CAS: 2201-23-2; 1-Phenylcyclohexanecarbonitrile

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CAS号766-05-2 环己甲腈 | CAS号108-90-7 氯苯 | CAS号108-86-1 溴苯 | CAS号7677-24-9 三甲基氰硅烷 | CAS号1589-60-2 1-苯基环己醇 | CAS号771-98-2 1-苯基-1-环己烯 | CAS号111-24-0 1,5-二溴戊烷 | CAS号140-29-4 苯乙腈 | CAS号712-50-5 环己基苯基酮 | CAS号2890-60-0 1-phenylcyclohe... | CAS号2890-42-8 1-苯基环己烷羰酰氯 | CAS号1135-67-7 1-苯基环己烷羧酸 | CAS号17380-78-8 1-苯基-1-环己烷羧酸甲酯 | CAS号17380-54-0 C-(1-苯基环己基)-甲胺 | CAS号2201-24-3 1-苯基环己基胺盐酸盐 | CAS号68692-77-3 (1-phenylcycloh... | CAS号41848-75-3 phenyl-(1-pheny...

1-氰基环己烷羧酸乙酯置于bis(η3-Allyl-μ-Chloropalladium(II)),Potassium Tert-Butylate,4,5-双二苯基膦-9,9-二甲基氧杂蒽体系中,用 乙醇,水,均三甲苯 用作溶剂,化学反应 10.17H,反应生成1-苯基-1-环己基甲腈
参考文献:钯乙酸盐与芳基卤化物和三氟甲磺酸酯的钯催化脱羧偶联合成α-芳基腈
标题:钯乙酸盐与芳基卤化物和三氟甲磺酸酯的钯催化脱羧偶联合成α-芳基腈
摘要:值得其盐:描述了氰基乙酸盐及其与芳基氯化物,溴化物和三氟甲磺酸酯的钯催化的脱羧偶联反应(参见方案).该反应对于制备各种α-芳基腈具有潜在的实用性,并具有非常好的官能团耐受性.S-Phos = 2-((2,6-二甲氧基联苯)二环己基膦),Xant-Phos = 4,5-双(二苯基膦基)-9,9-二甲基x吨.
Doi:10.1002/anie.201006763

专利信息

专利号:WO-9857632-A1
优先权日:1997-06-18
标题 :ALPHA 1a ADRENERGIC RECEPTOR ANTAGONISTS
发明人：PATANE MICHAEL A; BOCK MARK G; NAGARATHNAM DHANAPALAN; LAGU BHARAT; WONG WAI C
权利人:MERCK & CO INC; SYNAPTIC PHARMA CORP; PATANE MICHAEL A; BOCK MARK G; NAGARATHNAM DHANAPALAN; LAGU BHARAT; WONG WAI C
摘要:This invention relates to certain novel compounds and derivatives thereof, their synthesis, and their use as alpha 1a adrenergic receptor antagonists. One application of these compounds is in the treatment of benign prostatic hyperplasia. These compounds are selective in their ability to relax smooth muscle tissue enriched in the alpha 1a receptor subtype without at the same time inducing hypotension. One such tissue is found surrounding the urethral lining. Therefore, one utility of the instant compounds is to provide acute relief to males suffering from benign prostatic hyperplasia, by permitting less hindered urine flow. Another utility of the instant compounds is provided by combination with a human 5-alpha reductase inhibitory compound, such that both acute and chronic relief from the effects of benign prostatic hyperplasia are achieved.

专利号:US-9868718-B2
优先权日:2006-01-06
标 题 :Cycloalkylamines as monoamine reuptake inhibitors
发明人：SHAO LIMING; WANG FENGJIANG; MALCOLM SCOTT CHRISTOPHER; HEWITT MICHAEL CHARLES; BUSH LARRY R; MA JIANGUO; VARNEY MARK A; CAMPBELL UNA; ENGEL SHARON RAE; HARDY LARRY WENDELL; KOCH PATRICK; CAMPBELL JOHN E
权利人:SUNOVION PHARMACEUTICALS INC
摘要:The invention relates to novel cyclohexylamine derivatives and their use in the treatment and/or prevention of central nervous system (CNS) disorders, such as depression, anxiety, schizophrenia and sleep disorder as well as methods for their synthesis. The invention also relates to pharmaceutical compositions containing the compounds of the invention, as well as methods of inhibiting reuptake of endogenous monoamines, such as dopamine, serotonin and norepinephrine from the synaptic cleft and methods of modulating one or more monoamine transporter.

专利号:US-6339090-B1
优先权日:1998-07-30
标题:Alpha 1A adrenergic receptor antagonists
发明人：BARROW JAMES C; SELNICK HAROLD G; NANTERMET PHILIPPE G
权利人:MERCK & CO INC
摘要:This invention relates to certain novel compounds and derivatives thereof, their synthesis, and their use as alpha 1a adrenergic receptor antagonists. One application of these compounds is in the treatment of benign prostatic hyperplasia. These compounds are selective in their ability to relax smooth muscle tissue enriched in the alpha 1a receptor subtype without at the same time inducing hypotension. One such tissue is found surrounding the urethral lining. Therefore, one utility of the instant compounds is to provide acute relief to males suffering from benign prostatic hyperplasia, by permitting less hindered urine flow. Another utility of the instant compounds is provided by combination with a human 5-alpha reductase inhibitory compound, such that both acute and chronic relief from the effects of benign prostatic hyperplasia are achieved.

专利号:CN-117623882-A
优先权日:2023-11-20
标 题:A simple and efficient method for the synthesis and preparation of column[6]arenes