CAS: 2362-12-1; 4-Bromo-2-Methylphenol

上下游产品

CAS号14804-31-0 4-溴-2-甲基苯甲醚 | CAS号95-48-7 邻甲酚 | CAS号583-75-5 4-溴-2-甲基苯胺 | CAS号2316-64-5 5-溴-2-羟基苯甲醇 | CAS号917-54-4 甲基锂 | CAS号118-79-6 三溴苯酚 | CAS号24106-05-6 4'-溴-2'-甲基乙酰苯胺 | CAS号56-23-5 四氯化碳 | CAS号3816-66-8 3-羟基-4-甲基苯腈 | CAS号32281-01-9 4-羟基-3-甲基苯硫酚 | CAS号452-72-2 4-氟-2-甲基苯酚 | CAS号4186-54-3 α,3,5-三溴-2-羟基甲苯 | CAS号20294-50-2 4-溴-2-甲基-6-硝基苯酚 | CAS号24224-30-4 3-甲基-9H-咔唑-2-醇 | CAS号30451-49-1 3-甲基-[1,1'-联苯]-4-醇 | CAS号2219-82-1 2-叔丁基-6-甲基苯酚 | CAS号338454-30-1 4-苄氧基-3-甲基苯硼酸 | CAS号95-71-6 鹿蹄草素

邻甲酚置于n-溴代丁二酰亚胺(Nbs),2C5Hn10(3-)*2Mn(2+)*cu(2+)*5H2O体系中,用 乙腈 用作溶剂,化学反应 6.0H,以94%的收率获得4-溴-2-甲基苯酚
参考文献:配位聚合物负载单点cu(II)催化剂的定向结构转变,以控制ch卤化位点的选择性
标题:配位聚合物负载单点cu(II)催化剂的定向结构转变,以控制ch卤化位点的选择性
摘要:C-h键功能化的主要困难是在发生反应的地方准确地控制催化剂.在这项工作中,为了获得高效和区域选择性的单中心催化剂,{[mn(hidbt)dmf].h 2 O} N(1)[h 3 Idbt = 5的三维(3D)菱形骨架构造了含有配位dmf分子的,5'-(1 H-咪唑-4,5-二基)-双(2 H-四唑)].对于溶解-再结晶的结构转变过程,有吸引力的结构转变从1到新的晶体形式为{[mn 3(idbt)2(h 2O)2 ].3H 2 O} N(2)具有3D窗口状结构,然后可以通过阳离子交换以单晶至单晶的方式将2中的mn离子与cu离子交换,从而生成cu-交换产物{[mn 2 Cu(idbt)2(h 2 O)2 ].3H 2 O} N(2A),其窗口状骨架类似于2.此外,2和2A用作非均相催化剂,用于苯酚与n的区域选择性c-h卤化-卤代琥珀酰亚胺(ncs和nbs)来生产定点选择性单卤代产物.发现2A的
Doi:10.1021/acs.Inorgchem.9B01891

专利信息

专利号:US-8513465-B2
优先权日:2008-02-04
标题:Potassium organotrifluoroborate derivative and a production method therefor
发明人：KANG HEONJOONG; HAM JUNGYEOB; AHN HONG RYUL; PARK YOUNG HEE
权利人:KANG HEONJOONG; HAM JUNGYEOB; AHN HONG RYUL; PARK YOUNG HEE; SNU R&DB FOUNDATION
摘要:Provided are a production method for a potassium organotrifluoroborate compound having a hydroxyl group, and a novel potassium organotrifluoroborate compound having a hydroxyl group. The production method is advantageous in that a potassium organotrifluoroborate compound can be produced in a single reaction without recourse to a process of isolating and purifying an intermediate. The novel potassium organotrifluoroborate compound having a hydroxyl group is useful as a reactant which is widely used in the total synthesis of physiologically active natural products and diverse organic synthesis reactions including halogen substitution reactions, 1,2- and 1,4-addition reactions using a rhodium (Rh) catalyst, and Suzuki coupling reactions using a palladium (Pd) catalyst.

专利号:US-5116987-A
优先权日:1988-12-26
标题:Method of preparing chroman derivatives, and synthesis intermediates
发明人：GARCIA GEORGES; METTEFEU DANIEL; ROUX RICHARD
权利人:SANOFI SA
摘要:The invention describes a method of synthesizing a compound of the formula ##STR1## in which X=O or NR, n Z=an electron-attracting group, n R=H, CN or NO 2 , n R 1 +R 2 +N--Câ•?X=a 5-membered or 6-membered heterocycle, and n R 3 =H, R 4 =OH or R 3 +R 4 =a bond, n said method involving intermediates of the formula ##STR2## in which R 5 =H, Br or N(R 1 )CXR 2 . This method of synthesis does not involve the epoxide derivative of the chroman. n The novel compounds of formula (IX) form a further subject of the invention.

专利号:US-9994558-B2
优先权日:2013-09-20
标题 :Multicyclic compounds and methods of using same
发明人：BALOGLU ERKAN; SHACHAM SHARON; SENAPEDIS WILLIAM; MCCAULEY DILARA; LANDESMAN YOSEF; GOLAN GALI; KALID ORI; SHECHTER SHARON
权利人:KARYOPHARM THERAPEUTICS INC
摘要:The invention generally relates to compounds represented by Structural Formula I: or a pharmaceutically acceptable salt thereof, wherein the variables are as defined and described herein. The invention also includes the synthesis and use of a compound of structural formula I, or a pharmaceutically acceptable salt or composition thereof, e.g., in treatment of cancer (e.g., mantle cell lymphoma), and other diseases and disorders (e.g., PAK-mediated, for example, PAK4-mediated, diseases and disorders).

专利号:US-9505799-B2
优先权日:2011-05-13
标题:18F-labeled precursor of PET radioactive medical supplies, and preparation method thereof
发明人：CHI DAE-YOON; LEE BYOUNG-SE; PARK CHANSOO; LEE MIN-HYUNG; CHA HYOJIN; CHO WOOJIN; KANG HEEWON; KIM KYUNGHUN
权利人:CHI DAE-YOON; LEE BYOUNG-SE; PARK CHANSOO; LEE MIN-HYUNG; CHA HYOJIN; CHO WOOJIN; KANG HEEWON; KIM KYUNGHUN; FUTURECHEM CO LTD
摘要:The present invention relates to a precursor of positron emission tomography (PET) radioactive medical supplies, a preparation method thereof, and an application thereof, and more specifically, to a precursor having a tetravalent organic salt leaving group, a preparation method, and a method for preparing desired PET radioactive medical supplies in a high radiochemical yield within a short preparation time by introducing 18 F using the same through a single step. The precursor having a tetravalent organic salt leaving group of the present invention can simplify the known complex multistep preparation of radioactive medical supplies into a single step, can save production costs because an excessive amount of a phase transfer catalyst is not required, facilitates separation of a compound after reaction, and enables rapid reaction velocity. The features are appropriate for the mass production of PET radioactive medical supplies by an automated synthesis system.

专利号:US-9938258-B2
优先权日:2012-11-29
标 题:Substituted 2,3-dihydrobenzofuranyl compounds and uses thereof
发明人：BALOGLU ERKAN; SHECHTER SHARON; SHACHAM SHARON; MCCAULEY DILARA; SENAPEDIS WILLIAM; GOLAN GALI; KALID ORI
权利人:KARYOPHARM THERAPEUTICS INC
摘要:The invention generally relates to substituted 2,3-dihydrobenzofuranyl compounds, and more particularly to a compound represented by Structural Formula I: n nor a pharmaceutically acceptable salt thereof, wherein the variables are as defined and described herein. The invention also includes the synthesis and use of a compound of Structural Formula I, or a pharmaceutically acceptable salt or composition thereof, e.g., in the treatment of cancer (e.g., mantle cell lymphoma), and other diseases and disorders.

专利号:CN-113797212-B
优先权日:2020-06-11
标 题:Synthesis method and activity study of a group of antibacterial drugs containing mannose structure