CAS: 54143-57-6; Metoclopramide Hydrochloride

专利信息

专利号:US-5231198-A
优先权日:1992-07-06
标题:Asymmetric synthesis of hexahydrodibenzofurans by stereospecific inversion of ortho substituted 2-phenylcyclohexanols
发明人：POWERS MATTEW R; GOLEC FREDERICK A
权利人:RHONE POULENC RORER PHARMA
摘要:This invention relates to the stereospecific process for the preparation, separation and purification of hexahydrodibenzofurans which are used in the preparation of the 5HT 3 compounds. More specifically, the present invention relates to a process for the preparation of substantially optically pure cishexahydrodibenzofuran compounds including at least two chiral fused ring centers which comprises the acidic catalyzed stereospecific ring closure by the intra-molecular inversion of a gamma, i.e. 2', carbon atom of a 2-[(2'-leaving group)cycloalkyl]phenol.

专利号:US-5086179-A
优先权日:1988-04-27
标题 :Process for the preparation of optically pure amides
发明人：POWERS MATTHEW R; YOUSSEFYEH RAYMOND D; STUDT WILLIAM L; GOLEC FREDERICK A
权利人:RHONE POULENC RORER PHARMA
摘要:This invention is directed to certain dibenzofurancarboxamides and dibenzofurancarboxamide acids and their use as 5HT 3 antagonists having unique CNS, anti-emetic and gastric prokinetic activity void of any significant D 2 receptor binding properties. Further, this invention relates to a process for the synthesis of stereoisomeric compounds having such CNS, anti-emetic and gastric prokinetic activity.

专利号:US-2006205714-A1
优先权日:2004-04-01
标 题 :Method of synthesis and isolation of solid N-desmethylclozapine and crystalline forms thereof
发明人：TOLF BO-RAGNAR; THYGESEN MIKKEL B; BLATTER FRITZ; BERGHAUSEN JORG
权利人:TOLF BO-RAGNAR; THYGESEN MIKKEL B; BLATTER FRITZ; BERGHAUSEN JORG
摘要:Disclosed herein are crystalline Forms A, B, C, D, and E of N-desmethylclozapine, methods of preparing the same, pharmaceutical compositions comprising the same, and methods of therapeutic treatment involving N-desmethylclozapine polymorphic forms.

专利号:WO-9401428-A1
优先权日:1992-07-06
标 题 :Asymmetric synthesis of hexahydrodibenzofurans by stereospecific inversion of ortho substituted 2-phenylcyclohexanols

专利号:US-9751877-B2
优先权日:2012-09-21
标题 :Substituted pyrido[1,2-a]pyrazines for the treatment of neurodegenerative and neurological disorders
发明人：PETTERSSON MARTIN YOUNGJIN; JOHNSON DOUGLAS SCOTT; SUBRAMANYAM CHAKRAPANI; O'DONNELL CHRISTOPHER JOHN; AM ENDE CHRISTOPHER WILLIAM; GREEN MICHAEL ERIC; PATEL NANDINI CHATURBHAI; STIFF CORY MICHAEL; TRAN TUAN PHONG; KAUFFMAN GREGORY WAYNE; STEPAN ANTONIA FRIEDERIKE; VERHOEST PATRICK ROBERT
权利人:PFIZER
摘要:Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula I n nas defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.

专利号:CN-101535336-A
优先权日:2006-11-10
标题 :Synthesis of Phthalamide and Its Dimer