CAS: 34841-06-0; 3-Bromo-4-Methoxybenzaldehyde

该化合物是一种有机化合物,其特点是芳香结构,其特点是溴原子和与苯甲二苯基酸酯相关的甲氧基组,其存在引入了卤素,可影响该化合物的再活性和极度,而甲基氧组则助长其电子食用特性,影响其总体电子分布.该化合物一般会以浅黄色至浅褐色固体或液体的形式出现,取决于其纯度和具体条件.在乙醇和二氯甲烷等有机溶剂中可溶性,但由于其缺水芳芳香结构,水溶性有限. 3-Bromo-4-methhoyoxybenzalthydayde经常用于有机合成,特别是用于制作各种药品和农用化学品,因为其功能组可参与进一步的化学反应,例如核循环替代或凝聚反应.在处理该化合物时,应当采取安全防范措施,因为如果在其中构成健康风险或危险.

结构式图片

欧盟法规

ECHA物质C&L通报REACH预注册

上下游产品

CAS号123-11-5 4-甲氧基苯甲醛; 对甲氧基苯... | CAS号38493-59-3 3-溴-4-甲氧基苄醇 | CAS号105-13-5 对甲氧基苄醇 | CAS号35103-34-5 ACETAMIDE, N-[(... | CAS号2973-78-6 3-溴-4-羟基苯甲醛 | CAS号77-78-1 硫酸二甲酯 | CAS号67-56-1 甲醇 | CAS号6399-81-1 三苯基膦氢溴酸盐 | CAS号223418-72-2 1-BROMO-5-(1,3-... | CAS号35450-37-4 3-溴-4-甲氧基苯甲酸甲酯 | CAS号38493-59-3 3-溴-4-甲氧基苄醇 | CAS号84923-70-6 5-甲酰基-2-甲氧基苯甲酸 | CAS号772-59-8 3-溴-4-甲氧基苄腈 | CAS号774-81-2 3-溴-4-甲氧基苯乙酸 | CAS号127972-02-5 5-醛基-2-甲氧基苯硼酸 | CAS号117572-79-9 3-溴-4-甲氧基苯腈 | CAS号34039-30-0 2-Bromo-1-metho... | CAS号2973-78-6 3-溴-4-羟基苯甲醛 | CAS号17332-12-6 3-溴-4-甲氧基苯酚

合成工艺路线路线简述

    4-甲氧基苯甲醛置于bismuth(III) Chloride,N-溴代丁二酰亚胺(Nbs),D(+)-10-樟脑磺酸体系中,用 乙腈 用作溶剂,以95 %的收率获得3-溴-4-甲氧基苯甲醛
    参考文献:D-樟脑磺酸-Bicl3 催化 N-卤代琥珀酰亚胺 (Nxs) 卤化芳香族化合物
    标题:D-樟脑磺酸-Bicl3 催化 N-卤代琥珀酰亚胺 (Nxs) 卤化芳香族化合物
    摘要:空气条件下,0.5~10 Mol% D-樟脑磺酸-Bicl3 与n-溴代琥珀酰亚胺 (Nbs)置于mecn 中进行芳香溴化反应,并扩展到n-氯代琥珀酰亚胺 (Ncs) 和n-溴代琥珀酰亚胺 (Ncs) 的反应.碘代琥珀酰亚胺(nis).还尝试了一些药物和天然产物的卤化.在不除去溶剂的情况下,实现了一锅溴化/suzuki-Miyaura交叉偶联和溴化/sonogashira偶联反应.
    Doi:10.1039/d4Ob00837E

    海关参考信息

    专利信息


    专利号:US-2021284618-A1
    优先权日:2016-08-12
    标 题 :Furanochalcones as inhibitors of cyp1a1, cyp1a2 and cyp1b1 for cancer chemoprevention
    发明人:BHARATE SANDIP BIBISHAN; SHARMA RAJNI; JOSHI PRASHANT; VISHWAKARMA RAM; CHAUDHURI BHABATOSH
    权利人:COUNCIL SCIENT IND RES; DE MONTFORT UNIV
    摘要:The present invention relates to the furanochalcone class of compounds of general formula A. The present invention particularly relates to the synthesis of furanochalcones and their CYP1A1, CYP1A2 and CYP1B1 inhibitory activity. In addition, the invention relates to the prevention or treatment of cancer caused by polyaromatic hydrocarbons (PAHs), 4-nitroquinoline-1-oxide, and N-nitroso-N-methylurea, heterocyclic amines, estrogen and 17β-estradiol, resulting from the inhibition of CYP1A1, CYP1A2 and CYP1B1 enzymes.

    专利号:US-4582903-A
    优先权日:1984-08-17
    标 题 :Synthesis of unsaturated hydantoins with an inexpensive catalyst
    发明人:MIRVISS STANLEY B
    权利人:STAUFFER CHEMICAL CO
    摘要:Alkylidene or arylidene substituted hydantoins are produced by condensation of an aromatic or aliphatic aldehyde with hydantoin in the presence of at least one basic salt of an inorganic acid. The desired products are obtained in high yields.

    专利号:WO-0053313-A2
    优先权日:1999-03-09
    标 题:Lanthanide catalysts for synthesis of compounds and combinatorial libraries

    专利号:WO-0056709-A1
    优先权日:1999-03-24
    标 题:Indolinone compounds as kinase inhibitors
    发明人:TANG PENG CHO; SUN LI; MCMAHON GERALD; MILLER TODD ANTHONY; SHIRAZIAN SHAHRZAD; WEI CHUNG CHEN; HARRIS G DAVIS; XIAOYUAN LI; LIANG CONGXIN
    权利人:SUGEN INC; TANG PENG CHO; SUN LI; MCMAHON GERALD; MILLER TODD ANTHONY; SHIRAZIAN SHAHRZAD; WEI CHUNG CHEN; HARRIS G DAVIS; XIAOYUAN LI; LIANG CONGXIN
    摘要:The invention relates to certain indolinone compounds, their method of synthesis, and a combinatorial library consisting of the indolinone compounds of the invention. The invention also relates to methods of modulating the function of protein kinases using indolinone compounds of the invention and methods of treating diseases by modulating the function of protein kinases and related signal transduction pathways.

    专利号:US-2013150376-A1
    优先权日:2010-04-09
    标 题:Novel Sultam Compounds
    发明人:BRODNEY MICHAEL AARON; EFREMOV IVAN VIKTOROVICH; HELAL CHRISTOPHER JOHN; O'NEILL BRIAN THOMAS
    权利人:BRODNEY MICHAEL AARON; EFREMOV IVAN VIKTOROVICH; HELAL CHRISTOPHER JOHN; O'NEILL BRIAN THOMAS; PFIZER
    摘要:Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula I (I) as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.

    专利号:US-9879022-B2
    优先权日:2014-04-04
    标题:Bicyclic-fused heteroaryl or aryl compounds
    发明人:TRZUPEK JOHN DAVID; LEE KATHERINE LIN; BUNNAGE MARK EDWARD; HAN SEUNGIL; HEPWORTH DAVID; LOVERING FRANK ELDRIDGE; MATHIAS JOHN PAUL; PAPAIOANNOU NIKOLAOS; PIERCE BETSY SUSAN; STROHBACH JOSEPH WALTER; WRIGHT STEPHEN WAYNE; ZAPF CHRISTOPH WOLFGANG; GAVRIN LORI KRIM; LEE ARTHUR; ANDERSON DAVID RANDOLPH; CURRAN KEVIN JOSEPH; DEHNHARDT CHRISTOPH MARTIN; SAIAH EDDINE; GOLDBERG JOEL ADAM; WANG XIAOLUN; HUANG HORNG-CHIH; VARGAS RICHARD; LOWE MICHAEL DENNIS; PATNY AKSHAY
    权利人:PFIZER
    摘要:Compounds, tautomers and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula Ia, n nas defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.
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    主要参考文献

    参考标题:Ring Strain And Total Syntheses Of Modified Macrocycles Of The Isoplagiochin Type
    作者:Andreas Speicher,Timo Backes,Kerstin Hesidens,Jürgen Kolz
    摘要:Macrocycles Of The Bisbibenzyl-Type Are Natural Products That Are Found Exclusively In Bryophytes (Liverworts). The Molecular Framework Of The Subtype "Isoplagiochin" Is Of Substantial Structural Interest Because Of The Chirality Of The Entire Molecule, Which Arises From Two Biaryl Axes In Combination With Two Helical Two-Carbon Units In A Cyclic Arrangement. From A Structural As Well As A Synthetic Point Of View We Report On The Total Synthesis Of Compounds Which Possess More Rigid Two-Carbon Biaryl Bridges Like Stilbene (E Or Z) Or Even Tolane Moieties Which Were Introduced Starting With A Sonogashira Protocol. The Mcmurry Method Proved To Be A Powerful Tool For The Cyclization To These Considerably Ring-Strained Macrocycles.

    合成参考文献


    参考文献:10.1107/s1600536811016904
    摘要:Jasinski JP, Golen JA, Chidan Kumar CS, Narayana B, Yathirajan HS. (1E,2E)-1,2-Bis(3-bromo-4-methoxybenzylidene)hydrazine. Acta Crystallogr E Struct Rep Online. 2011 May 11;67(6):o1379. doi: 10.1107/s1600536811016904.
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