CAS: 29274-24-6; 5-Chloropyrazolo[1,5-A]Pyrimidine

相似化合物

57489-77-7 58347-49-2 189116-36-7

上下游产品

吡唑并[1,5-A]嘧啶-5(4H)-酮 Pyrazolo[1,5-A]Pyrimidin-5-Ol 29274-22-4
5-溴吡唑并[1,5-A]嘧啶 5-Bromopyrazolo[1,5-A]Pyrimidine 1159981-95-9

5-溴吡唑并[1,5-A]嘧啶置于三氯氧磷体系中,化学反应生成5-氯吡唑并[1,5-A]嘧啶
参考文献:Combination Of Kinase Inhibitors And Uses Thereof
标题:Combination Of Kinase Inhibitors And Uses Thereof
摘要:本发明提供了一种治疗与pi3-激酶a和/或受体酪氨酸激酶(rtk)有关的疾病状况的方法.另一方面,该发明提供了一种治疗与pi3-激酶α和/或受体酪氨酸激酶(rtk)有关的疾病状况的方法.另一方面,提出了一种抑制细胞中akt(s473)磷酸化的方法.

专利信息

专利号:US-9676783-B2
优先权日:2008-10-22
标 题:Method of treatment using substituted pyrazolo[1,5-A] pyrimidine compounds
发明人：HAAS JULIA; ANDREWS STEVEN W; JIANG YUTONG; ZHANG GAN
权利人:ARRAY BIOPHARMA INC
摘要:Compounds useful in the synthesis of compounds for treating pain, cancer, inflammation, neurodegenerative disease or Typanosoma cruzi infection in a mammal.

专利号:WO-2024108957-A1
优先权日:2022-11-23
标题 :5-cyanopyrazolo[1,5-a]pyrimidine compound and synthesis method therefor
发明人：MA SHITANG; Qu Hengtong; XU QILIN; SUN CHAOYUE; CHEN NAIDONG
权利人:UNIV WEST ANHUI
摘要:Disclosed is a 5-cyanopyrazolo[1,5-a]pyrimidine compound represented by formula III, wherein R1 is hydrogen, chlorine, bromine, a cyano, a carboxyethoxy, a methyl, an isopropyl, a tert-butyl, a cyclopropyl, an isopropoxy, a phenyl, a 4-fluorophenyl, a 4-chlorophenyl, a 4-methylphenyl, a 4-methoxyphenyl, or a 3-methoxyphenyl, and R2 is a phenyl, a 4-fluorophenyl, a 4-chlorophenyl, a 4-bromophenyl, a 4-methylphenyl, a 4-dimethylaminophenyl, or a furyl. Further disclosed is a method for synthesizing a 5-cyanopyrazolo[1,5-a]pyrimidine compound. The method comprises: mixing a 3-aminopyrazole compound, a cinnamaldehyde derivative, a trimethylsilyl cyanide, a catalyst, a ligand, and a reaction solvent, and reacting same in the presence of oxygen, so as to obtain a 5-cyanopyrazolo[1,5-a]pyrimidine compound.

专利号:DK-2725028-T3
优先权日:2008-10-22
标题:Substituted pyrazolo [1,5-a] pyrimidine compounds as intermediates in the synthesis of kinase inhibitors TRK

专利号:EP-2725028-A1
优先权日:2008-10-22
标题 :Substituted pyrazolo[1,5-]pyrimidine compounds as intermediates in the synthesis of TRK kinase inhibitors

专利号:EP-2725028-B1
优先权日:2008-10-22
标题 :Substituted pyrazolo[1,5-]pyrimidine compounds as intermediates in the synthesis of TRK kinase inhibitors

专利号:HU-E030413-T2
优先权日:2008-10-22
标 题:Substituted pyrazolo[1,5-]pyrimidine compounds as intermediates in the synthesis of TRK kinase inhibitors