CAS: 213133-77-8; 2-(3,4-Dichlorobenzyl)-1H-Benzo[d]Imidazole

相似化合物

5468-66-6 154660-96-5 213133-88-1

2',3',4'-三氯苯乙酮置于ammonium Hydroxide,Copper(L) Iodide,L-脯氨酸,Sodium Hydroxide体系中,用 四氢呋喃,水,二甲基亚砜 用作溶剂,化学反应 10.0H,反应生成2-(3,4-二氯苄基)-1H-苯并咪唑
参考文献:Discovery Of Benzimidazole Derivatives As Modulators Of Mitochondrial Function: A Potential Treatment For Alzheimer'S Disease
标题:Discovery Of Benzimidazole Derivatives As Modulators Of Mitochondrial Function: A Potential Treatment For Alzheimer'S Disease
摘要:In This Study,We Designed A Library Of Compounds Based On The Structures Of Well-Known Ligands Of The 18 Kda Translocator Protein (Tspo),One Of The Putative Components Of The Mptp. We Performed Diverse Mitochondrial Functional Assays To Assess Their Ability To Restore Cells From A Beta-Induced Toxicity In Vitro And In Vivo. Among Tested Compounds,Compound 25 Effectively Improved Cognitive Function In Animal Models Of Ad. Given The Excellent In Vitro And In Vivo Activity And A Favorable Pharmacokinetic Profile Of Compound 25,We Believe That It Can Serve As A Promising Lead Compound For A Potential Treatment Option For Ad. (C) 2016 Elsevier Masson Sas. All Rights Reserved.
Doi:10.1016/j.Ejmech.2016.11.017