CAS: 1611493-60-7; (2R,5S,13Ar)-8-Hydroxy-7,9-Dioxo-N-(2,4,6-Trifluorobenzyl)-2,3,4,5,7,9,13,13A-Octahydro-2,5-Methanopyrido[1',2':4,5]Pyrazino[2,1-B][1,3]Oxazepine-10-Carboxamide

上下游产品

(2R,5S,13aR)-8-methoxy-7,9-dioxo-2,3,4,5,7,9,13,13a-°Ctahydro-2,5-methanopyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazepine-10-carboxylic acid (2R,5S,13aR)-8-methoxy-7,9-dioxo-N-[(2,4,6-trifluorophenyl)methyl]-2,3,4,5,7,9,13,13a-°Ctahydro-2,5-methanopyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazepine-10-carboxamide 1-(2,2-dihydroxyethyl)-5-methoxy-6-(methoxycarbonyl)-4-oxo-1,4-dihydropyridine-3-carboxylic acid 1-[2,2-bis(methyloxy)ethyl]-5-(methyloxy)-6-[(methyloxy)carbonyl]-4-oxo-1,4-dihydro-3-pyridinecarboxylic acid

Lithium (2R,5S,13Ar)-7,9-Dioxo-10-((2,4,6-Trifluorobenzyl)Carbamoyl)-2,3,4,5,7,9,13,13A-octahydro-2,5-Methanopyrido[1',2':4,5]Pyrazino[2,1-B][1,3]Oxazepin-8-Olate置于盐酸体系中,用 甲醇,水 用作溶剂,化学反应 1.0H,以78%的收率获得比卡格韦
参考文献: Process For The Preparation Of Sodium (2R,5S,13Ar)-7,9-Dioxo-10-((2,4,6-Trifluorobenzyl)Carbamoyl)-2,3,4,5,7,9,13,13A-octahydro-2,5-Methanopyrido[1',2':4,5]Pyrazino[2,1-B] [1,3] Oxazepin-8-Olate And Its Polymorphic Form[fr] Procédé De Préparation De (2R,5S,13Ar)-7,9-Dioxo-10-((2,4,6-Trifluorobenzyl)Carbamoyl)-2,3,4,5,7,9,13,13 A-octahydro-2,5-Méthanopyrido[1',2': 4,5]Pyrazino[2,1-B][1,3]Oxazépin-8-Olate Et Sa Forme Polymorphe
标题: Process For The Preparation Of Sodium (2R,5S,13Ar)-7,9-Dioxo-10-((2,4,6-Trifluorobenzyl)Carbamoyl)-2,3,4,5,7,9,13,13A-octahydro-2,5-Methanopyrido[1',2':4,5]Pyrazino[2,1-B] [1,3] Oxazepin-8-Olate And Its Polymorphic Form[fr] Procédé De Préparation De (2R,5S,13Ar)-7,9-Dioxo-10-((2,4,6-Trifluorobenzyl)Carbamoyl)-2,3,4,5,7,9,13,13 A-octahydro-2,5-Méthanopyrido[1',2': 4,5]Pyrazino[2,1-B][1,3]Oxazépin-8-Olate Et Sa Forme Polymorphe
摘要:本发明涉及一种制备化合物i的工艺,化合物i为钠(2R,5S,13Ar)-7,9-二氧基-10-((2,4,6-三氟苯甲基)氨基甲酰)-2,3,4,5,7,9,13,13A-八氢-2,5-甲基吡啶[1',2':4,5]吡嗪[2,1-B][1,3]噁唑-8-酸盐及其多晶形式.

专利信息

专利号:US-2024067621-A1
优先权日:2021-02-23
标 题:Polyfluorinated cannabinoid and cannabinoid-like compounds and methods of synthesis and use thereof
发明人：WEAVER JIMMIE D; DAY JON; GROTJAHN SASCHA; SENAWEERA SAMEERA; KOENIG BURKHARD
权利人:WEAVER JIMMIE D; DAY JON; GROTJAHN SASCHA; SENAWEERA SAMEERA; KOENIG BURKHARD; THE BOARD OF REGENTS FOR THE OKLAHOMA AGRICULTURAL AND MECH COLLEGES
摘要:Polyfluorinated compounds are disclosed, including polyfluorinated cannabinoid and cannabinoid-like compounds. Also disclosed are methods of producing the polyfluorinated compounds.

专利号:WO-2018229798-A1
优先权日:2017-06-13
标题 :Process for the preparation of bictegravir and intermediate thereof
发明人：PHULL MANJINDER SINGH; RAO DHARMARAJ RAMACHANDRA; BIRARI DILIP RAMDAS
权利人:CIPLA LTD
摘要:The present invention provides processes and intermediates for the synthesis of bictegravir and its pharmaceutical salt.

专利号:US-11248005-B2
优先权日:2019-07-08
标 题 :Process for preparation of intermediates used for the synthesis of HIV integrase inhibitor
发明人：JADHAV HARISHCHANDRA SAMBHAJI; SHRIVASTAVA DHANANJAI; AHER UMESH PARASHARAM; DEOKAR SHARAD CHANDRABHAN; NALE DEEPAK BABASAHEB; HONRAO SURYAKANT TUKARAM; SINGH GIRIJ PAL
权利人:LUPIN LTD
摘要:Provided herein is a process for the intermediates used for preparation of HIV Integrase Inhibitor such as Bictegravir, Dolutegravir, Cabotegravir or their pharmaceutically acceptable salts.

专利号:US-10745342-B2
优先权日:2018-07-05
标 题 :Synthesis method of 2,4,6-trifluorobenzylamine
发明人：YUAN QILIANG; QIAN JIE; LAI XIN; CHEN HAIFENG; CHEN YINHAO; WANG CHAO
权利人:ZHEJIANG ZHONGXIN FLUORIDE MAT CO LTD; SHAOXING ZHONGKE BAIYUN CHEMICAL TECH CO LTD
摘要:The disclosure provides a synthesis method of 2,4,6-trifluorobenzylamine, belonging to the technical field of chemical synthesis. The synthesis method is characterized by comprising the following steps: (1) allowing pentachlorobenzonitrile as a raw material to undergo fluoridation reaction with a fluoridation agent based on 2,4,6-trifluoro-3,5-dichlorobenzonitrile as a solvent to obtain 2,4,6-trifluoro-3,5-dichlorobenzonitrile; (2) hydrogenating the obtained 2,4,6-trifluoro-3,5-dichlorobenzonitrile with hydrogen in the presence of organic carboxylic acid, based, on palladium carbon as a catalyst to obtain 2,4,6-trifluoro-3,5-dichlorobenzylamine; and (3) hydrogenating the obtained 2,4,6-trifluoro-3,5-dichlorobenzylamine with hydrogen in a solvent in the presence of a catalyst to obtain 2,4,6-trifluorobenzylamine. The synthesis method has the advantages of low raw material cost, short reaction steps, high reaction yield, good product purity simple operation and the like, and is suitable for industrial production.

专利号:US-2021009606-A1
优先权日:2019-07-08
标题:Process for Preparation of Intermediates Used for the Synthesis of HIV Integrase Inhibitor

专利号:WO-2022182623-A1
优先权日:2021-02-23
标 题 :Polyfluorinated dicyclic compounds and methods of synthesis thereof