CAS: 101-41-7; Methyl 2-Phenylacetate

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60-12-8 23786-13-2 53088-69-0

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CAS号67-56-1 甲醇 | CAS号201230-82-2 carbon monoxide | CAS号100-39-0 溴化苄 | CAS号60-12-8 苯乙醇 | CAS号108-88-3 甲苯 | CAS号103-82-2 苯乙酸 | CAS号616-38-6 碳酸二甲酯 | CAS号108-86-1 溴苯 | CAS号38330-80-2 丙二酸单甲酯钾盐 | CAS号1087-36-1 Benzeneacetic a... | CAS号104484-87-9 methyl N-[(2-ph... | CAS号1578-63-8 α-氟苯基乙酸 | CAS号56071-96-6 methyl 2,2-difl... | CAS号360-03-2 2,3-二氟苯乙酸 | CAS号17841-30-4 2-氟-2-苯基乙酸甲酯 | CAS号3469-00-9 二苯基乙酸甲酯 | CAS号3558-60-9 甲基苯乙基醚 | CAS号60-12-8 苯乙醇 | CAS号4606-15-9 苯乙酸丙酯

2-苄基磺酰基-1,3-苯并噻唑置于samarium Diiodide,Lithium Hexamethyldisilazane体系中,用 四氢呋喃,甲醇 用作溶剂,化学反应 0.75H,反应生成苯乙酸甲酯
参考文献:使用β-羰基bt砜作为常见中间体,将伯醇和仲醇的一碳和二碳同构成相应的羧酸酯
标题:使用β-羰基bt砜作为常见中间体,将伯醇和仲醇的一碳和二碳同构成相应的羧酸酯
摘要:本文中,我们报告了使用β-羰基苯并噻唑(bt)砜中间体通过mitsunobu反应将1°和2°醇有效地一碳和二碳同系化为它们相应的同系酯.一碳同系物方法使用标准的mitsunobu C-s键形成,氧化和随后的烷基化,而二碳同系物使用较少见的cc碳键形成mitsunobu反应.在后一种情况下,使用含β-Bt砜的酯会降低p K A足以将底物用作基于碳的亲核试剂并传递同源的β-Bt砜酯,然后可以裂解该多余的砜基.在本文中,我们描述了几种有效进行bt砜脱磺酰化的方法,并开发了用于一锅烷基化脱磺酰化序列的方法.因此,总的来说,可以通过两锅法(四步法)实现一碳同源序列,而通过两锅法(三步法)(三锅;在c-包括酸合成).该方法学已被应用于多种功能(酯,甲硅烷基醚,苄基,杂芳基,酮,烯烃和炔烃),并且均能很好地耐受,从而提供了很好的总收率.
Doi:10.1021/acs.Joc.8B00112

专利信息

专利号:US-6423877-B1
优先权日:1999-11-15
标题:Synthesis of pseudopterosin compounds
发明人：COREY ELIAS J
权利人:HARVARD COLLEGE
摘要:The present invention is directed to a new synthetic route to pseudopterosin aglycone (3): n a key intermediate for the synthesis of a group of antiinflammatory natural products including pseudopterosin A (1) and E (2). The pathway of synthesis starts with the abundant and inexpensive (S)-(−)-limonene and its long-known cyclic hydroboration product (4) and leads to the chiral hydroxy ketone (6). Conversion of (6) to (10) followed by a novel aromatic annulation produced (15) which underwent highly diastereoselective cyclization to afford the protected pseudopterosin aglycone (16). The naturally occurring pseudopterosins such as (1) and (2) are readily available from this key intermediate.

专利号:US-11999757-B2
优先权日:2017-11-01
标 题:Synthesis of boronate ester derivatives and uses thereof
发明人：BOYER SERGE HENRI; HECKER SCOTT J; VERZIJL GERARDUS K M; HERMSEN PETRUS J
权利人:MELINTA SUBSIDIARY CORP
摘要:Disclosed herein are methods for the preparation of boronate derivatives in the synthesis of antimicrobial compounds and uses thereof. Disclosed herein includes method of making a compound of Formula (B) by reducing the ketone group of the keto-ester compound of Formula (A), and the reduction can be performed using a Ruthenium based catalyst system or using an alcohol dehydrogenase bioreduction system.

专利号:US-10669292-B2
优先权日:2014-05-05
标 题 :Synthesis of boronate salts and uses thereof
发明人：HECKER SCOTT; BOYER SERGE
权利人:REMPEX PHARMACEUTICALS INC
摘要:Disclosed herein are boronate intermediates in the synthesis of antimicrobial compounds and the use and preparation thereof. Some embodiments relate to crystalline boronate salt derivatives and their use in the synthesis of therapeutic compounds.

专利号:US-6384228-B2
优先权日:1998-05-26
标题 :Method for synthesis of halopyridyl-azacyclopentane derivative and intermediate thereof
发明人：NODE MANABU; NAKAMURA DAISAKU; FUJIWARA TOSHIO; ICHIHASHI SHOGO
权利人:NIHON MEDIPHYSICS CO LTD
摘要:The present invention relates to a method for synthesis of an optically active halopyridyl-azacyclo-pentane derivative and the intermediate thereof which comprises preparing an optically active allene-1,3-dicarboxylic acid ester derivative from an optically active acetonedicarboxylic acid ester derivative and then proceeding through a 7-azabicyclo[2.2.1]heptane derivative to obtain the objective product.

专利号:US-9315483-B2
优先权日:2007-09-13
标题 :Synthesis of deuterated catechols and benzo[D][1,3]dioxoles and derivatives thereof
发明人：JONES ANDREW D; ZELLE ROBERT E; SILVERMAN I ROBERT
权利人:CONCERT PHARMACEUTICALS INC
摘要:The present invention provides a convenient and efficient process for the synthesis of d 2 -benzo[d][1,3]dioxoles.

专利号:US-2005014954-A1
优先权日:2001-11-22
标 题:Pyrrole synthesis
发明人：OHRLEIN REINHOLD; BAISCH GABRIELE
摘要:The invention relates to a novel process for the preparation of N-substituted pyrroles, especially of formula (V), wherein the radicals are as defined in the description, by intermolecular aza-Wittig reaction starting from organic azides and 1,4-dioxo compounds. The invention relates also to novel iminophosphorane intermediates for this synthesis. The resulting pyrroles are useful, for example, in the organic synthesis of pharmaceuticals or other active substances and chemicals.