CAS: 7003-32-9; 2-Methylcyclohexylamine

相似化合物

39558-31-1 79389-39-2 79389-41-6

上下游产品

CAS号1122-26-5 (1Z)-2-甲基环己酮肟 | CAS号583-60-8 2-甲基环己酮 | CAS号103890-73-9 cis- and trans-... | CAS号95-53-4 邻甲苯胺 | CAS号32179-88-7 (2-methyl-cyclo... | CAS号583-59-5 2-甲基环己醇 | CAS号7664-41-7 氨 | CAS号1122-26-5 (1Z)-2-甲基环己酮肟 | CAS号591-49-1 1-甲基-1-环己烯 | CAS号82166-21-0 2-methyl cyclohexane | CAS号96-37-7 甲基环戊烷 | CAS号1982-49-6 环草隆 | CAS号1640-89-7 乙基环戊烷 | CAS号850566-18-6 2,4-ditert-buty... | CAS号583-60-8 2-甲基环己酮

2-甲基环己酮置于盐酸,9-Borabicyclo[3.3.1]Nonane Dimer,Ammonium Acetate体系中,用 甲醇 作为反应溶剂,化学反应 42.0H,以31%的收率获得产物2-甲基环己胺
参考文献:一般的,高度立体选择性的胺合成
标题:一般的,高度立体选择性的胺合成
摘要:描述了通过各种氢化硼试剂还原环烷酮亚胺的立体化学过程.据报道,用取代的碱金属硼氢化物具有很高的立体选择性.
DOI:10.1016/s0040-4039(01)81928-6

专利信息

专利号:US-6133018-A
优先权日:1997-06-02
标 题 :Enzymatic synthesis of chiral amines using -2-amino propane as amine donor
发明人：WU WEI; BHATIA MOHIT B; LEWIS CRAIG M; LANG WEI; WANG ALICE L; MATCHAM GEORGE W
权利人:CELGRO
摘要:2-Aminopropane is used as the amine donor in the stereoselective synthesis of a chiral amine from a ketone with a transaminase. In a typical embodiment, (S)-1-methoxy-2-aminopropane is prepared by bringing methoxyacetone into contact with a transaminase in the presence of 2-aminopropane as an amine donor until a substantial amount of methoxyacetone is converted to (S)-1-methoxy-2-aminopropane and 2-aminopropane is converted to acetone. In a second embodiment, L-alanine is prepared by bringing pyruvic acid into contact with a transaminase in the presence of 2-aminopropane as an amine donor.

专利号:EP-1075534-B8
优先权日:1998-03-11
标 题 :Improvements in the enzymatic synthesis of chiral amines
发明人：WU WEI; BHATIA MOHIT B; LEWIS CRAIG M; LANG WEI; WANG ALICE; MATCHAM GEORGE W
权利人:CELGRO
摘要:2-Aminopropane is used as the amine donor in the stereoselective synthesis of a chiral amine from a ketone with a transaminase. In a typical embodiment, (S)-1-methoxy-2-aminopropane is prepared by bringing methoxyacetone into contact with a transaminase in the presence of 2-aminopropane as an amine donor until a substantial amount of methoxyacetone is converted to (S)-1-methoxy-2-aminopropane and 2-aminopropane is converted to acetone. In a second embodiment, L-alanine is prepared by bringing pyruvic acid into contact with a transaminase in the presence of 2-aminopropane as an amine donor.

专利号:US-5300437-A
优先权日:1989-06-22
标 题 :Enantiomeric enrichment and stereoselective synthesis of chiral amines
发明人：STIRLING DAVID I; MATCHAM GEORGE W; ZEITLIN ANDREW L
权利人:CELGENE CORP
摘要:Amines in which the amino group is on a secondary carbon atom which is chirally substituted can be enantiomerically enriched by the action of an omega-amino acid transaminase which has the property of preferentially converting one of the two chiral forms to a ketone. The process also can be used to stereoselectively synthesize one chiral form from ketones substantially to the exclusion of the other.

专利号:US-5169780-A
优先权日:1989-06-22
标题:Enantiomeric enrichment and stereoselective synthesis of chiral amines
发明人：STIRLING DAVID I; ZEITLIN ANDREW L; MATCHAM GEORGE W; ROZZELL JR JAMES D
权利人:CELGENE CORP
摘要:Amines in which the amino group is on a secondary carbon atom which is chirally substituted can be enantiomerically enriched by the action of an omega-amino acid transaminase which has the property of preferentially converting one of the two chiral forms to a ketone. The process can be used to stereoselectively sythesize one chiral form from ketones substantially to the exclusion of the other. An aqueous solution of chiral amines after being brought into contact with an omega-amino acid transaminase and an amino acceptor is treated with a water-immiscible organic solvent, the aqueous and organic phases are separated, and the aqueous phase can be recirculated for further contact with the transaminase.

专利号:US-8471023-B2
优先权日:2009-06-11
标 题:Reductive amination of 6-keto normorphinans by catalytic hydrogen transfer
发明人：GROTE CHRISTOPHER W; CANTRELL GARY L; MCCLURG JOSEPH P; THOMASSON CATHERINE E; MOSER FRANK W
权利人:GROTE CHRISTOPHER W; CANTRELL GARY L; MCCLURG JOSEPH P; THOMASSON CATHERINE E; MOSER FRANK W; MALLINCKRODT LLC
摘要:The present invention provides processes for the stereoselective synthesis of 6-alpha-amino morphinans. In particular, the invention provides processes for the reductive amination of 6-keto normorphinans by catalytic transfer hydrogenation.

专利号:US-4950606-A
优先权日:1989-06-22
标题 :Enantiomeric enrichment and stereoselective synthesis of chiral amines
发明人：STIRLING DAVID I; ZEITLIN ANDREW L; MATCHAM GEORGE W
权利人:CELGENE CORP
摘要:Amines in which the amino group is on a secondary carbon atom which is chirally substituted can be enantiomerically enriched by the action of an omega-amino acid transaminase which has the property of preferentially converting one of the two chiral forms to a ketone. The process also can be used to stereoselectively synthesize one chiral form from ketones substantially to the exclusion of the other.