CAS: 452-69-7; 4-Fluoro-3-Methylaniline

上下游产品

CAS号455-88-9 2-氟-5-硝基甲苯 | CAS号125620-28-2 Pd-C | CAS号99-08-1 3-硝基甲苯 | CAS号331-30-6 N-(4-bromo-3-me... | CAS号394-30-9 5-氯-2-氟苯甲酸 | CAS号452-68-6 2-氟-5-碘甲苯 | CAS号452-66-4 5-氯-2-氟甲苯 | CAS号97389-11-2 4-氟-5-甲基邻苯二胺 | CAS号97389-10-1 4-氟-5-甲基-2-硝基苯胺 | CAS号629672-19-1 4-氟-3-甲基苯磺酰氯 | CAS号749240-54-8 5-氟-6-甲基靛红 | CAS号757982-25-5 4-methyl-5-fluo... | CAS号67531-80-0 1-fluoro-4-(4-m... | CAS号97389-17-8 3,4,7-trimethyl...

2-氟-5-硝基甲苯置于一水合肼体系中,用 乙醇 作为反应溶剂,化学反应 12.0H,以97%的收率获得产物4-氟-3-甲基苯胺
参考文献:Feo(Oh)@c催化对硝基芳基氟化物的选择性肼取代及其在酞嗪酮合成中的应用
标题:Feo(Oh)@c催化对硝基芳基氟化物的选择性肼取代及其在酞嗪酮合成中的应用
摘要:描述了 Feo(Oh)@c 纳米粒子催化的水合肼对对硝基芳基氟化物的有效肼取代.带有吸电子基团的对硝基芳基氟化物的肼取代以高产率和选择性有效地进行.相应的产品可用于合成二氮杂萘酮,这是一种具有药用价值的物质.
DOI:10.1002/open.202200023

专利信息

专利号:US-7579487-B2
优先权日:2004-05-11
标 题 :Process for making N-sulfonated-amino acid derivatives
发明人：DREHER SPENCER D; IKEMOTO NORIHIRO; SHULTZ C SCOTT; WILLIAMS J MICHAEL
权利人:MERCK & CO INC
摘要:This invention relates to a process for preparing optically active α-amino acid substrates which are used to make potent lethal factor (LF) inhibitors for the treatment of anthrax. This invention further relates to a process for synthesis of potent LF-inhibitors for the treatment of anthrax. Specifically, the invention concerns a novel, high-yielding and highly enantioselective asymmetric hydrogenation reaction of a tetrasubstituted ene-sulfonamide acid or ester.

专利号:US-5998595-A
优先权日:1996-11-05
标题:Azidohalogenobenzyl derivatives, sugar compounds and protection of hydroxy groups
发明人：KUSUMOTO SHOICHI; FUKASE KOICHI
权利人:WAKO PURE CHEM IND LTD
摘要:Azidohalogenobenzyl derivatives of the formula (I) ##STR1## wherein A is a halogen atom, B is a halogen atom or a hydrogen atom, and X is a group reactive with a hydroxy group, methods of protecting hydroxy group(s) using said derivatives, and sugar compounds wherein a hydrogen atom of at least one hydroxy group is substituted by an azidohalogenobenzyl group. According to the present invention, there are provided novel derivatives capable of introducing a group into a compound having hydroxy group(s), which group is useful as a stable hydroxy-protecting group even in solid phase synthesis for the purpose of the extension of sugar chain under continuous acidic conditions and of being removed under mild conditions; sugar compounds protected by using said derivatives; and methods of protecting hydroxy group(s) using said derivatives.

专利号:US-2005026965-A1
优先权日:2000-12-29
标 题 :Pharmaceutical uses and synthesis of nicotinanilide-N-oxides

专利号:US-2003004189-A1
优先权日:2000-12-29
标 题 :Pharmaceutical uses and synthesis of nicotinanilide-N-oxides

专利号:US-2010063105-A1
优先权日:2000-12-29
标题 :Pharmaceutical uses and synthesis of nicotinanilide-n-oxides

专利号:US-7141590-B2
优先权日:2000-12-29
标题 :Pharmaceutical uses and synthesis of nicotinanilide-N-oxides
发明人：CUTSHALL NEIL S; YAGER KRAIG M
权利人:UCB SA
摘要:Disclosed are nicotinanilide-N-oxide compounds, methods for their production, pharmaceutical compositions which include these compounds, and methods for their use in various therapies.