialkyl-sn-glycerol with one or more phosphoramidite reagent(s), wherein a phosphite triester is produced; (b) coupling the product of (a) with glycerol, wherein a protected cardiolipin is produced; and (c) deprotecting the protected cardiolipin, such that cardiolipin is prepared. The cardiolipins and analogues thereof, prepared by the present methods, can be incorporated into liposomes, which can also include active agents such as hydrophobic or hydrophilic drugs, antisense nucleotides or diagnostic agents. Such liposomes can be used to treat diseases or can be used in diagnostic and/or analytical assays.

    专利号:US-6350612-B1
    优先权日:1986-01-28
    标 题 :Isolation and expression of DNA sequence encoding the five subunits of Bordetella pertussis toxin
    发明人:RAPPUOLI RINO; NICOSIA ALFREDO; ARICO MARIA BEATRICE
    权利人:CHIRON SPA
    摘要:Cloning and sequencing of the Eco RI fragment of B. pertussis chromosomal DNA with 4696 base pairs, containing the genes which code for the five subunits of the pertussis toxin. A hybrid plasmid containing the DNA fragment or its further fragments and a micro-organism transformed by the hybrid plasmid and capable of expressing the cloned DNA fragment or further fragments thereof by synthesis of the pertussis toxin or one or more subunits of the pertussis toxin. The pertussis toxin or one or more subunits of the pertussis toxin so obtained are useful for the preparation of vaccines and diagnostic kits.

    专利号:US-9757463-B2
    优先权日:2012-06-15
    标题 :Linear polyester and semi-linear glycidol polymer systems: formulation and synthesis of novel monomers and macromolecular structures
    发明人:HARTH EVA M; BEEZER DAIN B; LI GUANGZHAO; SPEARS BENJAMIN R; STEVENS DAVID M
    权利人:UNIV VANDERBILT
    摘要:Disclosed herein are glycidol-based polymers, nanoparticles, and methods related thereto useful for drug delivery. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

    专利号:US-2006078560-A1
    优先权日:2003-06-23
    标 题 :Method of inducing apoptosis and inhibiting cardiolipin synthesis
    发明人:JAMIL HARIS; AHMAD MOGHIS U; AHMAD IMRAN
    权利人:NEOPHARM INC
    摘要:The present invention provides a method for inducing apoptosis within a cell by exposing the cell to an inhibitor of cardiolipin synthesis under conditions sufficient to induce apoptosis within the cell. The method can be used to investigate or treat disorders such as cancer, obesity, and cardiovascular disorders. The invention also provides a pharmaceutical composition including an inhibitor of cardiolipin synthesis and a liposomal carrier.
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    主要参考文献


    1: Zhang YL, Li YP. [Simultaneous determination of scopolamine hydrobromide, atropine sulfate, ephedrine hydrochloride and pseudoephedrine hydrochloride in Zhichuanling oral liquid with HPLC]. Zhongguo Zhong Yao Za Zhi. 2013 Oct;38(19):3291-4. Chinese. Chinese. doi: 10.2147/IJN.S17900. Epub 2011 Apr 28.
    4: Martin-Flores M, Mercure-McKenzie TM, Campoy L, Erb HN, Ludders JW, Gleed RD. Controlled retrospective study of the effects of eyedrops containing phenylephrine hydrochloride and scopolamine hydrobromide on mean arterial blood pressure in anesthetized dogs. Am J Vet Res. 2010 Dec;71(12):1407-12. doi: 10.2460/ajvr.71.12.1407. Chinese. doi: 10.1007/s00508-008-1094-2. German. Japanese. Pharmazie. 1983 Aug;38(8):520-3. German.

    合成参考文献


    摘要:Archives Internationales de Pharmacodynamie et de Therapie., 137(375), 1962 []
    摘要:Archives Internationales de Pharmacodynamie et de Therapie., 180(155), 1969 []
    摘要:Journal of Pharmacology and Experimental Therapeutics., 79(127), 1943
    参考文献:10.1007/bf02246352
    摘要:Terranova JP, Storme JJ, Lafon N, Péŕio A, Rinaldi-Carmona M, Le Fur G, Soubrié P. Improvement of memory in rodents by the selective CB1 cannabinoid receptor antagonist, SR 141716. Psychopharmacology (Berl). 1996 Jul;126(2):165–72. doi: 10.1007/bf02246352.
    参考文献:10.1007/bf02247383
    摘要:Meziane H, Mathis C, Paul SM, Ungerer A. The neurosteroid pregnenolone sulfate reduces learning deficits induced by scopolamine and has promnestic effects in mice performing an appetitive learning task. Psychopharmacology (Berl). 1996 Aug;126(4):323–30. doi: 10.1007/bf02247383.
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