CAS: 34701-33-2; (R)-3-Methyl-2-Butylamine

上下游产品

1,2-甲基丙胺 2-Amino-3-Methylbutane 598-74-3
L-缬氨醇 (S)-Valinol 2026-48-4

3-甲基-2-丁醇置于alcohol Dehydrogenase From Streptomyces Coelicolor,Leucine Dehydrogenase From Exiguobactertium Sibiricum K77S/n270L Double Mutant,还原型辅酶ⅰ体系中,用 Aq. Buffer 用作溶剂,化学反应 24.0H,以93%的收率获得(R)-(-)-3-甲基-2-丁胺
参考文献:使用氧化还原中性双酶级联反应对仲醇进行不对称胺化反应
标题:使用氧化还原中性双酶级联反应对仲醇进行不对称胺化反应
摘要:需要从简单的非手性化合物合成光学纯分子的多酶级联方法.在此,通过使用醇脱氢酶和新开发的胺脱氢酶成功构建了外消旋仲醇不对称胺化为相应手性胺的辅因子自足级联方案.两种酶的相容性和相同的辅因子依赖性导致在单罐合成中形成了巧妙的原位辅因子回收系统.人工氧化还原-中性级联过程使外消旋仲醇转化为对映体纯胺,具有相当大的转化率(高达94%),对映体过量超过99%,而仅以氨为代价.
Doi:10.1002/cctc.201500785

专利信息

专利号:US-8084630-B2
优先权日:2007-05-31
标 题 :Process for the synthesis of ramelteon and its intermediates
发明人：KANSAL VINOD KUMAR; MISTRY DHIRENKUMAR N; VASOYA SANJAY L; RAFILOVICH MICHAL; MOHA-LERMAN ELENA BEN; LIFSHITZ-LIRON REVITAL
权利人:KANSAL VINOD KUMAR; MISTRY DHIRENKUMAR N; VASOYA SANJAY L; RAFILOVICH MICHAL; MOHA-LERMAN ELENA BEN; LIFSHITZ-LIRON REVITAL; TEVA PHARMA
摘要:The present invention provides processes and intermediates for the synthesis of ramelteon.

专利号:US-6448058-B1
优先权日:1997-09-12
标 题:Methods for solid phase synthesis of mercapto compounds and derivatives, combinatorial libraries thereof and compositions obtained thereby
发明人：PATEL DINESH V; NGU KHEHYONG; ZHOU JIANPING
权利人:VERSICOR INC
摘要:Methods of preparing combinatorial libraries of mercapto (thiol) compounds them and compositions obtained therefrom are disclosed. The compounds are synthesized on a solid support. Following synthesis, the compounds are optionally cleaved from the support. One such method of synthesis involves attack of an S-protected nucleophile on a resin functionalized with a leaving group. The invention also provides for screening the mercapto compounds for bioactive compounds; in particular, for inhibitors of MMPs.

专利号:US-2009281176-A1
优先权日:2007-11-01
标题:Process for the synthesis of ramelteon and its intermediates
发明人：KANSAL VINOD KUMAR; MISTRY DHIRENKUMAR N; VASOYA SANJAY L; PATEL RAKESH; JADAV ARPAN M
权利人:KANSAL VINOD KUMAR; MISTRY DHIRENKUMAR N; VASOYA SANJAY L; PATEL RAKESH; JADAV ARPAN M
摘要:A process for the preparation of ramelteon and intermediates useful in the process. The process suitable for industrial scale provides increased yield and/or greater purity with fewer process steps.

专利号:WO-2009056993-A2
优先权日:2007-11-01
标题 :A process for the synthesis of ramelteon and its intermediates

专利号:US-2009069581-A1
优先权日:2007-05-31
标题:Process for the synthesis of ramelteon and its intermediates

专利号:EP-2098519-A1
优先权日:2007-05-31
标 题 :Process for the synthesis of ramelteon and its intermediates