CAS: 614-75-5; 2-Hydroxyphenylacetic Acid

上下游产品

1-benzofurane 2-methoxyphenylacetic acid ethanol 2-chlorobenzo[b]furan methyl (2-hydroxyphenyl)acetate benzofuran-2(3H)-one (2-Carboxymethoxy-phenyl)-essigsaeure 2-methoxyphenylacetic acid

2-烯丙基酚置于4-二甲氨基吡啶,磷酸,双氧水,碳酸氢钠,臭氧体系中,用 甲醇,水 作为反应溶剂,化学反应 10.0H,反应生成 邻羟基苯乙酸
参考文献:一种邻羟基苯乙酸的合成方法
标题:一种邻羟基苯乙酸的合成方法
摘要:本发明属于医药中间体合成技术领域,具体涉及一种邻羟基苯乙酸的合成方法.包括以下步骤:(1)以邻烯丙基苯酚为原料,与乙酸酐反应获得邻烯丙基乙酸苯酯;(2)邻烯丙基乙酸苯酯经臭氧氧化,双氧水氧化两步反应获得邻乙酰氧基苯乙酸;(3)邻乙酰氧基苯乙酸水解获得邻羟基苯乙酸.本发明的合成方法条件温和,收率高,无环境污染,适合工业化生产.

专利信息

专利号:US-6469133-B2
优先权日:1999-12-13
标题 :Process for the preparation of polymers of dimeric cyclic esters
发明人：BAKER GREGORY L; SMITH III MILTON R
权利人:UNIV MICHIGAN STATE
摘要:The present invention provides a process for the direct synthesis of high melting polymers made from dimeric cyclic esters. In particular, the present invention provides a process for synthesis of polylactic acid (PLA) from racemic materials such as racemic lactide and polymandelide from mandelide. The process further provides racemic metal organic ligand catalysts such as racemic salbinap that catalyzes the polymerization of racemic dimeric cyclic ester monomers to a polylactide stereocomplex. Polymandelide and mixed dimeric cyclic esters are also prepared in the presence of low amounts of water.

专利号:WO-2020130862-A1
优先权日:2018-12-17
标题:Lyophilized fertilizer composition comprising iron siderophore chelates, lyophilized composition comprising siderophores, their processes of obtention and uses to treat plants
发明人：MONTEIRO SOARES HELENA MARIA VIEIRA; HENRIQUES FERREIRA CARLOS MIGUEL; VALENTE SOARES EDUARDO JORGE; LUCENA MAROTTA JUAN JOSÉ; LOPÉZ RAYO SANDRA
权利人:UNIV DO PORTO; INST SUPERIOR DE ENGENHARIA DO PORTO; UNIV MADRID AUTONOMA
摘要:Lyophilized fertilizer composition comprising iron siderophore chelates and a stabilizing agent and a lyophilized composition comprising siderophores and a stabilizing agent, wherein the stabilizing agent is starch. The invention further relates to processes of obtaining a lyophilized fertilizer composition and a lyophilized composition comprising a step of synthesis of at least one siderophore compound by means of biochemical transformation performed by at least one microorganism, and to the use of the compositions for treating cultivated plants, for example in conditions of low iron availability, wherein the compositions are capable of correcting chlorosis in plants and do not present environmental risks. The lyophilized fertilizer composition and the lyophilized composition have high storage stability.

专利号:WO-2011106929-A1
优先权日:2010-03-02
标题:Inhibitors of hepatitis c virus ns5b polymerase
发明人：MCCOMAS CASEY CAMERON; LIVERTON NIGEL J; HABERMANN JOERG; KOCH UWE; NARJES FRANK; LI PENG; PENG XUANJIA; SOLL RICHARD; WU HAO
权利人:MERCK SHARP & DOHME; ANGELETTI P IST RICHERCHE BIO; MCCOMAS CASEY CAMERON; LIVERTON NIGEL J; HABERMANN JOERG; KOCH UWE; NARJES FRANK; LI PENG; PENG XUANJIA; SOLL RICHARD; WU HAO
摘要:Compounds of formula I that are used as hepatitis C virus (HCV) NS5B polymerase inhibitors, the synthesis of such compounds, and the use of such compounds for inhibiting HCV NS5B polymerase activity, for treating or preventing HCV infection and for inhibiting HCV viral replication and /or viral production in a cell-based system.

专利号:US-2004110228-A1
优先权日:2002-04-01
标 题:Combinatorial organic synthesis of unique biologically active compounds
发明人：MCALPINE SHELLI R; TAYLOR RACHEL E; BOLLA MEGAN L; SEGALL ANCA M
摘要:The invention provides a method for making a combinatorial library of cyclic compounds, such as Holliday junction-trapping compounds, comprising the steps of (a) obtaining a plurality of trimers according to the generic structure X 1- X 2- X 3 , wherein X 1 , X 2 and X 3 can be independently any naturally or nonnaturally occurring amino acids or peptidomimetics thereof; (b) optionally coupling a spacer S to the trimer at either end; (c) cyclizing two trimers or trimer-spacer conjugates in a head-to-tail orientation; thereby obtaining a combinatorial library of compounds, wherein the library does not include an unmodifed or naturally occurring Holliday Junction-trapping compounds. The invention additionally provides methods macrocyclic compounds that are synergimycin derivatives.

专利号:WO-2011106986-A1
优先权日:2010-03-02
标题:Inhibitors of hepatitis c virus ns5b polymerase
发明人：MCCOMAS CASEY CAMERON; LIVERTON NIGEL J; SOLL RICHARD; LI PENG; PENG XUANJIA; WU HAO
权利人:MERCK SHARP & DOHME; MCCOMAS CASEY CAMERON; LIVERTON NIGEL J; SOLL RICHARD; LI PENG; PENG XUANJIA; WU HAO
摘要:Compounds of formula (I) that are used as hepatitis C virus (HCV) NS5B polymerase inhibitors, the synthesis of such compounds, and the use of such compounds for inhibiting HCV NS5B polymerase activity, for treating or preventing HCV infections and for inhibiting HCV viral replication and /or viral production in a cell-based system. Wherein Z, R 30 , R 40 , R 50 and R 60 of compounds of formula (I) are herein defined as in the description.

专利号:US-9453037-B2
优先权日:2011-07-28
标 题 :Methylphenidate-prodrugs, processes of making and using the same
发明人：GUENTHER SVEN; CHI GUOCHEN; BERA BINDU; MICKLE TRAVIS; BERA SANJIB
权利人:KEMPHARM INC; KEMPHARM INC
摘要:The present technology is directed to prodrugs and compositions for the treatment of various diseases and/or disorders comprising methylphenidate, or methylphenidate derivatives, conjugated to at least one alcohol, amine, oxoacid, thiol, or derivatives thereof. In some embodiments, the conjugates further include at least one linker. The present technology also relates to the synthesis of methylphenidate, or methylphenidate derivatives, conjugated to at least one alcohol, amine, oxoacid, thiol, or derivatives thereof or combinations thereof.