CAS: 452-08-4; 2-Bromo-4-Fluoro-1-Methoxybenzene

上下游产品

CAS号496-69-5 2-溴-4-氟苯酚 | CAS号74-88-4 碘甲烷 | CAS号459-60-9 4-氟苯甲醚 | CAS号1978-39-8 5-氟-2-甲氧基苯胺 | CAS号445-83-0 4-氟-2-硝基苯甲醚 | CAS号496-69-5 2-溴-4-氟苯酚 | CAS号426831-32-5 5-氟-2-甲氧基苄醇 | CAS号1441770-44-0 4-(5-fluoro-2-m... | CAS号179897-92-8 2-溴-4-氟-6-硝基苯甲醚 | CAS号189628-38-4 5-氟-2-甲氧基苯腈 | CAS号188132-02-7 5-氟-2-甲氧苯基溴化镁 | CAS号72955-97-6 5-氟-2-甲氧基苯酚 | CAS号19415-51-1 5-氟-2-甲氧基苯甲醛

对氟苯甲醚置于(Ch3)4Br体系中,用 Liquid Sulphur Dioxide 作为反应溶剂,以100%的收率获得产物2-溴-4-氟苯甲醚
参考文献:替代亲电香体丹酸酐硫代液.茴香单丁醚替代物的练习曲.过渡与过渡时期的电子通讯
标题:替代亲电香体丹酸酐硫代液.茴香单丁醚替代物的练习曲.过渡与过渡时期的电子通讯
摘要:由苯胺在液体so 2中的溴化速率常数确定的十一种取代衍生物的反应结构相关性,与在水中观测到的不同,表明该反应对取代基效应高度敏感(ρ= −7.1;ρ= −10.51).该结果归因于甲氧基的溶剂化,与邻位取代的衍生物(ρ=-8.86)相比,其降低了对位取代的共轭(ρ=-9.70).高度溶剂化的过渡态在反应坐标上与反应物相距甚远,在此状态下产生的正电荷几乎为1.
DOI:10.1002/hlca.19830660410

专利信息

专利号:US-2006089405-A1
优先权日:2004-10-21
标 题 :Asymmetric synthesis of dihydrobenzofuran derivatives
发明人：ZHOU DAHUI; STACK GARY P; GONTCHAROV ALEXANDER V
权利人:WYETH CORP
摘要:This invention concerns a process for the preparation of benzofuran derivatives. In some aspects, these compounds are of formula I: n n nwherein each of R 1 , R 2 , R 3 , and R 4 is as defined herein.

专利号:US-7884125-B2
优先权日:2008-04-30
标 题:Straightforward entry to 7-azabicyclo[2.2.1]heptane-1-carbonitriles and subsequent synthesis of epibatidine analogues
发明人：STEVENS CHRISTIAN; HEUGEBAERT THOMAS
权利人:UNIV GENT
摘要:The present invention relates to a group of substituted-7-azabicyclo-[2.2.1]heptyl derivatives with biological activity. The present invention also relates to synthetic methods for producing said substituted-7-azabicyclo-[2.2.1]heptyl derivatives. The present invention also relates to certain intermediates for producing such substituted-7-azabicyclo-[2.2.1]heptyl derivatives, as well as a synthetic method for producing such intermediates. The present invention also relates to pharmaceutical compositions comprising such substituted-7-azabicyclo-[2.2.1]heptyl derivatives, as well as their use as medicaments for the treatment of diseases mediated by a Nicotinic Acetylcholine Receptor or a receptor being a member of the Neurotransmitter-gated Ion Channel Superfamily, such as pain, Alzheimer's disease, Parkinson's disease, schizophrenia, epilepsy and nicotine addiction.

专利号:US-9676783-B2
优先权日:2008-10-22
标 题:Method of treatment using substituted pyrazolo[1,5-A] pyrimidine compounds
发明人：HAAS JULIA; ANDREWS STEVEN W; JIANG YUTONG; ZHANG GAN
权利人:ARRAY BIOPHARMA INC
摘要:Compounds useful in the synthesis of compounds for treating pain, cancer, inflammation, neurodegenerative disease or Typanosoma cruzi infection in a mammal.

专利号:AU-2005299757-A1
优先权日:2004-10-21
标 题:Asymmetric synthesis of dihydrobenzofuran derivatives

专利号:US-2009275616-A1
优先权日:2008-04-30
标 题 :Straightforward entry to 7-azabicyclo[2.2.1]heptane-1-carbonitriles and subsequent synthesis of epibatidine analogues

专利号:CA-2584775-A1
优先权日:2004-10-21
标题:Asymmetric synthesis of dihydrobenzofuran derivatives