CAS: 1975-52-6; 2-Methyl-5-Nitrobenzoic Acid

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CAS号77324-87-9 2-甲基-5-硝基苯甲酸甲酯 | CAS号118-90-1 邻甲基苯甲酸 | CAS号99-51-4 4-硝基邻二甲苯 | CAS号939-83-3 2-甲基-5-硝基苯腈 | CAS号529-19-1 邻甲基苯腈 | CAS号95-47-6 邻二甲苯 | CAS号619-04-5 3,4-二甲基苯甲酸 | CAS号89-71-4 邻甲基苯甲酸甲酯 | CAS号7664-93-9 硫酸 | CAS号872791-71-4 (2-methyl-5-nit... | CAS号111437-10-6 3-(hydroxymethy... | CAS号1093070-15-5 (R)-2-甲基-N-(1-(... | CAS号90725-68-1 2-溴甲基-5-硝基苯甲酸甲酯 | CAS号22474-47-1 2-甲基-5-硝基苯甲醇 | CAS号788081-99-2 2-溴甲基-5-甲氧基苯甲酸甲酯 | CAS号578-22-3 5-羟基-2-甲基苯甲酸 | CAS号77324-87-9 2-甲基-5-硝基苯甲酸甲酯 | CAS号129229-78-3 5-nitro-2-(phen... | CAS号2840-04-2 5-氨基-2-甲基苯甲酸 | CAS号34265-55-9 BENZOIC ACID, 5...

对甲苯甲酸置于硫酸,硝酸,溶剂黄146体系中,化学反应生成2-甲基-5-硝基苯甲酸
参考文献:的发现ñ-(3-(吗啉代甲基)-苯基)-酰胺作为有效的和选择性cb 2激动剂
标题:的发现ñ-(3-(吗啉代甲基)-苯基)-酰胺作为有效的和选择性cb 2激动剂
摘要:最近,氨磺酰基苯甲酰胺被确定为一系列新的大麻素受体配体.取代磺酰胺官能团并逆转原始的羧酰胺键导致发现n-(3-(吗啉代甲基)-苯基)-酰胺作为有效的和选择性的cb 2激动剂.选择性cb 2激动剂31(k I = 2.7; Cb 1 / Cb 2 = 190)在术后疼痛的啮齿动物模型中显示出强大的活性.
Doi:10.1016/j.Bmcl.2009.07.057

专利信息

专利号:US-8188113-B2
优先权日:2006-09-14
标 题 :Dihydropyridopyrimidinyl, dihydronaphthyidinyl and related compounds useful as kinase inhibitors for the treatment of proliferative diseases
发明人：FLYNN DANIEL L; PETILLO PETER A; KAUFMAN MICHAEL D; PATT WILLIAM C
权利人:FLYNN DANIEL L; PETILLO PETER A; KAUFMAN MICHAEL D; PATT WILLIAM C; DECIPHERA PHARMACEUTICALS INC
摘要:The present invention relates to novel dihydropyridopyrimidinyl, dihydronaphthyridinyl, and related compounds which are kinase inhibitors and modulator useful for the treatment of various diseases. More particularly, the invention is concerned with such compounds, kinase/compound adducts, methods of treating diseases, and methods of synthesis of the compounds. Preferably, the compounds are useful for the modulation of kinase activity of Raf kinases and disease polymorphs thereof. Compounds of the present invention find utility in the treatment of mammalian cancers and especially human cancers including but not limited to malignant melanoma, colorectal cancer, ovarian cancer, papillary thyroid carcinoma, non small cell lung cancer, and mesothelioma. Compounds of the present invention also find utility in the treatment of rheumatoid arthritis and retinopathies including diabetic retinal neuropathy and macular degeneration.

专利号:US-5846993-A
优先权日:1992-12-22
标题:HIV protease inhibitors
发明人：DRESSMAN BRUCE A; FRITZ JAMES E; KALDOR STEPHEN W; KALISH VINCENT J; REICH SIEGFRIED HEINZ; TATLOCK JOHN H; RODRIGUEZ MICHAEL J
权利人:AGOURON PHARMA
摘要:HIV protease inhibitors, obtainable by chemical synthesis, inhibit or block the biological activity of the HIV protease enzyme, causing the replication of the HIV virus to terminate. These compounds, as well as pharmaceutical compositions that contain these compounds and optionally other anti-viral agents as active ingredients, are suitable for treating patients or hosts infected with the HIV virus, which is known to cause AIDS.

专利号:US-2012009151-A1
优先权日:2007-12-21
标题 :Triazines And Related Compounds Having Antiviral Activity, Compositions And Methods Thereof
发明人：HAN AMY QI; COBURN GLEN A; PROVONCHA KATHLEEN P; ROTSHTEYN YAKOV
权利人:HAN AMY QI; COBURN GLEN A; PROVONCHA KATHLEEN P; ROTSHTEYN YAKOV; PROGENICS PHARM INC
摘要:Disclosed herein are novel triazines and related compounds, the synthesis thereof, and compositions, including pharmaceutical compositions, comprising the novel triazines and related compounds. Such novel triazines and related compounds function to inhibit or block entry of viruses of the Flaviviridae family, including Hepatitis C virus (HCV), into cells that are susceptible to virus infection. These compounds are useful for the treatment, therapy and/or prophylaxis of viral diseases and infection, including HCV infection.

专利号:RU-2117659-C1
优先权日:1992-02-04
标题:Carbopenem derivatives, their pharmaceutically acceptable salts and hydrolyzed in vivo esters (variants), method of synthesis (variants), pharmaceutical composition showing antibacterial activity, derivatives of pyrrolidine-4-ylthiol and protected derivatives of pyrrolidine-4-ylthiol

专利号:US-6271235-B1
优先权日:1992-12-22
标题:HIV protease inhibitors
发明人：DRESSMAN BRUCE A; FRITZ JAMES E; KALDOR STEPHEN W; KALISH VINCENT J; REICH SIEGFRIED HEINZ; RODRIGUEZ MICHAEL J; SHEPHERD TIMOTHY A; TATLOCK JOHN H; JUNGHEIM LOUIS NICKOLAUS
权利人:AGOURON PHARMA
摘要:HIV protease inhibitors, obtainable by chemical synthesis, inhibit or block the biological activity of the HIV protease enzyme, causing the replication of the HIV virus to terminate. These compounds, as well as pharmaceutical compositions that contain these compounds and optionally other anti-viral agents as active ingredients, are suitable for treating patients or hosts infected with the HIV virus, which is known to cause AIDS.

专利号:WO-2014072985-A1
优先权日:2012-11-06
标题:Novel boronic acid derivatives as anti cancer agents
发明人：ADIBHATLA KALI SATYA BHUJANGA RAO; MUDDASANI PULLA REDDY; RAVI JANAKI RAMA RAO; KONDAVEETI SWAPNA; KOTA SATYANARAYANA; BATTULA SUNEEL KUMAR; NANNAPANENI VENKAIAH CHOWDARY
权利人:NATCO PHARMA LTD
摘要:The invention relates to synthesis and anticancer activity of novel boronic acid derivatives of formula 5 or pharmaceutical acceptable salts and esters thereof. Anti cancer activity of the compounds is evaluated by in vitro study on cancer cell lines like prostate cancer, lung cancer, head and neck cancer or breast cancer.