CAS: 632-46-2; 2,6-Dimethylbenzoic Acid

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CAS号118-90-1 邻甲基苯甲酸 | CAS号13061-96-6 甲基硼酸 | CAS号17264-71-0 sodium,2-methyl... | CAS号526-73-8 1,2,3-三甲苯 | CAS号124-38-9 二氧化碳 | CAS号576-22-7 2-溴间二甲苯 | CAS号201230-82-2 carbon monoxide | CAS号2192-33-8 2,6-dimethylben... | CAS号64-18-6 甲酸 | CAS号54708-14-4 2,6-二甲基苯乙腈 | CAS号22004-65-5 α-(2,6-二甲基苯基)-2... | CAS号179554-33-7 3-(Chloromethyl... | CAS号36596-67-5 2,6-二甲基苯甲酸乙酯 | CAS号576-26-1 2,6-二甲基苯酚 | CAS号83902-02-7 2-(溴甲基)-1,3-二甲基苯 | CAS号2211-84-9 7-甲基苯酞 | CAS号587-03-1 3-甲基苄醇 | CAS号620-23-5 间甲基苯甲醛 | CAS号74788-82-2 2,6-二甲基苄胺

3-甲基-2-溴苄溴置于bis(1,5-Cyclooctadiene)Nickel (0),Magnesium,1,3-双(2,6-二异丙基苯基)咪唑-2-烯体系中,用 乙醚,均三甲苯 作为反应溶剂,20.0~160.0 °C,101.33 Kpa 条件下,反应 31.17H,反应生成 2,6-二甲基苯甲酸
参考文献:位点和区域选择性地将二氧化碳掺入苯并硅杂环丁烯的 C(Sp2)-Si 键中
标题:位点和区域选择性地将二氧化碳掺入苯并硅杂环丁烯的 C(Sp2)-Si 键中
摘要:苯并硅杂环丁烯与二氧化碳的反应由具有 N-杂环卡宾配体的镍配合物催化.二氧化碳以位点和区域选择性的方式插入 C(Sp2)-Si 键,形成碳-碳键,提供苯甲酸衍生物.
DOI:10.1246/cl.171211

专利信息

专利号:US-11912647-B2
优先权日:2020-05-22
标 题:Diversity-oriented synthesis of N,N,O-trisubstituted hydroxylamines from alcohols and amines by N—O bond formation
发明人：CRICH DAVID; HETTIKANKANAMALAGE ASIRI; HILL JARVIS
权利人:UNIV GEORGIA
摘要:In one aspect, the disclosure relates to a method for the direct synthesis of complex N,N,O-trisubstituted hydroxylamines by N—O bond formation. In another aspect, the method can successfully be employed using a wide variety of commercially available alcohols and secondary amines and enables the construction of large fragment-based libraries of trisubstituted hydroxylamines for drug discovery purposes. Also disclosed are N,N,O-trisubstituted hydroxylamines having low basicity, high stability at ambient temperatures, and an inherent lack of reactivity towards acetylating and sulfonylating enzymes that confer mutagenicity on less-substituted hydroxylamines.

专利号:EP-1611083-B1
优先权日:2003-03-25
标 题:Synthesis of 2-chloromethyl-6-methylbenzoic acid esters
发明人：MAIER CLAUS-JUERGEN; METZENTHIN TOBIAS; GRAESER JOACHIM; BICKER RICHARD; MANERO JAVIER
权利人:SANOFI AVENTIS DEUTSCHLAND
摘要:The invention relates to a method for producing compounds of formula (I) wherein R represents H, optionally halogen-substituted alkyl, cycloalkyl or aryl, alkyl-aryl or heteroaryl, and at least one CH2 group can be replaced by O in alkyl and cycloalkyl. Said compounds of formula (I) are valuable intermediates in the synthesis of PPAR agonists.

专利号:US-6989462-B2
优先权日:2003-03-25
标题:Synthesis of 2-chloromethyl-6-methylbenzoic ester
发明人：MAIER CLAUS-JUERGEN; METZENTHIN TOBIAS; GRAESER JOACHIM; BICKER RICHARD; MANERO JAVIER
权利人:SANOFI AVENTIS DEUTSCHLAND
摘要:A process is described for preparing compounds of formula (I) n nwhere R is H, optionally halogen-substituted alkyl, cycloalkyl, aryl, alkyl-aryl or heteroaryl, and, in alkyl and cycloalkyl, one or more CH 2 groups may be replaced by —O—. The compounds of the formula (I) are valuable intermediates in the synthesis of PPAR agonists.

专利号:US-6528275-B1
优先权日:1996-04-24
标题:Substrates and inhibitors of proteolytic enzymes
发明人：QUIBELL MARTIN; JOHNSON TONY; HART TERANCE
权利人:MEDIVIR UK LTD
摘要:The present invention relates to the field of compounds which are substrates or inhibitors of proteolytic enzymes and to apparatus and methods for identifying substrates or inhibitors for proteolytic enzymes. We have devised a combinatorial method for the rapid indentification of binding motifs which will greatly expedite the synthesis of inhibitors of a variety of proteolytic enzymes such as aspartyl proteases, serine proteases, metallo proteases and cysteinyl proteases.

专利号:WO-2024146948-A1
优先权日:2023-01-05
标题:Peptide synthesis method involving sterically hindered tri-tert-butyl-tryptophan (tbt) residue
发明人：EKSTEEN JACOBUS JOHANNES; SVENDSEN JOHN SIGURD; MALMEDY FLORENCE; GUEVARA JONATHAN
权利人:AMICOAT AS
摘要:The invention is directed to a method of peptide synthesis comprising reacting a compound of Formula (I) or a salt thereof with a carbodiimide reagent to form an O-acylisourea intermediate; reacting the O-acylisourea intermediate with an additive to form an activated ester; and reacting the activated ester with an amino-containing moiety which is an amino acid, a peptide or a salt thereof comprising an amino group, wherein the amino group forms an amide bond with the carbonyl marked * in Formula (I); wherein the compound of Formula (I) has the structure: and wherein R1 and R2 are as defined in the disclosure. The invention is also directed to a compound of Formula (III) as defined in the disclosure or a salt thereof.

专利号:US-2005124683-A1
优先权日:2003-09-17
标 题:HIV protease inhibitors, compositions containing the same, their pharmaceutical uses and materials for their synthesis
发明人：ALEGRIA LARRY A; CANAN-KOCH STACIE S; DRESS KLAUS R; HUANG BUWEN; KUMPF ROBERT A; LEWIS KATHLEEN K; MATTHEWS JEAN J; SAKATA SYLVIE K; VIRGIL SCOTT C
权利人:AGOURON PHARMA
摘要:The present invention relates to a series of chemical compounds useful as Human Immunodeficiency Virus (HIV) protease inhibitors and to the use of such compounds as antiviral agents. The invention further relates to pharmaceutical compositions containing such antiviral agents, and their uses and materials for their synthesis