专利号:US-6180830-B1 优先权日:1995-11-08 标题 :Method for preparing a bimetallic ruthenium/tin catalyst and a process for the synthesis of aldehydes 发明人:JACQUOT ROLAND 权利人:RHODIA CHIMIE SA 摘要:The present invention relates to a new process for the preparation of a bimetallic ruthenium/tin catalyst. The process for the preparation of a bimetallic ruthenium/tin catalyst according to the invention is characterised by the fact that it consists in carrying out the reduction of a ruthenium complex having an electrovalency of -4 and a coordination number of 6, the ligands being either a halogen atom or an anion or a tin halide. The catalyst is further employed for the preparation of aldehydes by reduction, in the vapor phase, of carboxylic acids, esters and anhydrides.
专利号:US-4143050-A 优先权日:1977-01-05 标题 :Manufacture of 3-halosulfonylthiophene-carboxylic acid compounds 发明人:ROSSY PHILLIP A; HOFFMANN WERNER; MUELLER NORBERT 权利人:BASF AG 摘要:3-Halosulfonylthiophene-carboxylic acid compounds are manufactured by reacting 3-ketothiophane-carboxylic acid compounds with sulfonic acid compounds, reacting the end product from the 1st reaction stage with alkali metal polysulfides, reacting the end product from the 2nd stage with a dehydrogenating agent and finally reacting the end product from the 3rd stage with halogen and water. The products are starting compounds for the manufacture of drugs, dyes and crop protection agents and have an anti-inflammatory, analgesic and anti-rheumatic action. In particular, the end products I are starting materials for the manufacture of sweeteners which are non-toxic and free from an after-taste, flavor-improving agents, diabetic aids and feedstuffs, and provide the means of a simple and economical synthesis of thiophene-saccharins.
专利号:US-5476827-A 优先权日:1991-10-24 标题 :Process for the synthesis of aldehydes and their derivatives and catalyst for use thereof 发明人:FERRERO ROSE-MARIE; JACQUOT ROLAND 权利人:RHONE POULENC CHIMIE 摘要:A process for the preparation of aldehydes by hydrogen reduction of carboxylic acids, esters or anhydrides, characterized in that the reduction conducted in the vapor phase, in the presence of a bimetallic catalyst of the ruthenium/tin type.
专利号:US-9676783-B2 优先权日:2008-10-22 标 题:Method of treatment using substituted pyrazolo[1,5-A] pyrimidine compounds 发明人:HAAS JULIA; ANDREWS STEVEN W; JIANG YUTONG; ZHANG GAN 权利人:ARRAY BIOPHARMA INC 摘要:Compounds useful in the synthesis of compounds for treating pain, cancer, inflammation, neurodegenerative disease or Typanosoma cruzi infection in a mammal.
专利号:US-10995078-B2 优先权日:2013-03-13 标 题:Compounds and compositions for inhibition of FASN 发明人:BAIR KENNETH W; LANCIA JR DAVID R; LI HONGBIN; LOCH JAMES; LU WEI; MARTIN MATTHEW W; MILLAN DAVID S; SCHILLER SHAWN E R; TEBBE MARK J 权利人:FORMA THERAPEUTICS INC 摘要:The present invention relates to compounds and composition for inhibition of FASN, their synthesis, applications, and antidotes. An illustrative compound of the invention is shown below:
专利号:US-11299484-B2 优先权日:2018-10-10 标 题 :Inhibiting fatty acid synthase (FASN) 发明人:MARTIN MATTHEW W; ZABLOCKI MARY-MARGARET; MENTE SCOT; DINSMORE CHRISTOPHER; WANG ZHONGGUO; ZHENG XIAOZHANG 权利人:FORMA THERAPEUTICS INC 摘要:The present disclosure is directed to inhibitors of FASN. The compounds can be useful in the treatment of disease or disorders associated with the inhibition of FASN. For instance, the disclosure is concerned with compounds and compositions for inhibition of FASN, methods of treating, preventing, or ameliorating diseases or disorders associated with the inhibition of FASN, and methods of synthesis of these compounds.