CAS: 108605-62-5; 2-Cyano-3-Hydroxy-N-(4-(Trifluoromethyl)Phenyl)But-2-Enamide

上下游产品

Leflunomide sodium cyanide 2-bromo-3-oxo-N-[4-(trifluoromethyl)phenyl]butanamide 5-methyl-1,2-oxazole-4-carboxylic acid

专利信息

专利号:WO-2024256322-A1
优先权日:2023-06-13
标题 :Synthesis of non-ionic radiographic contrast agents by means of reactive extrusion
发明人：LATTUADA LUCIANO; SEBASTIANO ROBERTO; LEONARDI GABRIELLA; CRAVOTTO GIANCARLO; BARGE ALESSANDRO; BUCCIOL FABIO
权利人:BRACCO IMAGING SPA; MILANO POLITECNICO
摘要:The present invention relates to the industrial preparation of non-ionic X-ray contrast agents. In particular, it relates to a process for the synthesis of lopamidol using a reactive extrusion process in continuous which enable an efficient conversion of the relevant key intermediates, preferably in the absence of any solvent. The invention further relates to the preparation of radiographic X-rays contrast agents or key intermediates thereof by exploiting the technology of reactive extrusion.

专利号:WO-2022226312-A1
优先权日:2021-04-22
标 题:Combination nucleotide pool depletion for treatment of viral infections and cancers
发明人：KUMAR VIKRAM; HESSON DAVID; DEMAREST JAMES
权利人:CLEAR CREEK BIO INC
摘要:The invention provides methods of treating cancers and viral infections by providing a combination of agents that inhibit both nucleotide synthesis and nucleotide salvage in the cells of a subject to prevent cancer proliferation and viral replication. The invention provides methods of depleting nucleotide pools by using both inhibitors of dihydroorotate dehydrogenase (DHODH), such as brequinar, which block synthesis of pyrimidine-based nucleotides, in combination of one or more nucleotide salvage inhibitors, for example deoxycytidine kinase (dCK) inhibitors, Equilibrative nucleoside transporter (ENT) inhibitors, and Uridine-cytidine kinase (UCK) inhibitors, which inhibit salvage of purine and/or pyrimidine-based nucleotides or nucleosides

专利号:US-2005255071-A1
优先权日:1998-12-10
标 题 :Preparation having improved therapeutic breadth comprising nucleotide synthesis inhibitors
发明人：LINDNER JURGEN; HAASE BURKHARD
权利人:AVENTIS PHARMA GMBH
摘要:A preparation comprising a compound which essentially prevents the enterohepatic circulation of nucleotide synthesis inhibitors or antagonizes the action of the nucleotide synthesis inhibitors with a displacement in time, and a nucleotide synthesis inhibitor such as brequinar, mycophenolatemofetil (2-morpholinoethyl (E)-6-(1,3-dihydro-4-hydroxy-6-methoxy-7-methyl-3-oxoisobenzofuran-5-yl)-4-methyl-4-hexenoate), methotrexate, mizoribine and compounds of formulae (I) and (II) n nis suitable for the treatment of immunological disorders, cancer, or in transplantations.

专利号:US-6716411-B2
优先权日:1999-12-15
标 题:Method for finding nucleotide synthesis inhibitors having fewer side effects
发明人：LINDNER JUERGEN; HAASE BURKHARD
权利人:AVENTIS PHARMA GMBH
摘要:The invention relates to a method for finding nucleotide synthesis inhibitors which have a better therapeutic window. An efficacious dose of a nucleotide synthesis inhibitor is administered to a mammal. The concentration of the nucleotide synthesis inhibitor in the blood of the mammal is observed and it is determined whether the nucleotide synthesis inhibitor has a half-life which is shorter than that of N-(4-trifluoromethylphenyl)-2-cyano-3-hydroxycrotonamide. The invention also relates to a method of using nucleotide synthesis inhibitors in the treatment of immunological diseases.

专利号:US-11801232-B2
优先权日:2019-11-27
标 题 :Targeting of ARID1A-deficient cancers by inhibiting de novo pyrimidine synthesis pathway
发明人：HUANG GLORIA
权利人:UNIV YALE
摘要:This application relates to methods and kits for treating ARID1A-mutant tumors, cancers, or aberrantly proliferating cells and subjects harboring the tumors, cancers, or aberrantly proliferating cells. In particular, the methods provided include administering to the subject or cell an effective amount of a pyrimidine synthesis inhibitor and administering to the subject or cell an effective amount of a DNA repair inhibitor. The kits include a) a composition comprising a pyrimidine synthesis inhibitor and b) a composition comprising a DNA repair inhibitor.

专利号:US-12012383-B2
优先权日:2018-03-26
标题 :Compositions and methods for inhibiting dihydroorotate dehydrogenase
发明人：KUMAR VIKRAM S; HESSON DAVID P; HUANG PING; JIA MO; YOU XIANJUN
权利人:CLEAR CREEK BIO INC
摘要:The invention provides therapeutic compositions that contain an inhibitor of dihydroorotate dehydrogenase (DHODH) and promote sustained elevation of dihydroorotate (DHO) levels in a patient. The compositions are useful for treating disorders associated with unregulated DHODH activity, such as acute myeloid leukemia. The invention also provides methods of determining therapeutically effective doses of compositions that contain a DHODH inhibitor. The invention further provides methods of synthesis of 2-(2′-halo-1-1′-biphenyl-4-yl)-quinoline carboxylic acids, which are useful as DHODH inhibitors.