CAS: 593-39-5; (Z)-Octadec-6-Enoic Acid

该化合物是一种单饱和脂肪酸,主要见于某些植物的种子,特别是鹦鹉和椰菜中的种子,被归类为美洲六脂肪酸,其特点是18碳链和甲基端第六碳的双联.这一独特结构有助于其独特的物理和化学特性,包括与其他不饱和脂肪酸相比,一个相对较高的熔点.众所周知,石化盐酸具有潜在的健康效益,包括防炎和抗氧化特性,目前正在研究其在各种生物过程中的作用.在溶解性方面,它溶于有机溶剂中,但水溶性有限.酸可以用于各种用途,包括食品,化妆品和药品,因为其乳化和稳定特性.

结构式图片

欧盟法规

ECHA物质ECHA物质C&L通报REACH预注册

上下游产品

°Ctadec-6-ynoic acid erythro-6,7-Dihydroxy°Ctadecanoic acid ethanol 6,7-dibromo-°Ctadecanoic acidmethyl petroselinate cis-Petroselinsaeure-propylester ethyl petroselinate Petroselaidic acid

合成工艺路线路线简述

    1,10-Dichlor-Decin-5置于喹啉,盐酸,甲醇,氢氧化钾,Lindlar'S Catalyst,二丁醚,Sodium Methylate,乙酸乙酯,丙酮体系中,化学反应生成 十八碳6烯酸
    参考文献:Baker Et Al.,Journal Of The Chemical Society,1954,P. 1804,1807
    标题:Baker Et Al.,Journal Of The Chemical Society,1954,P. 1804,1807

    海关参考信息

    专利信息


    专利号:US-9943544-B2
    优先权日:2015-03-18
    标 题:Process for bio synthesis of nano arsenic trioxide and its use in treatment of diseases including cancer
    发明人:BENDALE YOGESH NARAYAN; BENDALE VINEETA YOGESH
    权利人:BENDALE YOGESH NARAYAN; BENDALE VINEETA YOGESH
    摘要:The present invention is a process for bio synthesis of nano arsenic trioxide defined by its low toxicity, higher bio availability and nano particle size with the aid of buttermilk, goat urine, dolichos biflorous and other plant materials such as ginger, momordica charantia and musa paradisiaca . The invention is carried out in different steps involving purification of crude form of arsenic trioxide by boiling it with buttermilk, goat urine and extract of dolichos biflorous in subsequent steps, followed by the trituration of the bio purified arsenic trioxide with extracts of ginger and momordica charantia in subsequent steps and heating of the dry product obtained after trituration with musa paradisiaca resulting in the production of novel nano arsenic trioxide. The product is effective in the treatment of various diseases including different types of cancer in animals and humans. The product obtained through the process is less toxic with higher bio availability.

    专利号:US-8642792-B2
    优先权日:2007-02-15
    标题 :Method for the synthesis of omega-amino-alkanoic acids
    发明人:DUBOIS JEAN-LUC
    权利人:DUBOIS JEAN-LUC; ARKEMA FRANCE
    摘要:The invention relates to a method for the synthesis of amino acids/esters of general formula NH 2 —(CH 2 ) n —COOR in which n is an integer between 5 and 14, and R is either H or an alkyl radical including from 1 to 4 carbon atoms, from natural long-chain mono-unsaturated fatty acids or esters including at least 10 adjacent carbon atoms per molecule, said method comprising: first converting, if necessary, said natural long-chain fatty acid or ester into a monounsaturated fatty acid/ester of general formula R 1 —(CH 2 ) m —CHâ•?CH—(CH 2 ) p —COOR in which R 1 is H, CH 3 or a COOR radical, m is an integer between 0 and 14 and p is an integer between 2 and 11, then submitting the latter to a crossed catalytic metathesis reaction with a compound of formula R 2 —CHâ•?CH—R 3 in which R 2 is either H or CN and R 3 is CN or CH 2 NH 2 , provided that if R 2 is CN, R 3 can be only CN, and finally converting the resulting product of the general formula R 3 —CHâ•?CH—(CH 2 ) p —COOR into an amino-acid, either by hydrogenation, or by hydrogenation of the trple terminal bond, or by amination of the double terminal bond.

    专利号:EP-2198036-B1
    优先权日:2007-09-20
    标 题:Method for the synthesis of omega-unsaturated fatty acids
    发明人:DUBOIS JEAN-LUC
    权利人:ARKEMA FRANCE
    摘要:The invention relates to a method for the synthesis of short-chain ω-unsaturated fatty acids of general formula CH2â•?CH—(CH2)n—COOR in which n is an integer between 2 and 11 and R is H or an alkyl radical containing from 1 to 4 carbon atoms, from long-chain monounsaturated fatty acids or esters of formula CH3—(CH2)m—CHâ•?CH—(CH2)p—COOR in which m and p are integers, either identical or different, between 2 and 11, such that the molecule contains at least 10 adjacent carbon atoms in the main chain, said method comprises the first step of submitting the long-chain monounsaturated fatty acid charge to an oxidation by fermentation using a microorganism containing enzymes of oxygenase type, thus leading to the formation of α,ω-diacids, and then a second step of subjecting the product from the first step to a catalytic metsthesis crossed with ethylene for forming two short-chain ω-unsaturated fatty acids having a main chain length relative to that of the starting unsaturated fatty acid or ester of beteen 0.2 and 0.8, and preferably 0.35 and 0.75.

    专利号:US-8647848-B2
    优先权日:2008-06-13
    标题:Enzymatic synthesis of sphingolipids
    发明人:HOLLMANN FRANK; THUM OLIVER; TOELLE CHRISTOPH; PROVINZANO ANGELO; KOREVAAR CORNELIS GERRIT NIJS
    权利人:HOLLMANN FRANK; THUM OLIVER; TOELLE CHRISTOPH; PROVINZANO ANGELO; KOREVAAR CORNELIS GERRIT NIJS; EVONIK GOLDSCHMIDT GMBH
    摘要:The invention relates to the enzymatic synthesis of sphingolipids and compositions that contain sphingolipids from lysosphingolipids and carbonic esters, and to cosmetic, dermatological or pharmaceutical formulations containing said sphingolipids or compositions.

    专利号:US-9023626-B2
    优先权日:2007-09-20
    标 题:Methods for the synthesis of fatty diacids by the metathesis of unsaturated diacids obtained by fermentation of natural fatty acids
    发明人:DUBOIS JEAN-LUC
    权利人:DUBOIS JEAN-LUC; ARKEMA FRANCE
    摘要:The invention relates to a method for the synthesis of diacids of general formula ROOC—(CH 2 ) n —(CHâ•?CH) a —(CH 2 ) m COOR 1 in which n and m are identical or different and each represent an integer such that their sum is between 6 and 15, a is an index of 0 or 1, and R and R 1 are H or an alkyl radical with 1 to 4 carbon atoms, from long-chain mono-unsaturated natural fatty acids or esters having at least 10 adjacent carbon atoms per molecule of the general formula CH 3 —(CH 2 ) p —CHâ•?CH—(CH 2 ) q —COOR, p and q, being identical or different and representing indices between 2 and 11, wherein said method comprises the first step of oxidizing by fermentation said natural fatty acid or ester, using a microorganism, such as a bacterium, a yeast, or a fungus, into at least one unsaturated dicarboxylic acid or dicarboxylate, the second step of submitting the product from the first step to a metathesis crossed with a compound of formula R 2 OOC—(CH 2 ) x —CHâ•?CH—R 3 , in which R 2 is H or an alkyl radical with 1 to 4 carbon atoms, x is 0 or 1 or 2, and R 3 is H, CH 3 or COOR 2 , in order to obtain the unsaturated compound of formula ROOC—(CH 2 ) q —CHâ•?CH—(CH 2 ) x —COOR 2 , and the third optional step of converting the usaturated compound into a saturated compound by hydrogenation of the double bond.

    专利号:US-9567293-B2
    优先权日:2013-02-08
    标题 :Combined synthesis of a nitrile-ester/acid and of a diester/diacid
    发明人:DUBOIS JEAN-LUC; COUTURIER JEAN-LUC; BRANDHORST MARKUS
    权利人:ARKEMA FRANCE
    摘要:A method for the combined synthesis of a mono-unsaturated nitrile-ester(acid) and of a bi-functional carbonyl compound, wherein it includes a step including the cross metathesis mc1 of an unsaturated fatty acid/ester compound with an unsaturated nitrile compound, in which mc1 is performed with partial conversion such as to obtain and recover, separately, at least the following products: a mono-unsaturated nitrile-ester/acid and a symmetrical compound, diester or diacid respectively including a double bond located in the middle of the molecular chain of compound, and subsequently a step including the oxidation cleavage cp2 of the double bond of compound, such as to form a single type of carbonyl compound having formula R2-(CH2)n-COR′, in which R′ is H or OH, depending on the operating conditions selected for the oxidation cleavage cp2. Also, the production of monomers for the polymer industry.
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    合成参考文献


    摘要:S109 | PARCEDC | List of 7074 potential endocrine disrupting compounds (EDCs) by PARC T4.2 | DOI:10.5281/zenodo.10944198
    参考文献:10.1007/bf02522974
    摘要:Kocsis MG, Weselake RJ. Phosphatidate phosphatases of mammals, yeast, and higher plants. Lipids. 1996 Aug;31(8):785–802. doi: 10.1007/bf02522974.
    参考文献:10.1007/bf02536477
    摘要:Pfeffer PE, Sonnet PE, Schwartz DP, Osman SF, Weisleder D. Effects ofbis homoallylic and homoallylic hydroxyl substitution on the olefinic13C resonance shifts in fatty acid methyl esters. Lipids. 1992 Apr;27(4):285–8. doi: 10.1007/bf02536477.
    参考文献:10.1007/bf00039536
    摘要:Sakamoto T, Los DA, Higashi S, Wada H, Nishida I, Ohmori M, Murata N. Cloning of omega 3 desaturase from cyanobacteria and its use in altering the degree of membrane-lipid unsaturation. Plant Mol Biol. 1994 Oct;26(1):249–63. doi: 10.1007/bf00039536.
    参考文献:10.1093/jn/129.12.2006
    摘要:Weber N, Schönwiese S, Klein E, Mukherjee KD. Adipose Tissue Triacylglycerols of Rats Are Modulated Differently by Dietary Isomeric Octadecenoic Acids from Coriander Oil and High Oleic Sunflower Oil. The Journal of Nutrition. 1999 Dec;129(12):2206–11. doi: 10.1093/jn/129.12.2006.
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