CAS: 698-90-8; 1-Cyclohexylurea

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环己胺置于甲醇体系中,用 Neat (No Solvent) 作为反应溶剂,化学反应 2.0H,反应生成 N-环己基脲
参考文献:通过使用分子氢的钯催化还原烷基化,一锅,无溶剂获得不对称尿素
标题:通过使用分子氢的钯催化还原烷基化,一锅,无溶剂获得不对称尿素
摘要:在醛的存在下并使用分子氢作为清洁还原剂,研究了钯催化的单取代脲的还原烷基化.不对称的 N,N'-二取代脲以非常好至极好的分离产率 (60-93%) 形成,而不会产生盐废物.该反应被纳入一锅,无溶剂的序列中,包括从相应的胺原位反应生成的单取代脲的烷基化.
DOI:10.1002/ejoc.201300642

专利信息

专利号:US-4287123-A
优先权日:1980-01-14
标题 :Synthesis of thienamycin via (3SR, 4RS)-3-((RS)-1-acyloxyethyl)-2-oxo-4-azetidineacetate
发明人：LIU THOMAS M H; MELILLO DAVID G; RYAN KENNETH M; SHINKAI ICHIRO; SLETZINGER MEYER
权利人:MERCK & CO INC
摘要:Disclosed is a process for the stereocontrolled total synthesis of thienamycin, which synthesis proceeds via intermediate II: II wherein R is a readily removable carboxyl protecting group; and is a readily removable acyl group.

专利号:US-9862745-B2
优先权日:2004-03-30
标题 :Synthesis of boronic ester and acid compounds
发明人：AMMOSCATO VINCE; BISHOP JOHN E; CHIU FANG-TING; GEISER ACHIM; GOMEZ JEAN-MARC; HETT ROBERT; KOELLNER CHRISTOPH; KULKARNI VITHALANAND R; LO YOUNG; MUNK STEPHEN; PICKERSGILL I FRASER
权利人:MILLENNIUM PHARM INC; MILLENNIUM PHARM INC
摘要:The invention relates to the synthesis of boronic ester and acid compounds. More particularly, the invention provides improved synthetic processes for the large-scale production of boronic ester and acid compounds, including the peptide boronic acid proteasome inhibitor bortezomib.

专利号:US-4349687-A
优先权日:1980-01-14
标 题:Intermediate for synthesis of thienamycin via (3SR, 4RS)-3-[1 (SR)-hydroxyethyl]-2-oxo-4-azetidineacetic acid
发明人：LIU THOMAS M H; MELILLO DAVID G; RYAN KENNETH M; SHINKAI ICHIRO; SLETZINGER MEYER
权利人:MERCK & CO INC
摘要:Disclosed is a process for the stereocontrolled total synthesis of thienamycin via intermediates II and IIa: II IIa wherein R is a readily removable carboxyl protecting group.

专利号:US-4473502-A
优先权日:1981-04-08
标题 :Synthesis of thienamycin via (3SR, 4RS)-3-[1 (SR)-hydroxyethyl]-2-oxo-4-azetidineacetic acid
发明人：LIU THOMAS M H; MELILLO DAVID G; RYAN KENNETH M; SHINKAI ICHIRO; SLETZINGER MEYER
权利人:MERCK & CO INC
摘要:Disclosed is a process for the stereocontrolled total synthesis of thienamycin via intermediates II and IIa: wherein R is a readily removable carboxyl protecting group.

专利号:US-5712269-A
优先权日:1993-04-05
标题 :M2 receptor ligand for the treatment of neurological disorders
发明人：MCCABE R TYLER; WILSON BRYAN R; RHODES CHRISTOPHER A
权利人:PHARMACEUTICAL DISCOVERY CORP
摘要:Muscarinic M2 receptor ligands are described which are suitable for the treatment of neurological disorders, and which may be administered with minimal side-effects. A method of synthesis of these compounds is also described.

专利号:US-6677120-B2
优先权日:2001-03-30
标 题 :Building blocks for the solution phase synthesis of oligonucleotides
发明人：SANGHVI YOGESH S; GOTOR VICENTE; FERRERO MIGUEL; FERNANDEZ SUSANA; GARCIA JAVIER
权利人:ISIS PHARMACEUTICALS INC
摘要:The present invention is directed to methods for the preparation of 3′-O and 5′-O-levulinyl nucleosides from common precursors using an enzymatic approach.